FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2118962346> ?p ?o ?g. }

• W2118962346 endingPage "22116" @default.
• W2118962346 startingPage "22102" @default.
• W2118962346 abstract "The septin gene belongs to a highly conserved family of polymerizing GTP-binding cytoskeletal proteins. SEPTs perform cytoskeletal remodeling, cell polarity, mitosis, and vesicle trafficking by interacting with various cytoskeletons. Our previous studies have indicated that SEPTIN12+/+/+/− chimeras with a SEPTIN12 mutant allele were infertile. Spermatozoa from the vas deferens of chimeric mice indicated an abnormal sperm morphology, decreased sperm count, and immotile sperm. Mutations and genetic variants of SEPTIN12 in infertility cases also caused oligozoospermia and teratozoospermia. We suggest that a loss of SEPT12 affects the biological function of microtublin functions and causes spermiogenesis defects. In the cell model, SEPT12 interacts with α- and β-tubulins by co-immunoprecipitation (co-IP). To determine the precise localization and interactions between SEPT12 and α- and β-tubulins in vivo, we created SEPTIN12-transgene mice. We demonstrate how SEPT12 interacts and co-localizes with α- and β-tubulins during spermiogenesis in these mice. By using shRNA, the loss of SEPT12 transcripts disrupts α- and β-tubulin organization. In addition, losing or decreasing SEPT12 disturbs the morphogenesis of sperm heads and the elongation of sperm tails, the steps of which are coordinated and constructed by α- and β-tubulins, in SEPTIN12+/+/+/− chimeras. In this study, we discovered that the SEPTIN12-microtubule complexes are critical for sperm formation during spermiogenesis." @default.
• W2118962346 created "2016-06-24" @default.
• W2118962346 creator A5001497797 @default.
• W2118962346 creator A5003355054 @default.
• W2118962346 creator A5007561160 @default.
• W2118962346 creator A5027663338 @default.
• W2118962346 creator A5045248168 @default.
• W2118962346 creator A5050466653 @default.
• W2118962346 creator A5052912780 @default.
• W2118962346 creator A5084321349 @default.
• W2118962346 creator A5087541007 @default.
• W2118962346 date "2013-11-07" @default.
• W2118962346 modified "2023-10-04" @default.
• W2118962346 title "SEPT12-Microtubule Complexes Are Required for Sperm Head and Tail Formation" @default.
• W2118962346 cites W1937573969 @default.
• W2118962346 cites W1973044543 @default.
• W2118962346 cites W1974920191 @default.
• W2118962346 cites W1977974050 @default.
• W2118962346 cites W1987793820 @default.
• W2118962346 cites W1991660576 @default.
• W2118962346 cites W1993728115 @default.
• W2118962346 cites W1994842913 @default.
• W2118962346 cites W2018159649 @default.
• W2118962346 cites W2019889495 @default.
• W2118962346 cites W2026364178 @default.
• W2118962346 cites W2033026766 @default.
• W2118962346 cites W2035198448 @default.
• W2118962346 cites W2037386843 @default.
• W2118962346 cites W2037399479 @default.
• W2118962346 cites W2039186803 @default.
• W2118962346 cites W2041521407 @default.
• W2118962346 cites W2042659536 @default.
• W2118962346 cites W2045819499 @default.
• W2118962346 cites W2055376777 @default.
• W2118962346 cites W2057183375 @default.
• W2118962346 cites W2057721983 @default.
• W2118962346 cites W2066199533 @default.
• W2118962346 cites W2069345749 @default.
• W2118962346 cites W2069871388 @default.
• W2118962346 cites W2070368200 @default.
• W2118962346 cites W2070520948 @default.
• W2118962346 cites W2083555181 @default.
• W2118962346 cites W2088190945 @default.
• W2118962346 cites W2089816365 @default.
• W2118962346 cites W2091168806 @default.
• W2118962346 cites W2093325895 @default.
• W2118962346 cites W2096879243 @default.
• W2118962346 cites W2099757502 @default.
• W2118962346 cites W2103316746 @default.
• W2118962346 cites W2112597950 @default.
• W2118962346 cites W2112995359 @default.
• W2118962346 cites W2120856608 @default.
• W2118962346 cites W2124956392 @default.
• W2118962346 cites W2125186370 @default.
• W2118962346 cites W2129759722 @default.
• W2118962346 cites W2140240207 @default.
• W2118962346 cites W2141169141 @default.
• W2118962346 cites W2159394238 @default.
• W2118962346 cites W2159778526 @default.
• W2118962346 doi "https://doi.org/10.3390/ijms141122102" @default.
• W2118962346 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3856054" @default.
• W2118962346 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/24213608" @default.
• W2118962346 hasPublicationYear "2013" @default.
• W2118962346 type Work @default.
• W2118962346 sameAs 2118962346 @default.
• W2118962346 citedByCount "26" @default.
• W2118962346 countsByYear W21189623462014 @default.
• W2118962346 countsByYear W21189623462015 @default.
• W2118962346 countsByYear W21189623462016 @default.
• W2118962346 countsByYear W21189623462017 @default.
• W2118962346 countsByYear W21189623462018 @default.
• W2118962346 countsByYear W21189623462019 @default.
• W2118962346 countsByYear W21189623462020 @default.
• W2118962346 countsByYear W21189623462021 @default.
• W2118962346 countsByYear W21189623462022 @default.
• W2118962346 countsByYear W21189623462023 @default.
• W2118962346 crossrefType "journal-article" @default.
• W2118962346 hasAuthorship W2118962346A5001497797 @default.
• W2118962346 hasAuthorship W2118962346A5003355054 @default.
• W2118962346 hasAuthorship W2118962346A5007561160 @default.
• W2118962346 hasAuthorship W2118962346A5027663338 @default.
• W2118962346 hasAuthorship W2118962346A5045248168 @default.
• W2118962346 hasAuthorship W2118962346A5050466653 @default.
• W2118962346 hasAuthorship W2118962346A5052912780 @default.
• W2118962346 hasAuthorship W2118962346A5084321349 @default.
• W2118962346 hasAuthorship W2118962346A5087541007 @default.
• W2118962346 hasBestOaLocation W21189623461 @default.
• W2118962346 hasConcept C104317684 @default.
• W2118962346 hasConcept C142669718 @default.
• W2118962346 hasConcept C1491633281 @default.
• W2118962346 hasConcept C153911025 @default.
• W2118962346 hasConcept C20418707 @default.
• W2118962346 hasConcept C2776803348 @default.
• W2118962346 hasConcept C2778619154 @default.
• W2118962346 hasConcept C2781087480 @default.
• W2118962346 hasConcept C54355233 @default.
• W2118962346 hasConcept C71829478 @default.
• W2118962346 hasConcept C84425145 @default.

• next