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- W2119102310 abstract "Phosphodiesterase 4 (PDE4) is a major cyclic adenosine-3',5'-monophosphate-metabolizing enzyme in immune and inflammatory cells, airway smooth muscle, and pulmonary nerves. Selective inhibitors of this enzyme have been available for a number of years and show a broad spectrum of activity in animal models of COPD and asthma. The class-associated side effects, mainly nausea and emesis, appear to have been at least partially overcome by the so-called second-generation PDE4 inhibitors. Currently, three companies are in the later stages of development of candidate second-generation PDE4 inhibitors for the treatment of COPD patients. The preclinical profile of one of these, BAY 19-8004, is summarized below. The initial clinical data on the most advanced compound, cilomilast, were indeed encouraging. However, full knowledge of the therapeutic value of this novel compound class awaits the outcome of longer term clinical trials." @default.
- W2119102310 created "2016-06-24" @default.
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- W2119102310 date "2002-05-01" @default.
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- W2119102310 title "Phosphodiesterase 4 Inhibitors for the Treatment of COPD" @default.
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- W2119102310 doi "https://doi.org/10.1378/chest.121.5_suppl.192s" @default.
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