Matches in SemOpenAlex for { <https://semopenalex.org/work/W2118974576> ?p ?o ?g. }
- W2118974576 endingPage "13" @default.
- W2118974576 startingPage "3" @default.
- W2118974576 abstract "The lower urinary tract is a muscular system composed of the urinary bladder and the outflow tract. During filling with urine the bladder is relaxed and the outflow tract offers a high resistance; during emptying the outflow resistance falls and the bladder wall generates a high wall tension to raise intravesical pressure. The coordination of these responses is organized in the brainstem and sacral spinal cord to control the activity of autonomic and somatic efferents to the smooth muscle of the bladder (detrusor) and the smooth and skeletal muscle of the bladder base and urethra. Detrusor contraction is predominantly controlled by parasympathetic fibres releasing acetylcholine and ATP; the outflow tract is controlled by parasympathetic and sympathetic fibres to the bladder base (trigone) and urethral smooth muscle (including a nitregic component) and somatic fibres to the urethral rhabdosphincter. The smooth muscles also develop spontaneous contractions that determine the tone of the musculature. The cellular signaling pathways that evoke contraction due to neurotransmitter release and the origin of spontaneous activity are discussed, as well as the electrical properties of the smooth muscle relevant to the propagation of electrical signals. Finally the interaction of muscle cells with other cell types (epithelium and interstitial cells) is considered, relevant to their ability to regulate muscle contractility. Throughout, the basic physiological processes are considered in relation to pathological developments that are prevalent in the human lower urinary tract, in particular the overactive bladder and urinary incontinence, and the identification of drug targets to manage these conditions." @default.
- W2118974576 created "2016-06-24" @default.
- W2118974576 creator A5029328031 @default.
- W2118974576 creator A5037576261 @default.
- W2118974576 creator A5082938066 @default.
- W2118974576 date "2010-04-01" @default.
- W2118974576 modified "2023-10-16" @default.
- W2118974576 title "The physiological function of lower urinary tract smooth muscle" @default.
- W2118974576 cites W1500060932 @default.
- W2118974576 cites W1529741838 @default.
- W2118974576 cites W1556351201 @default.
- W2118974576 cites W156625477 @default.
- W2118974576 cites W1602123272 @default.
- W2118974576 cites W1606958661 @default.
- W2118974576 cites W1692427522 @default.
- W2118974576 cites W1839389203 @default.
- W2118974576 cites W1884483771 @default.
- W2118974576 cites W1967312126 @default.
- W2118974576 cites W1967347194 @default.
- W2118974576 cites W1968679642 @default.
- W2118974576 cites W1968771166 @default.
- W2118974576 cites W1970270099 @default.
- W2118974576 cites W1971879557 @default.
- W2118974576 cites W1972070631 @default.
- W2118974576 cites W1975019589 @default.
- W2118974576 cites W1975391576 @default.
- W2118974576 cites W1980242273 @default.
- W2118974576 cites W1981371957 @default.
- W2118974576 cites W1985689558 @default.
- W2118974576 cites W1987858646 @default.
- W2118974576 cites W1988165477 @default.
- W2118974576 cites W1989487812 @default.
- W2118974576 cites W1993476523 @default.
- W2118974576 cites W1994552851 @default.
- W2118974576 cites W1994846925 @default.
- W2118974576 cites W1995699497 @default.
- W2118974576 cites W2001068327 @default.
- W2118974576 cites W2001831364 @default.
- W2118974576 cites W2001913952 @default.
- W2118974576 cites W2002213265 @default.
- W2118974576 cites W2002975183 @default.
- W2118974576 cites W2003700491 @default.
- W2118974576 cites W2004809846 @default.
- W2118974576 cites W2006066953 @default.
- W2118974576 cites W2007886796 @default.
- W2118974576 cites W2008977920 @default.
- W2118974576 cites W2010783115 @default.
- W2118974576 cites W2011899523 @default.
- W2118974576 cites W2015552021 @default.
- W2118974576 cites W2015727883 @default.
- W2118974576 cites W2017353450 @default.
- W2118974576 cites W2018594575 @default.
- W2118974576 cites W2021611788 @default.
- W2118974576 cites W2022805390 @default.
- W2118974576 cites W2022864187 @default.
- W2118974576 cites W2032295238 @default.
- W2118974576 cites W2034301098 @default.
- W2118974576 cites W2039658671 @default.
- W2118974576 cites W2040249269 @default.
- W2118974576 cites W2040288000 @default.
- W2118974576 cites W2040652094 @default.
- W2118974576 cites W2041246673 @default.
- W2118974576 cites W2045252450 @default.
- W2118974576 cites W2048986589 @default.
- W2118974576 cites W2049313102 @default.
- W2118974576 cites W2050448556 @default.
- W2118974576 cites W2051893541 @default.
- W2118974576 cites W2052218834 @default.
- W2118974576 cites W2056123178 @default.
- W2118974576 cites W2059059882 @default.
- W2118974576 cites W2060083375 @default.
- W2118974576 cites W2063060988 @default.
- W2118974576 cites W2064276315 @default.
- W2118974576 cites W2064712924 @default.
- W2118974576 cites W2065006643 @default.
- W2118974576 cites W2065166325 @default.
- W2118974576 cites W2065986804 @default.
- W2118974576 cites W2068922363 @default.
- W2118974576 cites W2069032906 @default.
- W2118974576 cites W2069277569 @default.
- W2118974576 cites W2072088822 @default.
- W2118974576 cites W2072797090 @default.
- W2118974576 cites W2078593257 @default.
- W2118974576 cites W2078997630 @default.
- W2118974576 cites W2079406706 @default.
- W2118974576 cites W2080039022 @default.
- W2118974576 cites W2081251120 @default.
- W2118974576 cites W2083141179 @default.
- W2118974576 cites W2083514340 @default.
- W2118974576 cites W2084222484 @default.
- W2118974576 cites W2087760800 @default.
- W2118974576 cites W2092575413 @default.
- W2118974576 cites W2094461054 @default.
- W2118974576 cites W2094835702 @default.
- W2118974576 cites W2095937483 @default.
- W2118974576 cites W2100452437 @default.
- W2118974576 cites W2102464896 @default.
- W2118974576 cites W2104967317 @default.