Matches in SemOpenAlex for { <https://semopenalex.org/work/W2119075172> ?p ?o ?g. }
Showing items 1 to 89 of
89
with 100 items per page.
- W2119075172 endingPage "182" @default.
- W2119075172 startingPage "177" @default.
- W2119075172 abstract "A subset of hemophilia B patients have a prolonged bovine-brain prothrombin time. These CRM+ patients are classified as having hemophilia Bm. The prolongation of the prothrombin time has been reported only with bovine brain (referred to as ox brain in some literature) as the source of thromboplastin; prothrombin times determined with thromboplastin from rabbit brain or human brain are not reported to be prolonged. Factor IX from a hemophilia Bm patient (factor IX Hilo) was isolated. The activity of factor IX Hilo was compared to that of normal factor IX in prothrombin time assays when the thromboplastin source was of bovine, rabbit, or human origin. Factor IX, either normal or Hilo, prolonged a prothrombin time regardless of the tissue factor source. However, unless thromboplastin was from a bovine source, this prolongation required high concentrations of factor IX. Further, factor IX normal was as effective as factor IX Hilo in prolonging the prothrombin time when rabbit or human thromboplastin was used. With bovine thromboplastin, factor IX Hilo was significantly better than factor IX normal at prolonging the prothrombin time. The amount of prolongation was dependent on the amount of factor IX Hilo added. In addition, the prolongation was dependent on the concentration of factor × present in the sample. The prothrombin time changed as much as 20 seconds when the factor × concentration was varied from 50% to 150% to normal (fixed concentration of factor IX Hilo). These results demonstrate the difficulty of classifying the severity of a hemophilia Bm patient based on the bovine brain prothrombin time unless both the factor IX and factor × concentrations are known." @default.
- W2119075172 created "2016-06-24" @default.
- W2119075172 creator A5051841089 @default.
- W2119075172 creator A5074574903 @default.
- W2119075172 creator A5086411107 @default.
- W2119075172 creator A5088954638 @default.
- W2119075172 date "1993-07-01" @default.
- W2119075172 modified "2023-09-25" @default.
- W2119075172 title "Comparison of the behavior of normal factor IX and the factor IX BM variant hilo in the prothrombin time test using tissue factors from bovine, human, and rabbit sources" @default.
- W2119075172 cites W1524896367 @default.
- W2119075172 cites W1541664337 @default.
- W2119075172 cites W1724686013 @default.
- W2119075172 cites W1966875441 @default.
- W2119075172 cites W1982213247 @default.
- W2119075172 cites W1993592526 @default.
- W2119075172 cites W2032827914 @default.
- W2119075172 cites W2062220640 @default.
- W2119075172 cites W2067391256 @default.
- W2119075172 cites W2095088651 @default.
- W2119075172 cites W2295080980 @default.
- W2119075172 cites W2329226239 @default.
- W2119075172 cites W2336344274 @default.
- W2119075172 cites W2409020234 @default.
- W2119075172 cites W2409842860 @default.
- W2119075172 cites W2417696606 @default.
- W2119075172 cites W2472426052 @default.
- W2119075172 cites W30338701 @default.
- W2119075172 cites W4239701749 @default.
- W2119075172 cites W4240758260 @default.
- W2119075172 cites W97897255 @default.
- W2119075172 doi "https://doi.org/10.1002/ajh.2830430304" @default.
- W2119075172 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/8352232" @default.
- W2119075172 hasPublicationYear "1993" @default.
- W2119075172 type Work @default.
- W2119075172 sameAs 2119075172 @default.
- W2119075172 citedByCount "7" @default.
- W2119075172 countsByYear W21190751722016 @default.
- W2119075172 countsByYear W21190751722021 @default.
- W2119075172 crossrefType "journal-article" @default.
- W2119075172 hasAuthorship W2119075172A5051841089 @default.
- W2119075172 hasAuthorship W2119075172A5074574903 @default.
- W2119075172 hasAuthorship W2119075172A5086411107 @default.
- W2119075172 hasAuthorship W2119075172A5088954638 @default.
- W2119075172 hasConcept C126322002 @default.
- W2119075172 hasConcept C144594695 @default.
- W2119075172 hasConcept C186738567 @default.
- W2119075172 hasConcept C2777292125 @default.
- W2119075172 hasConcept C2777444498 @default.
- W2119075172 hasConcept C2778261982 @default.
- W2119075172 hasConcept C2778382381 @default.
- W2119075172 hasConcept C2780434524 @default.
- W2119075172 hasConcept C2780930249 @default.
- W2119075172 hasConcept C2781221834 @default.
- W2119075172 hasConcept C71924100 @default.
- W2119075172 hasConcept C89560881 @default.
- W2119075172 hasConceptScore W2119075172C126322002 @default.
- W2119075172 hasConceptScore W2119075172C144594695 @default.
- W2119075172 hasConceptScore W2119075172C186738567 @default.
- W2119075172 hasConceptScore W2119075172C2777292125 @default.
- W2119075172 hasConceptScore W2119075172C2777444498 @default.
- W2119075172 hasConceptScore W2119075172C2778261982 @default.
- W2119075172 hasConceptScore W2119075172C2778382381 @default.
- W2119075172 hasConceptScore W2119075172C2780434524 @default.
- W2119075172 hasConceptScore W2119075172C2780930249 @default.
- W2119075172 hasConceptScore W2119075172C2781221834 @default.
- W2119075172 hasConceptScore W2119075172C71924100 @default.
- W2119075172 hasConceptScore W2119075172C89560881 @default.
- W2119075172 hasIssue "3" @default.
- W2119075172 hasLocation W21190751721 @default.
- W2119075172 hasLocation W21190751722 @default.
- W2119075172 hasOpenAccess W2119075172 @default.
- W2119075172 hasPrimaryLocation W21190751721 @default.
- W2119075172 hasRelatedWork W1927338422 @default.
- W2119075172 hasRelatedWork W1992910301 @default.
- W2119075172 hasRelatedWork W2002002930 @default.
- W2119075172 hasRelatedWork W2019235807 @default.
- W2119075172 hasRelatedWork W2070386451 @default.
- W2119075172 hasRelatedWork W2071069799 @default.
- W2119075172 hasRelatedWork W2119075172 @default.
- W2119075172 hasRelatedWork W2409716430 @default.
- W2119075172 hasRelatedWork W2503742714 @default.
- W2119075172 hasRelatedWork W4255941595 @default.
- W2119075172 hasVolume "43" @default.
- W2119075172 isParatext "false" @default.
- W2119075172 isRetracted "false" @default.
- W2119075172 magId "2119075172" @default.
- W2119075172 workType "article" @default.