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- W2119106204 abstract "Ten volunteers were given 2 mg scopolamine intravenously (IV) to produce substantial drowsiness and sleepiness. Galanthamine, 0.5 mg/kg IV, effectively reversed the central anticholinergic syndrome produced by scopolamine. Electroencephalographic monitoring of two subjects matched the observed changes of consciousness: scopolamine replaced the dominant awake alpha rhythm with a disorganized, slow, 4- to 6-Hz activity. Galanthamine promptly returned the EEG pattern to the control, awake state. Galanthamine produces effective, safe, and long-lasting reversal of the central anticholinergic syndrome in man. (<i>JAMA</i>238:2293-2294, 1977)" @default.
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- W2119106204 date "1977-11-21" @default.
- W2119106204 modified "2023-10-10" @default.
- W2119106204 title "Reversal of Central Anticholinergic Syndrome by Galanthamine" @default.
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- W2119106204 doi "https://doi.org/10.1001/jama.1977.03280220061024" @default.
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