Matches in SemOpenAlex for { <https://semopenalex.org/work/W2118970001> ?p ?o ?g. }
- W2118970001 endingPage "230" @default.
- W2118970001 startingPage "220" @default.
- W2118970001 abstract "The infiltration of leukocytes into the central nervous system (CNS) is an essential step in the neuropathogenesis of multiple sclerosis (MS). Leukocyte extravasation from the bloodstream is a multistep process that depends on several factors including fluid dynamics within the vasculature and molecular interactions between circulating leukocytes and the vascular endothelium. An important step in this cascade is the presence of chemokines on the vascular endothelial cell surface. Chemokines displayed along the endothelial lumen bind chemokine receptors on circulating leukocytes, initiating intracellular signaling that culminates in integrin activation, leukocyte arrest, and extravasation. The presence of chemokines at the endothelial lumen can help guide the movement of leukocytes through peripheral tissues during normal immune surveillance, host defense or inflammation. The expression and display of homeostatic or inflammatory chemokines therefore critically determine which leukocyte subsets extravasate and enter the peripheral tissues. Within the CNS, however, infiltrating leukocytes that cross the endothelium face additional boundaries to parenchymal entry, including the abluminal presence of localizing cues that prevent egress from perivascular spaces. This review focuses on the differential display of chemokines along endothelial surfaces and how they impact leukocyte extravasation into parenchymal tissues, especially within the CNS. In particular, the display of chemokines by endothelial cells of the blood brain barrier may be altered during CNS autoimmune disease, promoting leukocyte entry into this immunologically distinct site. Recent advances in microscopic techniques, including two-photon and intravital imaging have provided new insights into the mechanisms of chemokine-mediated capture of leukocytes within the CNS." @default.
- W2118970001 created "2016-06-24" @default.
- W2118970001 creator A5004190830 @default.
- W2118970001 creator A5034732141 @default.
- W2118970001 creator A5046722897 @default.
- W2118970001 date "2011-02-01" @default.
- W2118970001 modified "2023-09-26" @default.
- W2118970001 title "The blood–brain barrier, chemokines and multiple sclerosis" @default.
- W2118970001 cites W1499048493 @default.
- W2118970001 cites W1546001077 @default.
- W2118970001 cites W1548436366 @default.
- W2118970001 cites W1593489191 @default.
- W2118970001 cites W1629653839 @default.
- W2118970001 cites W1791569952 @default.
- W2118970001 cites W1843199965 @default.
- W2118970001 cites W1900061736 @default.
- W2118970001 cites W1907777909 @default.
- W2118970001 cites W1955666311 @default.
- W2118970001 cites W1965569135 @default.
- W2118970001 cites W1968099474 @default.
- W2118970001 cites W1971246306 @default.
- W2118970001 cites W1973613551 @default.
- W2118970001 cites W1973867020 @default.
- W2118970001 cites W1973891258 @default.
- W2118970001 cites W1975264481 @default.
- W2118970001 cites W1976936511 @default.
- W2118970001 cites W1977043587 @default.
- W2118970001 cites W1977679676 @default.
- W2118970001 cites W1977899668 @default.
- W2118970001 cites W1979670158 @default.
- W2118970001 cites W1979947689 @default.
- W2118970001 cites W1980731038 @default.
- W2118970001 cites W1981149366 @default.
- W2118970001 cites W1982467145 @default.
- W2118970001 cites W1986195187 @default.
- W2118970001 cites W1987265891 @default.
- W2118970001 cites W1989237374 @default.
- W2118970001 cites W1989528460 @default.
- W2118970001 cites W1991261634 @default.
- W2118970001 cites W1991666145 @default.
- W2118970001 cites W1993746949 @default.
- W2118970001 cites W1994995252 @default.
- W2118970001 cites W1995374504 @default.
- W2118970001 cites W1995446848 @default.
- W2118970001 cites W1996437925 @default.
- W2118970001 cites W1996722399 @default.
- W2118970001 cites W1999419270 @default.
- W2118970001 cites W2005375661 @default.
- W2118970001 cites W2006166044 @default.
- W2118970001 cites W2010075128 @default.
- W2118970001 cites W2010641543 @default.
- W2118970001 cites W2015343551 @default.
- W2118970001 cites W2015541518 @default.
- W2118970001 cites W2017830994 @default.
- W2118970001 cites W2020319641 @default.
- W2118970001 cites W2021877641 @default.
- W2118970001 cites W2025793780 @default.
- W2118970001 cites W2029779302 @default.
- W2118970001 cites W2029906813 @default.
- W2118970001 cites W2030490621 @default.
- W2118970001 cites W2031628629 @default.
- W2118970001 cites W2031703541 @default.
- W2118970001 cites W2031786917 @default.
- W2118970001 cites W2034387476 @default.
- W2118970001 cites W2035661165 @default.
- W2118970001 cites W2035809865 @default.
- W2118970001 cites W2036552682 @default.
- W2118970001 cites W2038937310 @default.
- W2118970001 cites W2040187962 @default.
- W2118970001 cites W2041264117 @default.
- W2118970001 cites W2046832348 @default.
- W2118970001 cites W2054542448 @default.
- W2118970001 cites W2056594677 @default.
- W2118970001 cites W2057682160 @default.
- W2118970001 cites W2058132087 @default.
- W2118970001 cites W2061814831 @default.
- W2118970001 cites W2061859660 @default.
- W2118970001 cites W2062296742 @default.
- W2118970001 cites W2064218663 @default.
- W2118970001 cites W2064668202 @default.
- W2118970001 cites W2065186655 @default.
- W2118970001 cites W2065344187 @default.
- W2118970001 cites W2067733328 @default.
- W2118970001 cites W2067810471 @default.
- W2118970001 cites W2068918480 @default.
- W2118970001 cites W2070105244 @default.
- W2118970001 cites W2071575257 @default.
- W2118970001 cites W2073809111 @default.
- W2118970001 cites W2078109197 @default.
- W2118970001 cites W2079316414 @default.
- W2118970001 cites W2080492861 @default.
- W2118970001 cites W2080932190 @default.
- W2118970001 cites W2081826751 @default.
- W2118970001 cites W2082475771 @default.
- W2118970001 cites W2083991999 @default.
- W2118970001 cites W2084862813 @default.
- W2118970001 cites W2086235904 @default.
- W2118970001 cites W2086237072 @default.