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• W2118956457 abstract "Nearly 1 of every 1000 people in the United States is on dialysis. More than 200,000 people were receiving either hemodialysis or peritoneal dialysis in 1997 at an annual estimated cost of $13.1 billion per year.76 More than 60,000 people develop dialysis-dependent end-stage renal disease (ESRD), and this number is expected to increase 6% to 9% annually.76 Seventy-five percent of patients with ESRD have gastrointestinal complaints (Table 1).1 Although some of these complaints may be specifically related to the techniques and procedures of the dialysis method itself, the physiologic state of chronic uremia is likely to contribute to the development of the majority of symptoms. The uremic condition is not eliminated when a patient is placed on dialysis. Only 10% of normal renal filtration function is restored when using either peritoneal or hemofiltration methods.59 Many substances are retained in the dialysis-dependent patient. The presence of these uremic retention products has substantial effects on cell and tissue function in many organ systems, including the gastrointestinal tract. The high prevalence of gastrointestinal symptoms in 1 million patients on long-term dialysis worldwide63 makes a clear understanding of the effects of uremia and ESRD on the gastrointestinal tract appropriate for the newly trained and seasoned gastroenterologist alike. This article begins with a brief review of the systemic effects of uremic toxins followed by a review of the effects of the uremic state on the esophagus, stomach, duodenum, and pancreas." @default.
• W2118956457 created "2016-06-24" @default.
• W2118956457 creator A5058560824 @default.
• W2118956457 date "1998-12-01" @default.
• W2118956457 modified "2023-09-27" @default.
• W2118956457 title "GASTROINTESTINAL COMPLICATIONS OF RENAL FAILURE" @default.
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• W2118956457 doi "https://doi.org/10.1016/s0889-8553(05)70036-4" @default.
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