FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2119005391> ?p ?o ?g. }

• W2119005391 endingPage "3809" @default.
• W2119005391 startingPage "3801" @default.
• W2119005391 abstract "Genomic instability in colorectal cancer is categorized into two distinct classes: chromosome instability (CIN) and microsatellite instability (MSI). MSI is the result of mutations in the mismatch repair (MMR) machinery, whereas CIN is often thought to be associated with a disruption in the APC gene. Clinical data has recently shown the presence of heterozygous mutations in ATR and Chk1 in human cancers that exhibit MSI, suggesting that those mutations may contribute to tumorigenesis. To determine whether reduced activity in the DNA damage checkpoint pathway would cooperate with MMR deficiency to induce CIN, we used siRNA strategies to partially decrease the expression of ATR or Chk1 in MMR-deficient colorectal cancer cells. The resultant cancer cells display a typical CIN phenotype, as characterized by an increase in the number of chromosomal abnormalities. Importantly, restoration of MMR proficiency completely inhibited induction of the CIN phenotype, indicating that the combination of partial checkpoint blockage and MMR deficiency is necessary to trigger CIN. Moreover, disruption of ATR and Chk1 in MMR-deficient cells enhanced the sensitivity to treatment with the commonly used colorectal chemotherapeutic compound, 5-fluorouracil. These results provide a basis for the development of a combination therapy for those cancer patients." @default.
• W2119005391 created "2016-06-24" @default.
• W2119005391 creator A5005480293 @default.
• W2119005391 creator A5008869182 @default.
• W2119005391 creator A5016303261 @default.
• W2119005391 creator A5058268034 @default.
• W2119005391 creator A5065233200 @default.
• W2119005391 creator A5072233913 @default.
• W2119005391 date "2009-09-01" @default.
• W2119005391 modified "2023-10-18" @default.
• W2119005391 title "Reduced ATR or Chk1 Expression Leads to Chromosome Instability and Chemosensitization of Mismatch Repair–deficient Colorectal Cancer Cells" @default.
• W2119005391 cites W1903850103 @default.
• W2119005391 cites W1967743500 @default.
• W2119005391 cites W1968407767 @default.
• W2119005391 cites W1981567601 @default.
• W2119005391 cites W1990133999 @default.
• W2119005391 cites W1990850374 @default.
• W2119005391 cites W1990850872 @default.
• W2119005391 cites W1996367432 @default.
• W2119005391 cites W1998205845 @default.
• W2119005391 cites W1999403469 @default.
• W2119005391 cites W2006211525 @default.
• W2119005391 cites W2013000007 @default.
• W2119005391 cites W2021458266 @default.
• W2119005391 cites W2022408375 @default.
• W2119005391 cites W2035658950 @default.
• W2119005391 cites W2035765657 @default.
• W2119005391 cites W2037898576 @default.
• W2119005391 cites W2040795152 @default.
• W2119005391 cites W2042483691 @default.
• W2119005391 cites W2042879563 @default.
• W2119005391 cites W2051684942 @default.
• W2119005391 cites W2066065834 @default.
• W2119005391 cites W2078242581 @default.
• W2119005391 cites W2080308138 @default.
• W2119005391 cites W2092282016 @default.
• W2119005391 cites W2092989157 @default.
• W2119005391 cites W2093531978 @default.
• W2119005391 cites W2100499830 @default.
• W2119005391 cites W2104566573 @default.
• W2119005391 cites W2111772438 @default.
• W2119005391 cites W2115512932 @default.
• W2119005391 cites W2115984906 @default.
• W2119005391 cites W2119817121 @default.
• W2119005391 cites W2128252882 @default.
• W2119005391 cites W2132419347 @default.
• W2119005391 cites W2138214273 @default.
• W2119005391 cites W2141323033 @default.
• W2119005391 cites W2154141161 @default.
• W2119005391 cites W2154855968 @default.
• W2119005391 cites W2155820060 @default.
• W2119005391 cites W2161508400 @default.
• W2119005391 cites W2163529853 @default.
• W2119005391 cites W2164077501 @default.
• W2119005391 cites W2167196101 @default.
• W2119005391 cites W2329536997 @default.
• W2119005391 doi "https://doi.org/10.1091/mbc.e09-04-0303" @default.
• W2119005391 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2735479" @default.
• W2119005391 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/19570909" @default.
• W2119005391 hasPublicationYear "2009" @default.
• W2119005391 type Work @default.
• W2119005391 sameAs 2119005391 @default.
• W2119005391 citedByCount "28" @default.
• W2119005391 countsByYear W21190053912012 @default.
• W2119005391 countsByYear W21190053912013 @default.
• W2119005391 countsByYear W21190053912014 @default.
• W2119005391 countsByYear W21190053912015 @default.
• W2119005391 countsByYear W21190053912016 @default.
• W2119005391 countsByYear W21190053912017 @default.
• W2119005391 countsByYear W21190053912018 @default.
• W2119005391 countsByYear W21190053912019 @default.
• W2119005391 countsByYear W21190053912020 @default.
• W2119005391 countsByYear W21190053912021 @default.
• W2119005391 countsByYear W21190053912022 @default.
• W2119005391 countsByYear W21190053912023 @default.
• W2119005391 crossrefType "journal-article" @default.
• W2119005391 hasAuthorship W2119005391A5005480293 @default.
• W2119005391 hasAuthorship W2119005391A5008869182 @default.
• W2119005391 hasAuthorship W2119005391A5016303261 @default.
• W2119005391 hasAuthorship W2119005391A5058268034 @default.
• W2119005391 hasAuthorship W2119005391A5065233200 @default.
• W2119005391 hasAuthorship W2119005391A5072233913 @default.
• W2119005391 hasBestOaLocation W21190053912 @default.
• W2119005391 hasConcept C104317684 @default.
• W2119005391 hasConcept C105696609 @default.
• W2119005391 hasConcept C121608353 @default.
• W2119005391 hasConcept C127716648 @default.
• W2119005391 hasConcept C134935766 @default.
• W2119005391 hasConcept C140752955 @default.
• W2119005391 hasConcept C143425029 @default.
• W2119005391 hasConcept C178169997 @default.
• W2119005391 hasConcept C180754005 @default.
• W2119005391 hasConcept C2779767149 @default.
• W2119005391 hasConcept C29537977 @default.
• W2119005391 hasConcept C30481170 @default.
• W2119005391 hasConcept C50001416 @default.
• W2119005391 hasConcept C501734568 @default.
• W2119005391 hasConcept C502942594 @default.

• next