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- W2118977260 abstract "Osmotic shock triggers eryptosis, a suicidal death of erythrocytes characterized by cell shrinkage, cell membrane blebbing and phosphatidylserine exposure at the cell surface. Phosphatidylserine-exposing erythrocytes are recognized by macrophages, engulfed, degraded and thus cleared from circulating blood. Eryptosis following osmotic shock is mediated by two distinct signalling pathways. On the one hand, osmotic shock stimulates a cyclooxygenase leading to formation of prostaglandin E2 and subsequent activation of Ca2+-permeable cation channels. On the other hand, osmotic shock activates a phospholipase A2 leading to release of platelet activating factor, which in turn activates a sphingomyelinase and thus stimulates the formation of ceramide. The increased cytosolic Ca2+ concentrations on the one hand and ceramide on the other trigger phospholipid scrambling of the cell membrane with the subsequent shift of phosphatidylserine from the inner to the outer cell membrane leaflet. Ca2+ further activates Ca2+-sensitive K+ channels leading to cellular KCl loss and further cell shrinkage. The cation channels are inhibited by Cl- anions, erythropoietin and dopamine. The sphingomyelinase is inhibited by high concentrations of urea. Thus, the high Cl- and urea concentrations in renal medulla presumably prevent the triggering of eryptosis despite hyperosmolarity. The mechanisms involved in eryptosis may not only affect the survival of erythrocytes but may be similarly operative in nucleated cells exposed to osmotic shock." @default.
- W2118977260 created "2016-06-24" @default.
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- W2118977260 date "2006-05-01" @default.
- W2118977260 modified "2023-10-17" @default.
- W2118977260 title "Osmotic shock‐induced suicidal death of erythrocytes" @default.
- W2118977260 cites W1500255296 @default.
- W2118977260 cites W155057202 @default.
- W2118977260 cites W1969120266 @default.
- W2118977260 cites W1969886439 @default.
- W2118977260 cites W1972748726 @default.
- W2118977260 cites W1973608456 @default.
- W2118977260 cites W1976466808 @default.
- W2118977260 cites W1979569515 @default.
- W2118977260 cites W1983418648 @default.
- W2118977260 cites W1985040456 @default.
- W2118977260 cites W1985345682 @default.
- W2118977260 cites W1991382760 @default.
- W2118977260 cites W1991870376 @default.
- W2118977260 cites W1994224570 @default.
- W2118977260 cites W1995870256 @default.
- W2118977260 cites W1996179257 @default.
- W2118977260 cites W1997129399 @default.
- W2118977260 cites W2003505368 @default.
- W2118977260 cites W2003693275 @default.
- W2118977260 cites W2010193398 @default.
- W2118977260 cites W2015717266 @default.
- W2118977260 cites W2015807826 @default.
- W2118977260 cites W2016558309 @default.
- W2118977260 cites W2019107970 @default.
- W2118977260 cites W2019471670 @default.
- W2118977260 cites W2020371872 @default.
- W2118977260 cites W2020796977 @default.
- W2118977260 cites W2026875866 @default.
- W2118977260 cites W2027851046 @default.
- W2118977260 cites W2030570585 @default.
- W2118977260 cites W2031809080 @default.
- W2118977260 cites W2033035828 @default.
- W2118977260 cites W2033982017 @default.
- W2118977260 cites W2035320088 @default.
- W2118977260 cites W2035341414 @default.
- W2118977260 cites W2038819783 @default.
- W2118977260 cites W2039506763 @default.
- W2118977260 cites W2039659095 @default.
- W2118977260 cites W2042948104 @default.
- W2118977260 cites W2043994824 @default.
- W2118977260 cites W2050036363 @default.
- W2118977260 cites W2052726190 @default.
- W2118977260 cites W2054934343 @default.
- W2118977260 cites W2065641335 @default.
- W2118977260 cites W2071085094 @default.
- W2118977260 cites W2074702983 @default.
- W2118977260 cites W2075822475 @default.
- W2118977260 cites W2076273704 @default.
- W2118977260 cites W2088533769 @default.
- W2118977260 cites W2089976554 @default.
- W2118977260 cites W2090277012 @default.
- W2118977260 cites W2095774705 @default.
- W2118977260 cites W2096188040 @default.
- W2118977260 cites W2098000156 @default.
- W2118977260 cites W2098612901 @default.
- W2118977260 cites W2101632221 @default.
- W2118977260 cites W2102640497 @default.
- W2118977260 cites W2102807564 @default.
- W2118977260 cites W2111015204 @default.
- W2118977260 cites W2113999599 @default.
- W2118977260 cites W2114705741 @default.
- W2118977260 cites W2127053772 @default.
- W2118977260 cites W2131523916 @default.
- W2118977260 cites W2132376575 @default.
- W2118977260 cites W2136690044 @default.
- W2118977260 cites W2138694854 @default.
- W2118977260 cites W2139953109 @default.
- W2118977260 cites W2148045277 @default.
- W2118977260 cites W2148394321 @default.
- W2118977260 cites W2153422264 @default.
- W2118977260 cites W2154766878 @default.
- W2118977260 cites W2155556672 @default.
- W2118977260 cites W2155670471 @default.
- W2118977260 cites W2158560112 @default.
- W2118977260 cites W2160154880 @default.
- W2118977260 cites W2162988042 @default.
- W2118977260 cites W2164890366 @default.
- W2118977260 cites W2165716800 @default.
- W2118977260 cites W2212457084 @default.
- W2118977260 cites W2224021986 @default.
- W2118977260 cites W2268409423 @default.
- W2118977260 cites W2317277068 @default.
- W2118977260 cites W2327002369 @default.
- W2118977260 cites W2336116827 @default.
- W2118977260 cites W4248717353 @default.
- W2118977260 cites W4255445767 @default.
- W2118977260 doi "https://doi.org/10.1111/j.1748-1716.2006.01564.x" @default.
- W2118977260 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/16734755" @default.