Matches in SemOpenAlex for { <https://semopenalex.org/work/W2119032769> ?p ?o ?g. }
- W2119032769 endingPage "2511" @default.
- W2119032769 startingPage "2498" @default.
- W2119032769 abstract "ABSTRACT Borrelia burgdorferi , the causative agent of Lyme disease in the United States, regulates numerous genes encoding lipoproteins on linear plasmid 54 in response to environmental cues. We analyzed a subset of these genes/proteins that were historically categorized as paralogous gene family 54 (BBA64, BBA65, BBA66, BBA68, BBA69, BBA70, BBA71, and BBA73) and found that the expression of several genes was influenced by the σ N -σ S regulatory cascade at the level of transcription and protein synthesis. Moreover, we established in this and a previous study that BBA65, BBA66, BBA69, BBA71, and BBA73 are temporally expressed during persistent infection of immunocompetent mice, as determined by quantitative real time-PCR of ear tissue, by enzyme-linked immunosorbent assay, and by immunoblotting. Correspondingly, BBA65, BBA66, BBA71, and BBA73 proteins were detectable in infectious B. burgdorferi B31 isolates but undetectable in noninfectious isolates. BBA65, BBA66, BBA71, and BBA73 proteins were also found to partition into the Triton X-114 detergent phase and were sensitive to protease treatment of intact cells, indicating that they are membrane associated and surface localized. Lastly, Southern blotting and PCR with specific gene primer/probes for BBA64, BBA65, BBA66, BBA71, and BBA73 suggest that many of these genes are conserved among the B. burgdorferi sensu lato isolates and the relapsing-fever Borrelia species. Together, the data presented suggest that these genes may play a part in Borrelia infection and/or pathogenicity that could extend beyond the sensu lato group." @default.
- W2119032769 created "2016-06-24" @default.
- W2119032769 creator A5005475489 @default.
- W2119032769 creator A5006544024 @default.
- W2119032769 creator A5025000097 @default.
- W2119032769 creator A5032477603 @default.
- W2119032769 creator A5034972188 @default.
- W2119032769 creator A5057277849 @default.
- W2119032769 creator A5059949227 @default.
- W2119032769 creator A5087563394 @default.
- W2119032769 date "2008-06-01" @default.
- W2119032769 modified "2023-10-16" @default.
- W2119032769 title "<i>Borrelia burgdorferi</i> Surface-Localized Proteins Expressed during Persistent Murine Infection Are Conserved among Diverse <i>Borrelia</i> spp" @default.
- W2119032769 cites W1486542000 @default.
- W2119032769 cites W1504104494 @default.
- W2119032769 cites W1558037037 @default.
- W2119032769 cites W1561668184 @default.
- W2119032769 cites W1595818143 @default.
- W2119032769 cites W1673951151 @default.
- W2119032769 cites W1691830123 @default.
- W2119032769 cites W1723696742 @default.
- W2119032769 cites W1841384971 @default.
- W2119032769 cites W1843280659 @default.
- W2119032769 cites W1847932176 @default.
- W2119032769 cites W1912214366 @default.
- W2119032769 cites W1922236261 @default.
- W2119032769 cites W1926303070 @default.
- W2119032769 cites W1969694089 @default.
- W2119032769 cites W1977904572 @default.
- W2119032769 cites W1980379844 @default.
- W2119032769 cites W1983831412 @default.
- W2119032769 cites W1986984168 @default.
- W2119032769 cites W1989599765 @default.
- W2119032769 cites W1995740522 @default.
- W2119032769 cites W1997698750 @default.
- W2119032769 cites W1999354584 @default.
- W2119032769 cites W1999500526 @default.
- W2119032769 cites W2005562463 @default.
- W2119032769 cites W2018046614 @default.
- W2119032769 cites W2018179967 @default.
- W2119032769 cites W2019962465 @default.
- W2119032769 cites W2022013307 @default.
- W2119032769 cites W2027669213 @default.
- W2119032769 cites W2031423487 @default.
- W2119032769 cites W2037310526 @default.
- W2119032769 cites W2043454090 @default.
- W2119032769 cites W2063367477 @default.
- W2119032769 cites W2071337207 @default.
- W2119032769 cites W2088089656 @default.
- W2119032769 cites W2093538084 @default.
- W2119032769 cites W2098179358 @default.
- W2119032769 cites W2101037008 @default.
- W2119032769 cites W2101108802 @default.
- W2119032769 cites W2101640708 @default.
- W2119032769 cites W2102707088 @default.
- W2119032769 cites W2103025674 @default.
- W2119032769 cites W2103234099 @default.
- W2119032769 cites W2105281406 @default.
- W2119032769 cites W2106036767 @default.
- W2119032769 cites W2107277218 @default.
- W2119032769 cites W2107943123 @default.
- W2119032769 cites W2108861047 @default.
- W2119032769 cites W2111305802 @default.
- W2119032769 cites W2111485154 @default.
- W2119032769 cites W2111489112 @default.
- W2119032769 cites W2112125190 @default.
- W2119032769 cites W2113658789 @default.
- W2119032769 cites W2114228461 @default.
- W2119032769 cites W2115840790 @default.
- W2119032769 cites W2118783042 @default.
- W2119032769 cites W2121726441 @default.
- W2119032769 cites W2122860405 @default.
- W2119032769 cites W2124242639 @default.
- W2119032769 cites W2124475162 @default.
- W2119032769 cites W2125811166 @default.
- W2119032769 cites W2126830973 @default.
- W2119032769 cites W2129892588 @default.
- W2119032769 cites W2130326600 @default.
- W2119032769 cites W2131778683 @default.
- W2119032769 cites W2135605184 @default.
- W2119032769 cites W2139636209 @default.
- W2119032769 cites W2139687638 @default.
- W2119032769 cites W2141013229 @default.
- W2119032769 cites W2142117803 @default.
- W2119032769 cites W2142125142 @default.
- W2119032769 cites W2146745552 @default.
- W2119032769 cites W2151239002 @default.
- W2119032769 cites W2154021037 @default.
- W2119032769 cites W2157352746 @default.
- W2119032769 cites W2159609005 @default.
- W2119032769 cites W2159988642 @default.
- W2119032769 cites W2160286580 @default.
- W2119032769 cites W2160384143 @default.
- W2119032769 cites W2161746138 @default.
- W2119032769 cites W2162299380 @default.
- W2119032769 cites W2163428114 @default.
- W2119032769 cites W2166361383 @default.
- W2119032769 cites W2167682215 @default.