FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2119094411> ?p ?o ?g. }

• W2119094411 endingPage "224" @default.
• W2119094411 startingPage "212" @default.
• W2119094411 abstract "The effects of a noncompetitive N-methyl-D-aspartate (NMDA) receptor antagonist dizocilpine ((+)-MK-801) and a competitive NMDA antagonist, (±)-3–2-carboxypiperazin-4-yl-propyl-1-phosphonic acid (CPP) were compared in electrically evoked 5-HT release in the brain slices incorporating the substantia nigra pars reticulata (SNr) or the dorsal raphé nucleus (DRN) using fast cyclic voltammetry (FCV). Electrical stimulation of either the SNr or the DRN with 50 pulses at frequencies greater than 10 Hz generated signals that were indistinguishable from 5-HT. In the SNr, 0.6–60 μM MK-801 concentration dependently potentiated stimulated 5-HT release. CPP 20 μM or NMDA 100 μM had no effect on 5-HT release evoked by electrical stimulation. In the SNr, 1 μM fluvoxamine or 0.6–60 μM MK-801 potentiated electrically evoked release of 5-HT. Pre-exposure to 20 μM MK-801 inhibited the enhancing effects of 1 μM fluvoxamine on electrically evoked 5-HT release in the SNr. In the DRN, the presence of 1 μM fluvoxamine or 20 μM MK-801 weakly potentiated 5-HT release. In the presence of 1 μM methiothepin (a nonselective 5-HT1–2 antagonist), 1μM fluvoxamine or 20 μM MK-801 were equipotent in potentiating the concentration of 5-HT released in response to electrical stimulation. The T1/2 values for 5-HT release following MK-801 or fluvoxamine administration were significantly increased. Potentiation of 5-HT release by MK-801 in the SNr and the DRN and lack of effect of either CPP or NMDA on 5-HT release or uptake argues against a role for NMDA receptors in modulation of 5-HT release. Inhibition of fluvoxamine induced potentiation of 5-HT signal in the presence of MK-801 suggests that MK-801 and fluvoxamine may interact at the level of the 5-HT transporter. Synapse 32:212–224, 1999. © 1999 Wiley-Liss, Inc." @default.
• W2119094411 created "2016-06-24" @default.
• W2119094411 creator A5013470252 @default.
• W2119094411 creator A5027015404 @default.
• W2119094411 creator A5037954759 @default.
• W2119094411 date "1999-06-01" @default.
• W2119094411 modified "2023-10-14" @default.
• W2119094411 title "MK-801 interaction with the 5-HT transporter: a real-time study in brain slices using fast cyclic voltammetry" @default.
• W2119094411 cites W1499761920 @default.
• W2119094411 cites W1591523569 @default.
• W2119094411 cites W1633847368 @default.
• W2119094411 cites W191918832 @default.
• W2119094411 cites W1949404224 @default.
• W2119094411 cites W1963749842 @default.
• W2119094411 cites W1964235419 @default.
• W2119094411 cites W1968956259 @default.
• W2119094411 cites W1969326071 @default.
• W2119094411 cites W1970433763 @default.
• W2119094411 cites W1971638658 @default.
• W2119094411 cites W1971851906 @default.
• W2119094411 cites W1971866692 @default.
• W2119094411 cites W1974275241 @default.
• W2119094411 cites W1974703596 @default.
• W2119094411 cites W1974836820 @default.
• W2119094411 cites W1974869837 @default.
• W2119094411 cites W1975316434 @default.
• W2119094411 cites W1979359907 @default.
• W2119094411 cites W1979564774 @default.
• W2119094411 cites W1981661367 @default.
• W2119094411 cites W1983632128 @default.
• W2119094411 cites W1984511767 @default.
• W2119094411 cites W1985094327 @default.
• W2119094411 cites W1985964337 @default.
• W2119094411 cites W1986096376 @default.
• W2119094411 cites W1987817512 @default.
• W2119094411 cites W1989625146 @default.
• W2119094411 cites W1992894736 @default.
• W2119094411 cites W1995056605 @default.
• W2119094411 cites W1995246557 @default.
• W2119094411 cites W1997243628 @default.
• W2119094411 cites W2004748949 @default.
• W2119094411 cites W2005976531 @default.
• W2119094411 cites W2006415628 @default.
• W2119094411 cites W2006912081 @default.
• W2119094411 cites W2009798253 @default.
• W2119094411 cites W2011434472 @default.
• W2119094411 cites W2013058093 @default.
• W2119094411 cites W2013332572 @default.
• W2119094411 cites W2016723993 @default.
• W2119094411 cites W2017492579 @default.
• W2119094411 cites W2018691353 @default.
• W2119094411 cites W2019623334 @default.
• W2119094411 cites W2020460680 @default.
• W2119094411 cites W2026632750 @default.
• W2119094411 cites W2027671925 @default.
• W2119094411 cites W2033525233 @default.
• W2119094411 cites W2035151323 @default.
• W2119094411 cites W2035298791 @default.
• W2119094411 cites W2035622704 @default.
• W2119094411 cites W2037060024 @default.
• W2119094411 cites W2038584409 @default.
• W2119094411 cites W2040533406 @default.
• W2119094411 cites W2040798945 @default.
• W2119094411 cites W2046188669 @default.
• W2119094411 cites W2051664368 @default.
• W2119094411 cites W2053204189 @default.
• W2119094411 cites W2053877593 @default.
• W2119094411 cites W2054401306 @default.
• W2119094411 cites W2058859392 @default.
• W2119094411 cites W2060040098 @default.
• W2119094411 cites W2060498734 @default.
• W2119094411 cites W2060718831 @default.
• W2119094411 cites W2061502491 @default.
• W2119094411 cites W2063164578 @default.
• W2119094411 cites W2063593286 @default.
• W2119094411 cites W2064770927 @default.
• W2119094411 cites W2066127633 @default.
• W2119094411 cites W2068216696 @default.
• W2119094411 cites W2068548329 @default.
• W2119094411 cites W2069597920 @default.
• W2119094411 cites W2070801110 @default.
• W2119094411 cites W2073725845 @default.
• W2119094411 cites W2078305868 @default.
• W2119094411 cites W2082772209 @default.
• W2119094411 cites W2085730376 @default.
• W2119094411 cites W2089586255 @default.
• W2119094411 cites W2090483863 @default.
• W2119094411 cites W2091153095 @default.
• W2119094411 cites W2091889367 @default.
• W2119094411 cites W2093202434 @default.
• W2119094411 cites W2093324918 @default.
• W2119094411 cites W2094126290 @default.
• W2119094411 cites W2095558927 @default.
• W2119094411 cites W2116634575 @default.
• W2119094411 cites W2120257264 @default.
• W2119094411 cites W2139358610 @default.
• W2119094411 cites W2155036206 @default.
• W2119094411 cites W2158137297 @default.

• next