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- W2118958365 abstract "Abstract Background: Nitric oxide (NO) plays a relevant role in various events during atherogenesis. In vitro data suggest that NO may modulate homocysteine (Hcy) concentrations. The aim of this study was to investigate the role of endothelial nitric oxide synthase (eNOS) −786T>C, 894G>T, and 4a4b polymorphisms in influencing Hcy concentrations. Methods: Blood samples were obtained from 1287 unrelated persons. Plasma Hcy was measured by fluorescence polarization immunoassay, folate and vitamin B12 by RIA, vitamin B6 by HPLC, and eNOS and methylenetetrahydrofolate reductase (MTHFR) gene polymorphisms by PCR with restriction fragment length polymorphism analysis. Results: MTHFR 677C>T polymorphism significantly influenced Hcy concentrations after adjustment for all confounding variables (P <0.0001 for trend). Univariate analysis showed that the eNOS −786T>C polymorphism, but not 894G>T and 4a4b, was significantly associated with the risk of having Hcy in the third tertile [>13.4 μmol/L; odds ratio (OR) = 1.2; 95% confidence interval (CI), 1.02–1.5; P = 0.03]. After adjustment for all variables known to influence Hcy, the −786T>C polymorphism still influenced Hcy concentrations (OR = 1.9; 95% CI, 1.1–3.2; P = 0.01). By analyzing the influence of eNOS polymorphisms on plasma Hcy concentrations according to vitamin concentrations (folate, vitamin B6, and vitamin B12), age, and smoking habits, we found a significant association between the eNOS −786T>C polymorphism and Hcy in nonsmokers, in persons with normal vitamin status, and in persons <60 years. Conclusion: The eNOS −786T>C polymorphism, but not 894G>T and 4a4b, influences plasma Hcy concentrations mildly but significantly and independently." @default.
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- W2118958365 date "2005-07-01" @default.
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- W2118958365 title "Endothelial Nitric Oxide Synthase −786T>C, but Not 894G>T and 4a4b, Polymorphism Influences Plasma Homocysteine Concentrations in Persons with Normal Vitamin Status" @default.
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- W2118958365 doi "https://doi.org/10.1373/clinchem.2005.048850" @default.
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