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- W2118986185 abstract "While Helicobacter pylori is accepted as the major bacterial agent of gastric disease in humans, some patients and many animals are infected with a larger, tightly helical-shaped bacterium previously referred to as ‘ Helicobacter heilmannii ’ or ‘ Gastrospirillum hominis ’. Taxonomic classification of these bacteria has been hampered by the inability to cultivate them in vitro and by the inadequate discriminatory power of 16S rRNA gene sequence analysis. This study describes the detection and phylogenetic analysis of 26 different gastrospirillum isolates from humans and animals, which incorporates sequence data based on the 16S rRNA and urease genes. Fifteen gastrospirilla detected in humans, primates and pigs clustered with ‘ Candidatus Helicobacter suis’, thus expanding the host range for this organism. By comparison, based on 16S rRNA data, the remaining 11 gastrospirilla could not be differentiated from Helicobacter felis , Helicobacter bizzozeronii and Helicobacter salomonis . However, urease gene sequence analysis allowed for the discrimination of this latter group into four discrete clusters, three of which contained the above recognized species. The fourth cluster contained isolates from human and feline hosts, and should provisionally be considered a unique bacterial species, for which the name ‘ Candidatus Helicobacter heilmannii’ is proposed." @default.
- W2118986185 created "2016-06-24" @default.
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- W2118986185 date "2004-11-01" @default.
- W2118986185 modified "2023-10-11" @default.
- W2118986185 title "Description of ‘Candidatus Helicobacter heilmannii’ based on DNA sequence analysis of 16S rRNA and urease genes" @default.
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- W2118986185 doi "https://doi.org/10.1099/ijs.0.63117-0" @default.
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