FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2119178573> ?p ?o ?g. }

• W2119178573 endingPage "28" @default.
• W2119178573 startingPage "28" @default.
• W2119178573 abstract "Although the importance of proteins of the biomineral organic matrix and their posttranslational modifications for biomineralization is generally recognized, the number of published matrix proteomes is still small. This is mostly due to the lack of comprehensive sequence databases, usually derived from genomic sequencing projects. However, in-depth mass spectrometry-based proteomic analysis, which critically depends on high-quality sequence databases, is a very fast tool to identify candidates for functional biomineral matrix proteins and their posttranslational modifications. Identification of such candidate proteins is facilitated by at least approximate quantitation of the identified proteins, because the most abundant ones may also be the most interesting candidates for further functional analysis.Re-quantification of previously identified Lottia shell matrix proteins using the intensity-based absolute quantification (iBAQ) method as implemented in the MaxQuant identification and quantitation software showed that only 57 of the 382 accepted identifications constituted 98% of the total identified matrix proteome. This group of proteins did not contain obvious intracellular proteins, such as cytoskeletal components or ribosomal proteins, invariably identified as minor components of high-throughput biomineral matrix proteomes. Fourteen of these major proteins were phosphorylated to a variable extent. All together we identified 52 phospho sites in 20 of the 382 accepted proteins with high confidence.We show that iBAQ quantitation may be a useful tool to narrow down the group of functional biomineral matrix protein candidates for further research in cell biology, genetics or materials research. Knowledge of posttranslational modifications in these major proteins could be a valuable addition to previously published proteomes. This is true especially for phosphorylation, because this modification was already shown to modify mineralization processes in some instances." @default.
• W2119178573 created "2016-06-24" @default.
• W2119178573 creator A5008191906 @default.
• W2119178573 creator A5084074748 @default.
• W2119178573 date "2014-01-01" @default.
• W2119178573 modified "2023-10-05" @default.
• W2119178573 title "The Lottia gigantea shell matrix proteome: re-analysis including MaxQuant iBAQ quantitation and phosphoproteome analysis" @default.
• W2119178573 cites W1536886974 @default.
• W2119178573 cites W1556673877 @default.
• W2119178573 cites W1567785877 @default.
• W2119178573 cites W1828052768 @default.
• W2119178573 cites W1903485990 @default.
• W2119178573 cites W1971588558 @default.
• W2119178573 cites W1973500743 @default.
• W2119178573 cites W1973661625 @default.
• W2119178573 cites W1978089096 @default.
• W2119178573 cites W1978757322 @default.
• W2119178573 cites W1979731014 @default.
• W2119178573 cites W1986656413 @default.
• W2119178573 cites W1989059075 @default.
• W2119178573 cites W1989235034 @default.
• W2119178573 cites W2004118070 @default.
• W2119178573 cites W2008214517 @default.
• W2119178573 cites W2008304717 @default.
• W2119178573 cites W2018247248 @default.
• W2119178573 cites W2020447501 @default.
• W2119178573 cites W2032431407 @default.
• W2119178573 cites W2036321220 @default.
• W2119178573 cites W2037199116 @default.
• W2119178573 cites W2038747075 @default.
• W2119178573 cites W2040328099 @default.
• W2119178573 cites W2042357131 @default.
• W2119178573 cites W2045990697 @default.
• W2119178573 cites W2060390097 @default.
• W2119178573 cites W2073179024 @default.
• W2119178573 cites W2073523429 @default.
• W2119178573 cites W2077038946 @default.
• W2119178573 cites W2080752012 @default.
• W2119178573 cites W2085097771 @default.
• W2119178573 cites W2085997090 @default.
• W2119178573 cites W2086643274 @default.
• W2119178573 cites W2086802118 @default.
• W2119178573 cites W2094201044 @default.
• W2119178573 cites W2098325756 @default.
• W2119178573 cites W2099255819 @default.
• W2119178573 cites W2101633640 @default.
• W2119178573 cites W2102986338 @default.
• W2119178573 cites W2103794130 @default.
• W2119178573 cites W2104391291 @default.
• W2119178573 cites W2107644675 @default.
• W2119178573 cites W2110863368 @default.
• W2119178573 cites W2124081847 @default.
• W2119178573 cites W2125574061 @default.
• W2119178573 cites W2127322768 @default.
• W2119178573 cites W2128016775 @default.
• W2119178573 cites W2128551987 @default.
• W2119178573 cites W2129241692 @default.
• W2119178573 cites W2129754968 @default.
• W2119178573 cites W2133447659 @default.
• W2119178573 cites W2133500918 @default.
• W2119178573 cites W2141426301 @default.
• W2119178573 cites W2148490163 @default.
• W2119178573 cites W2155521690 @default.
• W2119178573 cites W2156407548 @default.
• W2119178573 cites W2159167011 @default.
• W2119178573 cites W2167350014 @default.
• W2119178573 cites W2169150541 @default.
• W2119178573 cites W2476181897 @default.
• W2119178573 cites W2498106431 @default.
• W2119178573 cites W2898553790 @default.
• W2119178573 cites W744677427 @default.
• W2119178573 doi "https://doi.org/10.1186/1477-5956-12-28" @default.
• W2119178573 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4094399" @default.
• W2119178573 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/25018669" @default.
• W2119178573 hasPublicationYear "2014" @default.
• W2119178573 type Work @default.
• W2119178573 sameAs 2119178573 @default.
• W2119178573 citedByCount "57" @default.
• W2119178573 countsByYear W21191785732015 @default.
• W2119178573 countsByYear W21191785732016 @default.
• W2119178573 countsByYear W21191785732017 @default.
• W2119178573 countsByYear W21191785732018 @default.
• W2119178573 countsByYear W21191785732019 @default.
• W2119178573 countsByYear W21191785732020 @default.
• W2119178573 countsByYear W21191785732021 @default.
• W2119178573 countsByYear W21191785732022 @default.
• W2119178573 countsByYear W21191785732023 @default.
• W2119178573 crossrefType "journal-article" @default.
• W2119178573 hasAuthorship W2119178573A5008191906 @default.
• W2119178573 hasAuthorship W2119178573A5084074748 @default.
• W2119178573 hasBestOaLocation W21191785731 @default.
• W2119178573 hasConcept C104317684 @default.
• W2119178573 hasConcept C104397665 @default.
• W2119178573 hasConcept C105686024 @default.
• W2119178573 hasConcept C106487976 @default.
• W2119178573 hasConcept C185592680 @default.
• W2119178573 hasConcept C43617362 @default.
• W2119178573 hasConcept C46111723 @default.

• next