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- W2118997818 endingPage "L635" @default.
- W2118997818 startingPage "L625" @default.
- W2118997818 abstract "The pulmonary alveolus, terminal gas-exchange unit of the lung, is composed of alveolar epithelial and endothelial cells separated by a thin basement membrane and interstitial space. These cells participate in the maintenance of a delicate system regulated not only by biological factors but also by the mechanical environment of the lung, which undergoes dynamic deformation during breathing. Clinical and animal studies as well as cell culture studies point toward a strong influence of mechanical forces on lung cells and tissues including effects on growth and repair, surfactant release, injury, and inflammation. However, despite substantial advances in our understanding of lung mechanics over the last half century, there are still many unanswered questions regarding the micromechanics of the alveolus and how it deforms during lung inflation. Therefore, the aims of this review are to draw a multidisciplinary account of the mechanics of the alveolus on the basis of its structure, biology, and chemistry and to compare estimates of alveolar deformation from previous studies." @default.
- W2118997818 created "2016-06-24" @default.
- W2118997818 creator A5030126209 @default.
- W2118997818 creator A5077126677 @default.
- W2118997818 date "2011-11-01" @default.
- W2118997818 modified "2023-10-05" @default.
- W2118997818 title "What do we know about mechanical strain in lung alveoli?" @default.
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- W2118997818 doi "https://doi.org/10.1152/ajplung.00105.2011" @default.
- W2118997818 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3213982" @default.