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• W2118998050 abstract "Spleen and bone marrow (BM) are the major sites of antibody production and anamnestic response in systemically immunized mice. We examined the VDJ segment repertoire of antibody plaque-forming cells (APFC) in those two sites in the course of antibody responses to the hapten nitrophenyl (NP). Individual IgG APFC expressed any one of 10 VH segments of the V186.2/V3 (J558) gene family: 186.2, 102, 23, C1H4, 165.l, CH10, 3, 593.3, 24.8 and 671.5. The majority of cells in both spleen and BM expressed the V186.2 gene joined to a D segment with Tyr95. During a 2-month period after a single immunization, the V186.2+ APFC in BM accumulated 3 times as many somatic mutations than splenic APFC (average 8.5 versus 3 mutations/VH); this process was Th dependent as shown by in vivo depletion of CD4+ lymphocytes. However, the V186.2+ APFC in both spleen and BM shared a recurrent W33L replacement, indicating their common origin from germinal centers. The APFC expressing the other (analogue) VH segments were evenly represented in the spleen and BM, but they accumulated few, if any, mutations. The anamnestic V186.2+ APFC were highly mutated both in the spleen and BM; they represented a new and unexpected clonotype. The V/D segments were joined by Gly95 instead of Tyr95, the W33L was absent and a new shared K58R replacement appeared. The APFC expressing the `analogue' VH genes comprised ~20% of the anamnestic response and did not accumulate more mutations, but their affinities were in the range of the memory V186.2+ cells. These data suggest that the late primary and secondary responses to a hapten may be born by different B cell lineages, and that some clonotypes may reach the memory pool without an extensive mutation and expansion." @default.
• W2118998050 created "2016-06-24" @default.
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• W2118998050 date "2001-05-01" @default.
• W2118998050 modified "2023-10-11" @default.
• W2118998050 title "Canonical germinal center B cells may not dominate the memory response to antigenic challenge" @default.
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• W2118998050 cites W1523633230 @default.
• W2118998050 cites W1556648307 @default.
• W2118998050 cites W1565321014 @default.
• W2118998050 cites W1565367768 @default.
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• W2118998050 cites W1932248471 @default.
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• W2118998050 cites W1988062049 @default.
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• W2118998050 cites W1988903541 @default.
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• W2118998050 cites W1996967283 @default.
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• W2118998050 cites W2030816309 @default.
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• W2118998050 cites W2032381660 @default.
• W2118998050 cites W2036859226 @default.
• W2118998050 cites W2040671390 @default.
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• W2118998050 cites W2050772088 @default.
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• W2118998050 cites W2064421628 @default.
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• W2118998050 cites W2070646447 @default.
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• W2118998050 cites W2079633218 @default.
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• W2118998050 cites W2094664022 @default.
• W2118998050 cites W2095903025 @default.
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• W2118998050 doi "https://doi.org/10.1093/intimm/13.5.643" @default.
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