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• W2119109339 endingPage "12377" @default.
• W2119109339 startingPage "12367" @default.
• W2119109339 abstract "The time-dependent effects of ethanol (EtOH) intoxication on GABA A receptor (GABA A R) composition and function were studied in rats. A cross-linking assay and Western blot analysis of microdissected CA1 area of hippocampal slices obtained 1 h after EtOH intoxication (5 g/kg, gavage), revealed decreases in the cell-surface fraction of α4 and δ, but not α1, α5, or γ2 GABA A R subunits, without changes in their total content. This was accompanied (in CA1 neuron recordings) by decreased magnitude of the picrotoxin-sensitive tonic current ( I tonic ), but not miniature IPSCs (mIPSCs), and by reduced enhancement of I tonic by EtOH, but not by diazepam. By 48 h after EtOH dosing, cell-surface α4 (80%) and γ2 (82%) subunit content increased, and cell-surface α1 (−50%) and δ (−79%) and overall content were decreased. This was paralleled by faster decay of mIPSCs, decreased diazepam enhancement of both mIPSCs and I tonic , and paradoxically increased mIPSC responsiveness to EtOH (10–100 m m ). Sensitivity to isoflurane- or diazepam-induced loss of righting reflex was decreased at 12 and 24 h after EtOH intoxication, respectively, suggesting functional GABA A R tolerance. The plastic GABA A R changes were gradually and fully reversible by 2 weeks after single EtOH dosing, but unexplainably persisted long after withdrawal from chronic intermittent ethanol treatment, which leads to signs of alcohol dependence. Our data suggest that early tolerance to EtOH may result from excessive activation and subsequent internalization of α4βδ extrasynaptic GABA A Rs. This leads to transcriptionally regulated increases in α4 and γ2 and decreases in α1 subunits, with preferential insertion of the newly formed α4βγ2 GABA A Rs at synapses." @default.
• W2119109339 created "2016-06-24" @default.
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• W2119109339 creator A5070139382 @default.
• W2119109339 date "2007-11-07" @default.
• W2119109339 modified "2023-10-18" @default.
• W2119109339 title "Mechanisms of Reversible GABA_AReceptor Plasticity after Ethanol Intoxication" @default.
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• W2119109339 cites W1691674240 @default.
• W2119109339 cites W1771372085 @default.
• W2119109339 cites W1821749400 @default.
• W2119109339 cites W1879000632 @default.
• W2119109339 cites W1932887997 @default.
• W2119109339 cites W1965832299 @default.
• W2119109339 cites W1967380120 @default.
• W2119109339 cites W1968059634 @default.
• W2119109339 cites W1968579780 @default.
• W2119109339 cites W1970978793 @default.
• W2119109339 cites W1975743909 @default.
• W2119109339 cites W1977640681 @default.
• W2119109339 cites W1979560116 @default.
• W2119109339 cites W1980333362 @default.
• W2119109339 cites W1980471589 @default.
• W2119109339 cites W1980819328 @default.
• W2119109339 cites W1984110918 @default.
• W2119109339 cites W1989591866 @default.
• W2119109339 cites W1990846589 @default.
• W2119109339 cites W1995541582 @default.
• W2119109339 cites W1997723786 @default.
• W2119109339 cites W1997801680 @default.
• W2119109339 cites W1998419939 @default.
• W2119109339 cites W2002293846 @default.
• W2119109339 cites W2004166962 @default.
• W2119109339 cites W2004546862 @default.
• W2119109339 cites W2009410204 @default.
• W2119109339 cites W2009548083 @default.
• W2119109339 cites W2011961236 @default.
• W2119109339 cites W2014065544 @default.
• W2119109339 cites W2016321438 @default.
• W2119109339 cites W2019043248 @default.
• W2119109339 cites W2021194790 @default.
• W2119109339 cites W2022185308 @default.
• W2119109339 cites W2023132644 @default.
• W2119109339 cites W2029215893 @default.
• W2119109339 cites W2032093027 @default.
• W2119109339 cites W2033812532 @default.
• W2119109339 cites W2040444580 @default.
• W2119109339 cites W2042393295 @default.
• W2119109339 cites W2042507192 @default.
• W2119109339 cites W2050526784 @default.
• W2119109339 cites W2052438768 @default.
• W2119109339 cites W2055223893 @default.
• W2119109339 cites W2059100550 @default.
• W2119109339 cites W2061947653 @default.
• W2119109339 cites W2062186332 @default.
• W2119109339 cites W2064150096 @default.
• W2119109339 cites W2066394439 @default.
• W2119109339 cites W2072454094 @default.
• W2119109339 cites W2075450210 @default.
• W2119109339 cites W2077488853 @default.
• W2119109339 cites W2088143216 @default.
• W2119109339 cites W2097917275 @default.
• W2119109339 cites W2101235918 @default.
• W2119109339 cites W2103799984 @default.
• W2119109339 cites W2104180855 @default.
• W2119109339 cites W2104685361 @default.
• W2119109339 cites W2119677026 @default.
• W2119109339 cites W2121429100 @default.
• W2119109339 cites W2126532122 @default.
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• W2119109339 cites W2131231986 @default.
• W2119109339 cites W2132457456 @default.
• W2119109339 cites W2136807926 @default.
• W2119109339 cites W2138788537 @default.
• W2119109339 cites W2140256470 @default.
• W2119109339 cites W2171381392 @default.
• W2119109339 cites W2240658239 @default.
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• W2119109339 doi "https://doi.org/10.1523/jneurosci.2786-07.2007" @default.
• W2119109339 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6673253" @default.
• W2119109339 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/17989301" @default.
• W2119109339 hasPublicationYear "2007" @default.
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