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• W2119008464 abstract "The transcription factor CCAAT/enhancer binding protein a (C/EBPα) is important in the regulation of granulopoiesis and is disrupted in human acute myeloid leukemia. In the present study, we sought to identify novel C/EBPα interacting proteins in vivo through immunoprecipitation using mass spectrometry-based proteomic techniques. We identified Max, a heterodimeric partner of Myc, as one of the interacting proteins of C/EBPα in our screen. We confirmed the in vivo interaction of C/EBPα with Max and showed that this interaction involves the basic region of C/EBPα. Endogenous C/EBPα and Max, but not Myc and Max, colocalize in intranuclear structures during granulocytic differentiation of myeloid U937 cells. Max enhanced the transactivation capacity of C/EBPα on a minimal promoter. A chromatin immunoprecipitation assay revealed occupancy of the human C/EBPα promoter in vivo by Max and Myc under cellular settings and by C/EBPα and Max under retinoic acid induced granulocytic differentiation. Interestingly, enforced expression of Max and C/EBPα results in granulocytic differentiation of the human hematopoietic CD34+ cells, as evidenced by CD11b, CD15 and granulocyte colony-stimulating factor receptor expression. Silencing of Max by short hairpin RNA in CD34+ and U937 cells strongly reduced the differentiation-inducing potential of C/EBPα, indicating the importance of C/EBPα–Max in myeloid progenitor differentiation. Taken together, our data reveal Max as a novel co-activator of C/EBPα functions, thereby suggesting a possible link between C/EBPα and Myc–Max–Mad network." @default.
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• W2119008464 date "2006-11-02" @default.
• W2119008464 modified "2023-10-13" @default.
• W2119008464 title "Proteomic discovery of Max as a novel interacting partner of C/EBPα: a Myc/Max/Mad link" @default.
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• W2119008464 doi "https://doi.org/10.1038/sj.leu.2404438" @default.
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