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- W2118948041 abstract "2-Phenyl-4-quinolone acetic acids and their esters were synthesized and evaluated for interaction with tubulin and for cytotoxicity against a panel of human tumor cell lines. 2-Phenyl- and 2-(2′-fluorophenyl)-4-quinolone-8-acetic acids (11 and 12) displayed potent cytotoxicity with ED50 values at nanomolar concentrations, but had minimal activity against tubulin polymerization. 2-(2′-Fluorophenyl)-4-quinolone-6-acetic acid (3) and 2-(2′-fluorophenyl)-4-quinolone-8-acetic acid methyl ester (10) moderately inhibited tubulin polymerization." @default.
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- W2118948041 date "2003-09-01" @default.
- W2118948041 modified "2023-09-29" @default.
- W2118948041 title "Antitumor agents. Part 226: synthesis and cytotoxicity of 2-Phenyl-4-quinolone acetic acids and their esters" @default.
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- W2118948041 doi "https://doi.org/10.1016/s0960-894x(03)00624-3" @default.
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