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• W2118980692 abstract "The concept that a bolus of gonadotrophin-releasing hormone agonist (GnRHa) can replace human chorionic gonadotrophin (HCG) as a trigger of final oocyte maturation was introduced several years ago. Recent developments in the area strengthen this premise. GnRHa trigger offers important advantages, including virtually complete prevention of ovarian hyperstimulation syndrome (OHSS), the introduction of a surge of FSH in addition to the LH surge and finally the possibility to individualize luteal-phase supplementation based on ovarian response to stimulation. We maintain that the automatic HCG triggering concept should be challenged and that the GnRHa trigger is the way to move forward with thoughtful consideration of the needs, safety and comfort of our patients.Routinely, human chorionic gonadotrophin (HCG) is used to induce ovulation in fertility treatments. This approach deviates significantly from physiology and often results in insufficient hormonal support in early pregnancy and in ovarian hyperstimulation syndrome (OHSS). An alternative approach is to use a gonadotrophin-releasing hormone (GnRH) agonist which allows a more physiological trigger of ovulation and, most importantly, virtually eliminates the risk of OHSS. The current communication summarizes recent developments in the area and suggests future research efforts to enhance patients’ safety and comfort." @default.
• W2118980692 created "2016-06-24" @default.
• W2118980692 creator A5000419282 @default.
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• W2118980692 date "2013-03-01" @default.
• W2118980692 modified "2023-10-16" @default.
• W2118980692 title "GnRH agonist triggering: recent developments" @default.
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• W2118980692 doi "https://doi.org/10.1016/j.rbmo.2012.11.002" @default.
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