Matches in SemOpenAlex for { <https://semopenalex.org/work/W2118960089> ?p ?o ?g. }
- W2118960089 endingPage "139" @default.
- W2118960089 startingPage "131" @default.
- W2118960089 abstract "To address the underlying mechanisms by which curcumin facilitates M2 phenotype polarization of macrophages and its roles in the protective effects during experimental autoimmune myocarditis (EAM).The expression of classic M2 markers, including macrophage mannose receptor (MMR), arginase-1 (Arg-1) and peroxisome proliferator-activated receptor-γ (PPAR-γ) was upregulated in curcumin-treated Raw264.7 macrophages. Curcumin increased interleukin-4 (IL-4) and interleukin-13 (IL-13) mRNA expression and protein secretion. Curcumin notably increased STAT6 phosphorylation. Leflunomide, a STAT6 inhibitor, and IL-4 and/or IL-13 neutralizing antibodies antagonized the induction of MMR, Arg-1 and PPAR-γ by curcumin in Raw264.7 cells. In vivo, 6-week old male Lewis rats were used to induce EAM and orally administrated with curcumin or corn oil for 3weeks after myosin injection. Cardiac functional parameters, including left ventricular fractional shortening (LVFS), ejection fraction (EF), left ventricular end-systolic diameter (LVEDs) and heart rate (HR) were significantly improved by curcumin treatment. Curcumin also reduced the inflammatory cell infiltration and myocardial mRNA levels of interleukin-1β (IL-1β) and inducible nitric oxide synthase (iNOS). Meanwhile, the myocardial mRNA levels of MMR and Arg-1 were markedly up-regulated by curcumin. Immunofluorescence assay showed that the number of CD68(+) MMR(+) and CD68(+) Arg-1(+) double positive macrophages in curcumin-treated myocardial tissue was significantly higher than untreated control. The number of CD68(+) iNOS(+) double positive macrophages was increased obviously in EAM group, but decreased markedly by curcumin treatment.Taken together, these results show that curcumin induces macrophage M2 polarization by secretion of IL-4 and/or IL-13. Curcumin ameliorates EAM by reducing infiltration inflammatory macrophages and by polarizing M0 and M1 macrophages to M2 phenotype." @default.
- W2118960089 created "2016-06-24" @default.
- W2118960089 creator A5000815865 @default.
- W2118960089 creator A5012884517 @default.
- W2118960089 creator A5021293751 @default.
- W2118960089 creator A5021583132 @default.
- W2118960089 creator A5021681216 @default.
- W2118960089 creator A5023115890 @default.
- W2118960089 creator A5026482652 @default.
- W2118960089 creator A5033709305 @default.
- W2118960089 creator A5045545412 @default.
- W2118960089 creator A5066213432 @default.
- W2118960089 creator A5071867794 @default.
- W2118960089 creator A5076009928 @default.
- W2118960089 creator A5080293953 @default.
- W2118960089 creator A5089507199 @default.
- W2118960089 date "2015-08-01" @default.
- W2118960089 modified "2023-10-17" @default.
- W2118960089 title "Curcumin induces M2 macrophage polarization by secretion IL-4 and/or IL-13" @default.
- W2118960089 cites W1509258310 @default.
- W2118960089 cites W1975021551 @default.
- W2118960089 cites W1978356562 @default.
- W2118960089 cites W1991160853 @default.
- W2118960089 cites W1992465162 @default.
- W2118960089 cites W1996701771 @default.
- W2118960089 cites W1999367044 @default.
- W2118960089 cites W2004542916 @default.
- W2118960089 cites W2009170266 @default.
- W2118960089 cites W2019180307 @default.
- W2118960089 cites W2022618390 @default.
- W2118960089 cites W2027768860 @default.
- W2118960089 cites W2035817205 @default.
- W2118960089 cites W2039183048 @default.
- W2118960089 cites W2041840384 @default.
- W2118960089 cites W2045350680 @default.
- W2118960089 cites W2049513468 @default.
- W2118960089 cites W2054472394 @default.
- W2118960089 cites W2056694311 @default.
- W2118960089 cites W2065210647 @default.
- W2118960089 cites W2067754406 @default.
- W2118960089 cites W2070855360 @default.
- W2118960089 cites W2078668858 @default.
- W2118960089 cites W2083198686 @default.
- W2118960089 cites W2084790890 @default.
- W2118960089 cites W2085193829 @default.
- W2118960089 cites W2092584311 @default.
- W2118960089 cites W2093705034 @default.
- W2118960089 cites W2096626379 @default.
- W2118960089 cites W2106427090 @default.
- W2118960089 cites W2121438383 @default.
- W2118960089 cites W2126326715 @default.
- W2118960089 cites W2130814871 @default.
- W2118960089 cites W2149869796 @default.
- W2118960089 cites W2153930350 @default.
- W2118960089 doi "https://doi.org/10.1016/j.yjmcc.2015.04.025" @default.
- W2118960089 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/25944087" @default.
- W2118960089 hasPublicationYear "2015" @default.
- W2118960089 type Work @default.
- W2118960089 sameAs 2118960089 @default.
- W2118960089 citedByCount "135" @default.
- W2118960089 countsByYear W21189600892015 @default.
- W2118960089 countsByYear W21189600892016 @default.
- W2118960089 countsByYear W21189600892017 @default.
- W2118960089 countsByYear W21189600892018 @default.
- W2118960089 countsByYear W21189600892019 @default.
- W2118960089 countsByYear W21189600892020 @default.
- W2118960089 countsByYear W21189600892021 @default.
- W2118960089 countsByYear W21189600892022 @default.
- W2118960089 countsByYear W21189600892023 @default.
- W2118960089 crossrefType "journal-article" @default.
- W2118960089 hasAuthorship W2118960089A5000815865 @default.
- W2118960089 hasAuthorship W2118960089A5012884517 @default.
- W2118960089 hasAuthorship W2118960089A5021293751 @default.
- W2118960089 hasAuthorship W2118960089A5021583132 @default.
- W2118960089 hasAuthorship W2118960089A5021681216 @default.
- W2118960089 hasAuthorship W2118960089A5023115890 @default.
- W2118960089 hasAuthorship W2118960089A5026482652 @default.
- W2118960089 hasAuthorship W2118960089A5033709305 @default.
- W2118960089 hasAuthorship W2118960089A5045545412 @default.
- W2118960089 hasAuthorship W2118960089A5066213432 @default.
- W2118960089 hasAuthorship W2118960089A5071867794 @default.
- W2118960089 hasAuthorship W2118960089A5076009928 @default.
- W2118960089 hasAuthorship W2118960089A5080293953 @default.
- W2118960089 hasAuthorship W2118960089A5089507199 @default.
- W2118960089 hasConcept C126322002 @default.
- W2118960089 hasConcept C134018914 @default.
- W2118960089 hasConcept C185592680 @default.
- W2118960089 hasConcept C202751555 @default.
- W2118960089 hasConcept C204232928 @default.
- W2118960089 hasConcept C2776205754 @default.
- W2118960089 hasConcept C2776460901 @default.
- W2118960089 hasConcept C2776682551 @default.
- W2118960089 hasConcept C2777622882 @default.
- W2118960089 hasConcept C2778250585 @default.
- W2118960089 hasConcept C2778690821 @default.
- W2118960089 hasConcept C2779244956 @default.
- W2118960089 hasConcept C2910375186 @default.
- W2118960089 hasConcept C519581460 @default.