Matches in SemOpenAlex for { <https://semopenalex.org/work/W2119035325> ?p ?o ?g. }
- W2119035325 endingPage "91" @default.
- W2119035325 startingPage "77" @default.
- W2119035325 abstract "How extracellular cues are transduced to the nucleus is a fundamental issue in biology. The paralogous WW-domain proteins YAP (Yes-associated protein) and TAZ (transcriptional coactivator with PDZ-binding motif; also known as WWTR1, for WW-domain containing transcription regulator 1) constitute a pair of transducers linking cytoplasmic signaling events to transcriptional regulation in the nucleus. A cascade composed of mammalian Ste20-like (MST) and large tumor suppressor (LATS) kinases directs multisite phosphorylation, promotes 14-3-3 binding, and hinders nuclear import of YAP and TAZ, thereby inhibiting their transcriptional coactivator and growth-promoting activities. A similar cascade regulates the trafficking and function of Yorkie, the fly orthologue of YAP. Mammalian YAP and TAZ are expressed in various tissues and serve as coregulators for transcriptional enhancer factors (TEFs; also referred to as TEADs, for TEA-domain proteins), runt-domain transcription factors (Runxs), peroxisome proliferator-activated receptor gamma (PPARgamma), T-box transcription factor 5 (Tbx5), and several others. YAP and TAZ play distinct roles during mouse development. Both, and their upstream regulators, are intimately linked to tumorigenesis and other pathogenic processes. Here, we review studies on this family of signal-responsive transcriptional coregulators and emphasize how relative sequence conservation predicates their function and regulation, to provide a conceptual framework for organizing available information and seeking new knowledge about these signal transducers." @default.
- W2119035325 created "2016-06-24" @default.
- W2119035325 creator A5021477828 @default.
- W2119035325 creator A5032500191 @default.
- W2119035325 creator A5052378792 @default.
- W2119035325 creator A5084553697 @default.
- W2119035325 date "2009-02-01" @default.
- W2119035325 modified "2023-10-07" @default.
- W2119035325 title "YAP, TAZ, and Yorkie: a conserved family of signal-responsive transcriptional coregulators in animal development and human diseaseThis paper is one of a selection of papers published in this Special Issue, entitled CSBMCB’s 51st Annual Meeting – Epigenetics and Chromatin Dynamics, and has undergone the Journal’s usual peer review process." @default.
- W2119035325 cites W1542760571 @default.
- W2119035325 cites W1567765448 @default.
- W2119035325 cites W1583737662 @default.
- W2119035325 cites W1597992152 @default.
- W2119035325 cites W1604166471 @default.
- W2119035325 cites W1912766252 @default.
- W2119035325 cites W1962669878 @default.
- W2119035325 cites W1964694209 @default.
- W2119035325 cites W1969579081 @default.
- W2119035325 cites W1974673111 @default.
- W2119035325 cites W1975284118 @default.
- W2119035325 cites W1976990850 @default.
- W2119035325 cites W1977306646 @default.
- W2119035325 cites W1978746441 @default.
- W2119035325 cites W1982498121 @default.
- W2119035325 cites W1984282087 @default.
- W2119035325 cites W1986676916 @default.
- W2119035325 cites W1987049707 @default.
- W2119035325 cites W1987304444 @default.
- W2119035325 cites W1988805210 @default.
- W2119035325 cites W1990324370 @default.
- W2119035325 cites W1991550774 @default.
- W2119035325 cites W1995267967 @default.
- W2119035325 cites W1997835441 @default.
- W2119035325 cites W1997973068 @default.
- W2119035325 cites W1998310906 @default.
- W2119035325 cites W2000225283 @default.
- W2119035325 cites W2002071844 @default.
- W2119035325 cites W2003044806 @default.
- W2119035325 cites W2007455356 @default.
- W2119035325 cites W2008920883 @default.
- W2119035325 cites W2011818472 @default.
- W2119035325 cites W2012858641 @default.
- W2119035325 cites W2018619568 @default.
- W2119035325 cites W2022423243 @default.
- W2119035325 cites W2023775321 @default.
- W2119035325 cites W2027928327 @default.
- W2119035325 cites W2029650615 @default.
- W2119035325 cites W2030433725 @default.
- W2119035325 cites W2031674791 @default.
- W2119035325 cites W2033440293 @default.
- W2119035325 cites W2034614265 @default.
- W2119035325 cites W2034820114 @default.
- W2119035325 cites W2035358499 @default.
- W2119035325 cites W2038441458 @default.
- W2119035325 cites W2042922488 @default.
- W2119035325 cites W2046152939 @default.
- W2119035325 cites W2046985565 @default.
- W2119035325 cites W2047757959 @default.
- W2119035325 cites W2048472525 @default.
- W2119035325 cites W2049378557 @default.
- W2119035325 cites W2050552243 @default.
- W2119035325 cites W2051200214 @default.
- W2119035325 cites W2055378633 @default.
- W2119035325 cites W2056182849 @default.
- W2119035325 cites W2060020667 @default.
- W2119035325 cites W2061428351 @default.
- W2119035325 cites W2063955955 @default.
- W2119035325 cites W2064207737 @default.
- W2119035325 cites W2067813923 @default.
- W2119035325 cites W2072795230 @default.
- W2119035325 cites W2073157874 @default.
- W2119035325 cites W2073568903 @default.
- W2119035325 cites W2076629995 @default.
- W2119035325 cites W2079174004 @default.
- W2119035325 cites W2079943669 @default.
- W2119035325 cites W2080329327 @default.
- W2119035325 cites W2081490489 @default.
- W2119035325 cites W2083106714 @default.
- W2119035325 cites W2085197940 @default.
- W2119035325 cites W2085250524 @default.
- W2119035325 cites W2091054780 @default.
- W2119035325 cites W2091621334 @default.
- W2119035325 cites W2097192405 @default.
- W2119035325 cites W2098069596 @default.
- W2119035325 cites W2099072529 @default.
- W2119035325 cites W2099709490 @default.
- W2119035325 cites W2101538557 @default.
- W2119035325 cites W2106029142 @default.
- W2119035325 cites W2111104542 @default.
- W2119035325 cites W2113037810 @default.
- W2119035325 cites W2118611175 @default.
- W2119035325 cites W2118671972 @default.
- W2119035325 cites W2123511906 @default.
- W2119035325 cites W2124196467 @default.
- W2119035325 cites W2127314696 @default.
- W2119035325 cites W2130746708 @default.
- W2119035325 cites W2131484319 @default.
- W2119035325 cites W2133811885 @default.