Matches in SemOpenAlex for { <https://semopenalex.org/work/W2119005306> ?p ?o ?g. }
- W2119005306 endingPage "20" @default.
- W2119005306 startingPage "13" @default.
- W2119005306 abstract "Background Depression is the most common psychiatric comorbidity in epilepsy patients. The lack of success with current pharmacological interventions for this patient population, highlights the importance of optimizing non-pharmacological neuromodulatory treatments such as vagus nerve stimulation (VNS). Studies on the antidepressant effect of VNS in epilepsy patients may be confounded by concurrent anti-epileptic drug therapy. To date, studies in epilepsy models overcoming this problem are lacking. Objective We investigated whether VNS affects anhedonia, a key symptom of major depression, in the kainic acid rat model for temporal lobe epilepsy. Methods Anhedonia was assessed in kainic acid (KA) and saline (SAL) injected rats using the saccharin preference test (SPT). To exclude differences in taste perception, the quinine aversion test (QAT) was performed. Both groups were randomly subdivided in a VNS and a SHAM group, yielding 4 experimental arms: KA-VNS, KA-SHAM, SAL-VNS and SAL-SHAM. Both VNS groups received 2 weeks of VNS, while the SHAM groups were not stimulated. Thereafter, the SPT and QAT were repeated. Results Saccharin preference was significantly reduced in the KA compared to the SAL rats (P < 0.05), without differences in quinine aversion. Two weeks of VNS significantly increased the saccharin preference in the KA-VNS group (P < 0.05), while it had no effect on quinine aversion. No effects of VNS or SHAM were found in the other groups. Conclusion The KA rats displayed anhedonia which was significantly decreased by VNS, indicating that this neuromodulatory treatment could likewise diminish depressive symptoms in patients suffering from temporal lobe epilepsy and comorbid depression." @default.
- W2119005306 created "2016-06-24" @default.
- W2119005306 creator A5005404511 @default.
- W2119005306 creator A5006345103 @default.
- W2119005306 creator A5009531136 @default.
- W2119005306 creator A5029948503 @default.
- W2119005306 creator A5031094049 @default.
- W2119005306 creator A5035157889 @default.
- W2119005306 creator A5037733924 @default.
- W2119005306 creator A5039470804 @default.
- W2119005306 creator A5057508554 @default.
- W2119005306 creator A5058815082 @default.
- W2119005306 creator A5087755849 @default.
- W2119005306 date "2015-01-01" @default.
- W2119005306 modified "2023-09-23" @default.
- W2119005306 title "Vagus Nerve Stimulation has Antidepressant Effects in the Kainic Acid Model for Temporal Lobe Epilepsy" @default.
- W2119005306 cites W140650021 @default.
- W2119005306 cites W1495293641 @default.
- W2119005306 cites W1568472238 @default.
- W2119005306 cites W1599114047 @default.
- W2119005306 cites W1607484169 @default.
- W2119005306 cites W1637705010 @default.
- W2119005306 cites W1858104813 @default.
- W2119005306 cites W1963549113 @default.
- W2119005306 cites W1963666492 @default.
- W2119005306 cites W1965258124 @default.
- W2119005306 cites W1966625822 @default.
- W2119005306 cites W1969000212 @default.
- W2119005306 cites W1971482087 @default.
- W2119005306 cites W1971517399 @default.
- W2119005306 cites W1972449722 @default.
- W2119005306 cites W1973825733 @default.
- W2119005306 cites W1973896888 @default.
- W2119005306 cites W1974153794 @default.
- W2119005306 cites W1976973106 @default.
- W2119005306 cites W1977430165 @default.
- W2119005306 cites W1978342674 @default.
- W2119005306 cites W1978441796 @default.
- W2119005306 cites W1980220707 @default.
- W2119005306 cites W1980438098 @default.
- W2119005306 cites W1980729833 @default.
- W2119005306 cites W1987908185 @default.
- W2119005306 cites W1990716006 @default.
- W2119005306 cites W1993217952 @default.
- W2119005306 cites W1994197562 @default.
- W2119005306 cites W1994284751 @default.
- W2119005306 cites W1995525413 @default.
- W2119005306 cites W2001446601 @default.
- W2119005306 cites W2002316736 @default.
- W2119005306 cites W2004581037 @default.
- W2119005306 cites W2006689666 @default.
- W2119005306 cites W2007250963 @default.
- W2119005306 cites W2007339452 @default.
- W2119005306 cites W2007556326 @default.
- W2119005306 cites W2010540814 @default.
- W2119005306 cites W2010914134 @default.
- W2119005306 cites W2011141235 @default.
- W2119005306 cites W2013235905 @default.
- W2119005306 cites W2015913538 @default.
- W2119005306 cites W2019943112 @default.
- W2119005306 cites W2020390719 @default.
- W2119005306 cites W2020482688 @default.
- W2119005306 cites W2021008834 @default.
- W2119005306 cites W2022981588 @default.
- W2119005306 cites W2026082008 @default.
- W2119005306 cites W2026099701 @default.
- W2119005306 cites W2027556287 @default.
- W2119005306 cites W2027571586 @default.
- W2119005306 cites W2035651669 @default.
- W2119005306 cites W2036405052 @default.
- W2119005306 cites W2040679499 @default.
- W2119005306 cites W2041352084 @default.
- W2119005306 cites W2043099835 @default.
- W2119005306 cites W2044664173 @default.
- W2119005306 cites W2045277530 @default.
- W2119005306 cites W2046227389 @default.
- W2119005306 cites W2047917340 @default.
- W2119005306 cites W2049108855 @default.
- W2119005306 cites W2050383009 @default.
- W2119005306 cites W2052264856 @default.
- W2119005306 cites W2052594619 @default.
- W2119005306 cites W2054963065 @default.
- W2119005306 cites W2055716589 @default.
- W2119005306 cites W2057230367 @default.
- W2119005306 cites W2057449233 @default.
- W2119005306 cites W2057970400 @default.
- W2119005306 cites W2058489875 @default.
- W2119005306 cites W2059560616 @default.
- W2119005306 cites W2060470243 @default.
- W2119005306 cites W2062149105 @default.
- W2119005306 cites W2063194861 @default.
- W2119005306 cites W2063773170 @default.
- W2119005306 cites W2064780317 @default.
- W2119005306 cites W2067099582 @default.
- W2119005306 cites W2068101716 @default.
- W2119005306 cites W2068213040 @default.
- W2119005306 cites W2069368135 @default.
- W2119005306 cites W2072269325 @default.