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- W2119089438 abstract "20-(S)-Camptothecin (CPT)-conjugated dipeptides are reported that preassemble into nanotubes with diameters ranging from 80–120 nm. These nanoassemblies maintain a high (∼47 %) drug loading and exhibit greater drug stability (i.e., resistance to lactone hydrolysis), and consequently greater efficacy against several human cancer cells (HT-29, A549, H460, and H23) in vitro compared with the clinically used prodrug irinotecan. A key and defining feature of this system is the use of the CPT-conjugated dipeptide as both the drug and precursor to the nanostructured carrier, which simplifies the overall fabrication process." @default.
- W2119089438 created "2016-06-24" @default.
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- W2119089438 date "2014-11-10" @default.
- W2119089438 modified "2023-10-17" @default.
- W2119089438 title "The Self-Assembly of Anticancer Camptothecin-Dipeptide Nanotubes: A Minimalistic and High Drug Loading Approach to Increased Efficacy" @default.
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- W2119089438 doi "https://doi.org/10.1002/chem.201404520" @default.
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