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• W2119153314 endingPage "L361" @default.
• W2119153314 startingPage "L347" @default.
• W2119153314 abstract "The relative contribution of inositol 1,4,5-trisphosphate (IP 3 ) receptors (IP 3 Rs) and ryanodine receptors (RyRs) to agonist-induced Ca 2+ signaling in mouse airway smooth muscle cells (SMCs) was investigated in lung slices with phase-contrast or laser scanning microscopy. At room temperature (RT), methacholine (MCh) or 5-hydroxytryptamine (5-HT) induced Ca 2+ oscillations and an associated contraction in small airway SMCs. The subsequent exposure to an IP 3 R antagonist, 2-aminoethoxydiphenyl borate (2-APB), inhibited the Ca 2+ oscillations and induced airway relaxation in a concentration-dependent manner. 2-APB also inhibited Ca 2+ waves generated by the photolytic release of IP 3 . However, the RyR antagonist ryanodine had no significant effect, at any concentration, on airway contraction or agonist- or IP 3 -induced Ca 2+ oscillations or Ca 2+ wave propagation. By contrast, a second RyR antagonist, tetracaine, relaxed agonist-contracted airways and inhibited agonist-induced Ca 2+ oscillations in a concentration-dependent manner. However, tetracaine did not affect IP 3 -induced Ca 2+ release or wave propagation nor the Ca 2+ content of SMC Ca 2+ stores as evaluated by Ca 2+ -release induced by caffeine. Conversely, both ryanodine and tetracaine completely blocked agonist-independent slow Ca 2+ oscillations induced by KCl. The inhibitory effects of 2-APB and absence of an effect of ryanodine on MCh-induced airway contraction or Ca 2+ oscillations of SMCs were also observed at 37°C. In Ca 2+ -permeable SMCs, tetracaine inhibited agonist-induced contraction without affecting intracellular Ca 2+ levels indicating that relaxation also resulted from a reduction in Ca 2+ sensitivity. These results indicate that agonist-induced Ca 2+ oscillations in mouse small airway SMCs are primary mediated via IP 3 Rs and that tetracaine induces relaxation by both decreasing Ca 2+ sensitivity and inhibiting agonist-induced Ca 2+ oscillations via an IP 3 -dependent mechanism." @default.
• W2119153314 created "2016-06-24" @default.
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• W2119153314 date "2009-08-01" @default.
• W2119153314 modified "2023-10-16" @default.
• W2119153314 title "The contribution of inositol 1,4,5-trisphosphate and ryanodine receptors to agonist-induced Ca²⁺ signaling of airway smooth muscle cells" @default.
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• W2119153314 doi "https://doi.org/10.1152/ajplung.90559.2008" @default.
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