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- W2118972808 abstract "textabstractIt is hypothesized that childhood asthma, especially when not well controlled,may constitute a risk factor for the development of COLD in adulthood(Cropp, 1985), It is unknown whether lung injury during early life is a risk factorfor the development of COLD in adulthood, Asthma often starts before schoolage(Cropp, 1985), Except for the disturbing symptoms, a reason for paying attention to asthma in preschool children is the hypothesis that adequate interventionmay reduce the risk of COLD in adult life (Kerrebijn, 1982). To detect lungfunction abnormalities at as young as possible ages suitable methods should beavailable. Most lung function methods can only be performed in children over 6years of age.Lung function was measured with the forced pseudo-random noise oscillationtechnique (FOT) (Uindser et al., 1976a) because only passive cooperationis needed. Resistance (R,) and reactance (X,) of the respiratory system aresimultaneously measured over a frequency spectrum of 2 to 26 Hz. R, is mainlydetermined by the patency of the upper and large airways. X, is influenced bymass-inertial and elastic properties of the respiratory system.The applicability ofFOT in preschool children was investigated. The methodis now suitable for use in clinical practice to measure lung function and BR inchildren from about 2lfz years of age.We measured airway patency, bronchial smooth muscle tone and BR inpreschool asthmatic children. Secondly, we investigated whether lung injury duringearly influences the development of lung function and bronchial responsivenessin children who do not have a genetic predisposition of asthma.This was investigated in children who had infant bronchiolitis, in subjectswho survived infant bronchopulmonary dysplasia after neonatal respiratory distresssyndrome and in individuals who experienced a near-drowning accident.The results are compared to data found in healthy controls." @default.
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- W2118972808 date "1985-10-23" @default.
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- W2118972808 title "Lung function and bronchial responsiveness in preschool children" @default.
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