Matches in SemOpenAlex for { <https://semopenalex.org/work/W2118978691> ?p ?o ?g. }
Showing items 1 to 76 of
76
with 100 items per page.
- W2118978691 endingPage "330" @default.
- W2118978691 startingPage "324" @default.
- W2118978691 abstract "Objective: We have evaluated the effects of a new calcium channel blocker, manidipine, given at both high, hypotensive and low, non-hypotensive doses, on vascular morphology, response to endothelin-1 and ICAM-1 production in mesenteric small resistance arteries of spontaneously hypertensive rats (SHR). Methods: Ten SHR were treated with manidipine 3 mg/kg per day (high dose) and 10 with manidipine 0.3 mg/kg/ per day (low dose). The drug was administered by gavage from the 4th to 12th weeks of age. Eighteen Wistar-Kyoto (WKY) rats and 18 SHR were kept untreated as controls. Rats were killed at 13 weeks. Mesenteric small arteries were dissected and mounted on a micromyograph for determination of indexes of vascular structure (media thickness, wall thickness, media/lumen ratio). Results: Systolic blood pressure was significantly reduced by the high dose of the drug, while no effect was observed with low-dose manidipine. A reduction in the media/lumen ratio was observed only in SHR treated with high-dose manidipine. The response to endothelin-1 in untreated SHR was significantly lower in comparison with WKY; a significant reduction was observed in SHR treated with high-dose manidipine. ICAM-1 vascular concentrations were higher in untreated SHR than in WKY controls. Both high- and low-dose manidipine reduced ICAM-1 concentrations toward normalization. Conclusions: Manidipine at high, hypotensive, but not at low, non-hypotensive doses has been proven to reduce structural alterations in mesenteric small resistance arteries, and to normalize vascular responses to endothelin-1. In addition, manidipine, at both low and high doses, may reduce ICAM-1 vascular production, thus suggesting a possible anti-atherogenic effect." @default.
- W2118978691 created "2016-06-24" @default.
- W2118978691 creator A5010755470 @default.
- W2118978691 date "1998-01-01" @default.
- W2118978691 modified "2023-09-25" @default.
- W2118978691 title "Effects of Hypotensive and Non-hypotensive Doses of Manidipine on Structure, Responses to Endothelin-1 and ICAM-1 Production in Mesenteric Small Resistance Arteries of Spontaneously Hypertensive Rats" @default.
- W2118978691 cites W1578438134 @default.
- W2118978691 cites W1765750524 @default.
- W2118978691 cites W1970445852 @default.
- W2118978691 cites W1980588083 @default.
- W2118978691 cites W1994648099 @default.
- W2118978691 cites W2031513528 @default.
- W2118978691 cites W2053634688 @default.
- W2118978691 cites W2085271574 @default.
- W2118978691 cites W2085751107 @default.
- W2118978691 cites W2092394432 @default.
- W2118978691 cites W2104824409 @default.
- W2118978691 cites W2145622529 @default.
- W2118978691 cites W2326936669 @default.
- W2118978691 cites W2333143411 @default.
- W2118978691 cites W4232887427 @default.
- W2118978691 doi "https://doi.org/10.1080/080370598437204" @default.
- W2118978691 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/10321447" @default.
- W2118978691 hasPublicationYear "1998" @default.
- W2118978691 type Work @default.
- W2118978691 sameAs 2118978691 @default.
- W2118978691 citedByCount "10" @default.
- W2118978691 countsByYear W21189786912012 @default.
- W2118978691 countsByYear W21189786912015 @default.
- W2118978691 crossrefType "journal-article" @default.
- W2118978691 hasAuthorship W2118978691A5010755470 @default.
- W2118978691 hasBestOaLocation W21189786911 @default.
- W2118978691 hasConcept C120770815 @default.
- W2118978691 hasConcept C126322002 @default.
- W2118978691 hasConcept C134018914 @default.
- W2118978691 hasConcept C149601957 @default.
- W2118978691 hasConcept C170493617 @default.
- W2118978691 hasConcept C2776820930 @default.
- W2118978691 hasConcept C2778086073 @default.
- W2118978691 hasConcept C2780771799 @default.
- W2118978691 hasConcept C58245268 @default.
- W2118978691 hasConcept C71924100 @default.
- W2118978691 hasConcept C84393581 @default.
- W2118978691 hasConceptScore W2118978691C120770815 @default.
- W2118978691 hasConceptScore W2118978691C126322002 @default.
- W2118978691 hasConceptScore W2118978691C134018914 @default.
- W2118978691 hasConceptScore W2118978691C149601957 @default.
- W2118978691 hasConceptScore W2118978691C170493617 @default.
- W2118978691 hasConceptScore W2118978691C2776820930 @default.
- W2118978691 hasConceptScore W2118978691C2778086073 @default.
- W2118978691 hasConceptScore W2118978691C2780771799 @default.
- W2118978691 hasConceptScore W2118978691C58245268 @default.
- W2118978691 hasConceptScore W2118978691C71924100 @default.
- W2118978691 hasConceptScore W2118978691C84393581 @default.
- W2118978691 hasIssue "5-6" @default.
- W2118978691 hasLocation W21189786911 @default.
- W2118978691 hasLocation W21189786912 @default.
- W2118978691 hasOpenAccess W2118978691 @default.
- W2118978691 hasPrimaryLocation W21189786911 @default.
- W2118978691 hasRelatedWork W1972855773 @default.
- W2118978691 hasRelatedWork W2053560933 @default.
- W2118978691 hasRelatedWork W2053634688 @default.
- W2118978691 hasRelatedWork W2063224535 @default.
- W2118978691 hasRelatedWork W2091193686 @default.
- W2118978691 hasRelatedWork W2162471541 @default.
- W2118978691 hasRelatedWork W2171089442 @default.
- W2118978691 hasRelatedWork W2247177342 @default.
- W2118978691 hasRelatedWork W2412872739 @default.
- W2118978691 hasRelatedWork W3098085579 @default.
- W2118978691 hasVolume "7" @default.
- W2118978691 isParatext "false" @default.
- W2118978691 isRetracted "false" @default.
- W2118978691 magId "2118978691" @default.
- W2118978691 workType "article" @default.