FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2118972462> ?p ?o ?g. }

• W2118972462 endingPage "70" @default.
• W2118972462 startingPage "962" @default.
• W2118972462 abstract "We have synthesized a series of hybrid polar compounds that induce differentiation and/or apoptosis of various transformed cells. These agents are also potent inhibitors of histone deacetylases (HDACs). Pyroxamide (suberoyl-3-aminopyridineamide hydroxamic acid) is a new member of this class of compounds that is currently under development as an anticancer agent. We investigated the activity of pyroxamide as an inducer of differentiation and/or apoptosis in transformed cells.Pyroxamide, at micromolar concentrations, induced terminal differentiation in murine erythroleukemia (MEL) cells and caused growth inhibition by cell cycle arrest and/or apoptosis in MEL, prostate carcinoma, bladder carcinoma, and neuroblastoma cells. Administration of pyroxamide (100 or 200 mg/kg/day) to nude mice at doses that caused little evident toxicity significantly suppressed the growth of s.c. CWR22 prostate cancer xenografts. Despite the potent growth-inhibitory effects of pyroxamide in this tumor model, serum prostate-specific antigen levels in control versus pyroxamide-treated mice were not significantly different. Pyroxamide is a potent inhibitor of affinity-purified HDAC1 (ID(50) = 100 nM) and causes the accumulation of acetylated core histones in MEL cells cultured with the agent. Human CWR22 prostate tumor xenografts from mice treated with pyroxamide (100 or 200 mg/kg/day) showed increased levels of histone acetylation and increased expression of the cell cycle regulator p21/WAF1, compared with tumors from vehicle-treated control animals.The findings suggest that pyroxamide may be a useful agent for the treatment of malignancy and that induction of p21/WAF1 in transformed cells by pyroxamide may contribute to the antitumor effects of this agent." @default.
• W2118972462 created "2016-06-24" @default.
• W2118972462 creator A5002140630 @default.
• W2118972462 creator A5009131648 @default.
• W2118972462 creator A5012095437 @default.
• W2118972462 creator A5027363771 @default.
• W2118972462 creator A5050075947 @default.
• W2118972462 creator A5053926080 @default.
• W2118972462 creator A5055051171 @default.
• W2118972462 creator A5055693211 @default.
• W2118972462 creator A5069180548 @default.
• W2118972462 creator A5072850546 @default.
• W2118972462 creator A5078159824 @default.
• W2118972462 creator A5080940311 @default.
• W2118972462 creator A5082113956 @default.
• W2118972462 creator A5084622204 @default.
• W2118972462 date "2001-04-01" @default.
• W2118972462 modified "2023-10-18" @default.
• W2118972462 title "Inhibition of transformed cell growth and induction of cellular differentiation by pyroxamide, an inhibitor of histone deacetylase." @default.
• W2118972462 cites W1484200362 @default.
• W2118972462 cites W1511815964 @default.
• W2118972462 cites W1541979189 @default.
• W2118972462 cites W1587031596 @default.
• W2118972462 cites W1609412760 @default.
• W2118972462 cites W1965490540 @default.
• W2118972462 cites W1979942191 @default.
• W2118972462 cites W1982619775 @default.
• W2118972462 cites W1997148771 @default.
• W2118972462 cites W1998475911 @default.
• W2118972462 cites W2006978594 @default.
• W2118972462 cites W2009616940 @default.
• W2118972462 cites W2016330660 @default.
• W2118972462 cites W2017109949 @default.
• W2118972462 cites W2032025865 @default.
• W2118972462 cites W2042327228 @default.
• W2118972462 cites W2047439581 @default.
• W2118972462 cites W2052115456 @default.
• W2118972462 cites W2080722423 @default.
• W2118972462 cites W2082739830 @default.
• W2118972462 cites W2095705375 @default.
• W2118972462 cites W2109589384 @default.
• W2118972462 cites W2113210499 @default.
• W2118972462 cites W2123245958 @default.
• W2118972462 cites W2123687793 @default.
• W2118972462 cites W2127286180 @default.
• W2118972462 cites W2135085078 @default.
• W2118972462 cites W2135830745 @default.
• W2118972462 cites W2148180201 @default.
• W2118972462 cites W2167118090 @default.
• W2118972462 cites W2172260980 @default.
• W2118972462 cites W2345727187 @default.
• W2118972462 cites W2399424572 @default.
• W2118972462 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/11309347" @default.
• W2118972462 hasPublicationYear "2001" @default.
• W2118972462 type Work @default.
• W2118972462 sameAs 2118972462 @default.
• W2118972462 citedByCount "34" @default.
• W2118972462 countsByYear W21189724622012 @default.
• W2118972462 countsByYear W21189724622013 @default.
• W2118972462 countsByYear W21189724622015 @default.
• W2118972462 countsByYear W21189724622017 @default.
• W2118972462 countsByYear W21189724622018 @default.
• W2118972462 countsByYear W21189724622019 @default.
• W2118972462 countsByYear W21189724622020 @default.
• W2118972462 countsByYear W21189724622023 @default.
• W2118972462 crossrefType "journal-article" @default.
• W2118972462 hasAuthorship W2118972462A5002140630 @default.
• W2118972462 hasAuthorship W2118972462A5009131648 @default.
• W2118972462 hasAuthorship W2118972462A5012095437 @default.
• W2118972462 hasAuthorship W2118972462A5027363771 @default.
• W2118972462 hasAuthorship W2118972462A5050075947 @default.
• W2118972462 hasAuthorship W2118972462A5053926080 @default.
• W2118972462 hasAuthorship W2118972462A5055051171 @default.
• W2118972462 hasAuthorship W2118972462A5055693211 @default.
• W2118972462 hasAuthorship W2118972462A5069180548 @default.
• W2118972462 hasAuthorship W2118972462A5072850546 @default.
• W2118972462 hasAuthorship W2118972462A5078159824 @default.
• W2118972462 hasAuthorship W2118972462A5080940311 @default.
• W2118972462 hasAuthorship W2118972462A5082113956 @default.
• W2118972462 hasAuthorship W2118972462A5084622204 @default.
• W2118972462 hasConcept C104317684 @default.
• W2118972462 hasConcept C119157956 @default.
• W2118972462 hasConcept C148738053 @default.
• W2118972462 hasConcept C185592680 @default.
• W2118972462 hasConcept C190283241 @default.
• W2118972462 hasConcept C2776202225 @default.
• W2118972462 hasConcept C2778305200 @default.
• W2118972462 hasConcept C29537977 @default.
• W2118972462 hasConcept C502942594 @default.
• W2118972462 hasConcept C55493867 @default.
• W2118972462 hasConcept C62112901 @default.
• W2118972462 hasConcept C64927066 @default.
• W2118972462 hasConcept C85240754 @default.
• W2118972462 hasConcept C86803240 @default.
• W2118972462 hasConceptScore W2118972462C104317684 @default.
• W2118972462 hasConceptScore W2118972462C119157956 @default.
• W2118972462 hasConceptScore W2118972462C148738053 @default.
• W2118972462 hasConceptScore W2118972462C185592680 @default.

• next