FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2119149016> ?p ?o ?g. }

• W2119149016 endingPage "G507" @default.
• W2119149016 startingPage "G501" @default.
• W2119149016 abstract "The action potential in gallbladder smooth muscle (GBSM) is caused by Ca2+ entry through voltage-dependent Ca2+ channels (VDCC), which contributes to the GBSM contractions. Action potential generation in GBSM is critically dependent on the resting membrane potential (about -50 mV), which is approximately 35 mV more positive of the K+ equilibrium potential. We hypothesized that a tonic, depolarizing conductance is present in GBSM and contributes to the regulation of the resting membrane potential and action potential frequency. GBSM cells were isolated from guinea pig gallbladders, and the whole cell patch-camp technique was used to record membrane currents. After eliminating the contribution of VDCC and K+ channels, we identified a novel spontaneously active cation conductance (I(cat)) in GBSM. This I(cat) was mediated predominantly by influx of Na+. Na+ substitution with N-methyl-D-glucamine (NMDG), a large relatively impermeant cation, caused a negative shift in the reversal potential of the ramp current and reduced the amplitude of the inward current at -50 mV by 65%. Membrane potential recordings with intracellular microelectrodes or in current-clamp mode of the patch-clamp technique indicated that the inhibition of I(cat) conductance by NMDG is associated with membrane hyperpolarization and inhibition of action potentials. Extracellular Ca2+, Mg2+, and Gd3+ attenuated the I(cat) in GBSM. Muscarinic stimulation did not activate the I(cat). Our results indicate that, in GBSM, an Na+-permeable channel contributes to the maintenance of the resting membrane potential and action potential generation and therefore plays a critical role in the regulation of GBSM excitability and contractility." @default.
• W2119149016 created "2016-06-24" @default.
• W2119149016 creator A5047096678 @default.
• W2119149016 creator A5048090770 @default.
• W2119149016 creator A5051518430 @default.
• W2119149016 creator A5085753911 @default.
• W2119149016 date "2005-09-01" @default.
• W2119149016 modified "2023-09-30" @default.
• W2119149016 title "Identification of a spontaneously active, Na⁺-permeable channel in guinea pig gallbladder smooth muscle" @default.
• W2119149016 cites W1608043820 @default.
• W2119149016 cites W1748265667 @default.
• W2119149016 cites W1971788599 @default.
• W2119149016 cites W1979744443 @default.
• W2119149016 cites W1984746596 @default.
• W2119149016 cites W1996903305 @default.
• W2119149016 cites W2001989240 @default.
• W2119149016 cites W2008578618 @default.
• W2119149016 cites W2010795846 @default.
• W2119149016 cites W2014101284 @default.
• W2119149016 cites W2017909256 @default.
• W2119149016 cites W2024850338 @default.
• W2119149016 cites W2029518460 @default.
• W2119149016 cites W2031329023 @default.
• W2119149016 cites W2050852850 @default.
• W2119149016 cites W2077716740 @default.
• W2119149016 cites W2078248237 @default.
• W2119149016 cites W2090677452 @default.
• W2119149016 cites W2094526206 @default.
• W2119149016 cites W2095718116 @default.
• W2119149016 cites W2097033636 @default.
• W2119149016 cites W2107793814 @default.
• W2119149016 cites W2142704391 @default.
• W2119149016 cites W2161358101 @default.
• W2119149016 cites W2181410479 @default.
• W2119149016 cites W2261634273 @default.
• W2119149016 cites W2262822371 @default.
• W2119149016 cites W2289052846 @default.
• W2119149016 cites W2420619354 @default.
• W2119149016 cites W342778569 @default.
• W2119149016 doi "https://doi.org/10.1152/ajpgi.00140.2005" @default.
• W2119149016 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/15920017" @default.
• W2119149016 hasPublicationYear "2005" @default.
• W2119149016 type Work @default.
• W2119149016 sameAs 2119149016 @default.
• W2119149016 citedByCount "16" @default.
• W2119149016 countsByYear W21191490162012 @default.
• W2119149016 countsByYear W21191490162013 @default.
• W2119149016 countsByYear W21191490162020 @default.
• W2119149016 countsByYear W21191490162023 @default.
• W2119149016 crossrefType "journal-article" @default.
• W2119149016 hasAuthorship W2119149016A5047096678 @default.
• W2119149016 hasAuthorship W2119149016A5048090770 @default.
• W2119149016 hasAuthorship W2119149016A5051518430 @default.
• W2119149016 hasAuthorship W2119149016A5085753911 @default.
• W2119149016 hasConcept C114614502 @default.
• W2119149016 hasConcept C121932024 @default.
• W2119149016 hasConcept C12554922 @default.
• W2119149016 hasConcept C131453863 @default.
• W2119149016 hasConcept C146403970 @default.
• W2119149016 hasConcept C147944092 @default.
• W2119149016 hasConcept C158494493 @default.
• W2119149016 hasConcept C169760540 @default.
• W2119149016 hasConcept C170493617 @default.
• W2119149016 hasConcept C181911157 @default.
• W2119149016 hasConcept C185263204 @default.
• W2119149016 hasConcept C185592680 @default.
• W2119149016 hasConcept C2778071365 @default.
• W2119149016 hasConcept C33923547 @default.
• W2119149016 hasConcept C4141045 @default.
• W2119149016 hasConcept C55493867 @default.
• W2119149016 hasConcept C66974803 @default.
• W2119149016 hasConcept C71240020 @default.
• W2119149016 hasConcept C79879829 @default.
• W2119149016 hasConcept C86803240 @default.
• W2119149016 hasConceptScore W2119149016C114614502 @default.
• W2119149016 hasConceptScore W2119149016C121932024 @default.
• W2119149016 hasConceptScore W2119149016C12554922 @default.
• W2119149016 hasConceptScore W2119149016C131453863 @default.
• W2119149016 hasConceptScore W2119149016C146403970 @default.
• W2119149016 hasConceptScore W2119149016C147944092 @default.
• W2119149016 hasConceptScore W2119149016C158494493 @default.
• W2119149016 hasConceptScore W2119149016C169760540 @default.
• W2119149016 hasConceptScore W2119149016C170493617 @default.
• W2119149016 hasConceptScore W2119149016C181911157 @default.
• W2119149016 hasConceptScore W2119149016C185263204 @default.
• W2119149016 hasConceptScore W2119149016C185592680 @default.
• W2119149016 hasConceptScore W2119149016C2778071365 @default.
• W2119149016 hasConceptScore W2119149016C33923547 @default.
• W2119149016 hasConceptScore W2119149016C4141045 @default.
• W2119149016 hasConceptScore W2119149016C55493867 @default.
• W2119149016 hasConceptScore W2119149016C66974803 @default.
• W2119149016 hasConceptScore W2119149016C71240020 @default.
• W2119149016 hasConceptScore W2119149016C79879829 @default.
• W2119149016 hasConceptScore W2119149016C86803240 @default.
• W2119149016 hasIssue "3" @default.
• W2119149016 hasLocation W21191490161 @default.
• W2119149016 hasLocation W21191490162 @default.
• W2119149016 hasOpenAccess W2119149016 @default.

• next