FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2118962787> ?p ?o ?g. }

• W2118962787 endingPage "117" @default.
• W2118962787 startingPage "106" @default.
• W2118962787 abstract "The CD40 ligand (CD40L)-CD40 dyad can ignite proinflammatory and procoagulatory activities of the vascular endothelium in the pathogenesis and progression of atherosclerosis. Besides being expressed on the activated CD4(+) T cell surface (mCD40L), the majority of circulating CD40L reservoir (sCD40L) in plasma is released from stimulated platelets. It remains debatable which form of CD40L triggers endothelial inflammation. Here, we demonstrate that the agonistic antibody of CD40 (G28.5), which mimics the action of sCD40L, induces rapid endocytosis of CD40 independent of TRAF2/3/6 binding while CD40L expressed on the surface of HEK293A cells captures CD40 at the cell conjunction. Forced internalization of CD40 by constitutively active mutant of Rab5 preemptively activates NF-kappaB pathway, suggesting that CD40 was able to form an intracellular signal complex in the early endosomes. Internalized CD40 exhibits different patterns of TRAF2/3/6 recruitment and Akt phosphorylation from the membrane anchored CD40 complex. Finally, mCD40L but not sCD40L induces the upregulation of proinflammatory cytokines and cell adhesion factors in the primary human vascular endothelial cells in vitro, although both forms of CD40L activate NF-kappaB pathway. These results therefore may help understand the molecular mechanism of CD40L signaling that contributes to the pathophysiology of atherosclerosis." @default.
• W2118962787 created "2016-06-24" @default.
• W2118962787 creator A5010090486 @default.
• W2118962787 creator A5024419531 @default.
• W2118962787 creator A5039588574 @default.
• W2118962787 creator A5057326412 @default.
• W2118962787 creator A5067835602 @default.
• W2118962787 creator A5073647724 @default.
• W2118962787 creator A5085824200 @default.
• W2118962787 date "2006-06-01" @default.
• W2118962787 modified "2023-09-23" @default.
• W2118962787 title "Internalization of CD40 regulates its signal transduction in vascular endothelial cells" @default.
• W2118962787 cites W1561516029 @default.
• W2118962787 cites W1595083713 @default.
• W2118962787 cites W1649342667 @default.
• W2118962787 cites W1918912342 @default.
• W2118962787 cites W1980087271 @default.
• W2118962787 cites W1983989958 @default.
• W2118962787 cites W1989294105 @default.
• W2118962787 cites W2003074932 @default.
• W2118962787 cites W2007797957 @default.
• W2118962787 cites W2014263971 @default.
• W2118962787 cites W2019472123 @default.
• W2118962787 cites W2022376210 @default.
• W2118962787 cites W2022405886 @default.
• W2118962787 cites W2022897423 @default.
• W2118962787 cites W2029013083 @default.
• W2118962787 cites W2032504743 @default.
• W2118962787 cites W2033478138 @default.
• W2118962787 cites W2034485512 @default.
• W2118962787 cites W2037181648 @default.
• W2118962787 cites W2047876133 @default.
• W2118962787 cites W2049652225 @default.
• W2118962787 cites W2052244692 @default.
• W2118962787 cites W2053215305 @default.
• W2118962787 cites W2057159816 @default.
• W2118962787 cites W2063641436 @default.
• W2118962787 cites W2078262488 @default.
• W2118962787 cites W2080051209 @default.
• W2118962787 cites W2081440498 @default.
• W2118962787 cites W2086583876 @default.
• W2118962787 cites W2091050865 @default.
• W2118962787 cites W2108106334 @default.
• W2118962787 cites W2109044040 @default.
• W2118962787 cites W2110640974 @default.
• W2118962787 cites W2112547972 @default.
• W2118962787 cites W2115271408 @default.
• W2118962787 cites W2116815941 @default.
• W2118962787 cites W2118762274 @default.
• W2118962787 cites W2121776150 @default.
• W2118962787 cites W2125251546 @default.
• W2118962787 cites W2129212432 @default.
• W2118962787 cites W2141681336 @default.
• W2118962787 cites W2142039559 @default.
• W2118962787 cites W2148597937 @default.
• W2118962787 cites W2151635468 @default.
• W2118962787 cites W2172658766 @default.
• W2118962787 cites W276577763 @default.
• W2118962787 doi "https://doi.org/10.1016/j.bbrc.2006.04.034" @default.
• W2118962787 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/16677604" @default.
• W2118962787 hasPublicationYear "2006" @default.
• W2118962787 type Work @default.
• W2118962787 sameAs 2118962787 @default.
• W2118962787 citedByCount "64" @default.
• W2118962787 countsByYear W21189627872012 @default.
• W2118962787 countsByYear W21189627872013 @default.
• W2118962787 countsByYear W21189627872014 @default.
• W2118962787 countsByYear W21189627872015 @default.
• W2118962787 countsByYear W21189627872016 @default.
• W2118962787 countsByYear W21189627872017 @default.
• W2118962787 countsByYear W21189627872018 @default.
• W2118962787 countsByYear W21189627872019 @default.
• W2118962787 countsByYear W21189627872020 @default.
• W2118962787 countsByYear W21189627872021 @default.
• W2118962787 crossrefType "journal-article" @default.
• W2118962787 hasAuthorship W2118962787A5010090486 @default.
• W2118962787 hasAuthorship W2118962787A5024419531 @default.
• W2118962787 hasAuthorship W2118962787A5039588574 @default.
• W2118962787 hasAuthorship W2118962787A5057326412 @default.
• W2118962787 hasAuthorship W2118962787A5067835602 @default.
• W2118962787 hasAuthorship W2118962787A5073647724 @default.
• W2118962787 hasAuthorship W2118962787A5085824200 @default.
• W2118962787 hasConcept C11960822 @default.
• W2118962787 hasConcept C123012128 @default.
• W2118962787 hasConcept C134018914 @default.
• W2118962787 hasConcept C139770010 @default.
• W2118962787 hasConcept C1491633281 @default.
• W2118962787 hasConcept C154317977 @default.
• W2118962787 hasConcept C164027704 @default.
• W2118962787 hasConcept C202751555 @default.
• W2118962787 hasConcept C203014093 @default.
• W2118962787 hasConcept C2776914184 @default.
• W2118962787 hasConcept C2776992346 @default.
• W2118962787 hasConcept C28005876 @default.
• W2118962787 hasConcept C39347974 @default.
• W2118962787 hasConcept C55493867 @default.
• W2118962787 hasConcept C62478195 @default.
• W2118962787 hasConcept C86803240 @default.

• next