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• W2119248051 endingPage "659" @default.
• W2119248051 startingPage "655" @default.
• W2119248051 abstract "Lysophospholipids regulate a wide array of biological processes including cell survival and proliferation. In our previous studies, we found that in addition to SRE, CRE is required for maximal c-fos promoter activation triggered by lysophosphatidic acid (LPA). c-fos is an early indicator of various cells into the cell cycle after mitogenic stimulation. However, role of CREB activation in LPA-stimulated proliferation has not been elucidated yet. Here, we investigate how LPA induces proliferation in Rat-2 fibroblast cell via CREB activation. We found that total cell number and BrdU-positive cells were increased by LPA. Moreover, levels of c-fos mRNA and cyclin D1 protein were increased via LPA-induced CREB phosphorylation. Furthermore, LPA-induced Rat-2 cell proliferation was decreased markedly by ERK inhibitor (U0126) and partially by MSK inhibitor (H89). Taken together, these results suggest that CREB activation could partially up-regulate accumulation of cyclin D1 protein level and proliferation of LPA-stimulated Rat-2 fibroblast cells." @default.
• W2119248051 created "2016-06-24" @default.
• W2119248051 creator A5025597932 @default.
• W2119248051 creator A5030359357 @default.
• W2119248051 creator A5062724561 @default.
• W2119248051 creator A5088876385 @default.
• W2119248051 date "2009-03-01" @default.
• W2119248051 modified "2023-09-26" @default.
• W2119248051 title "Phosphorylation of CREB, a cyclic AMP responsive element binding protein, contributes partially to lysophosphatidic acid-induced fibroblast cell proliferation" @default.
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• W2119248051 doi "https://doi.org/10.1016/j.bbrc.2009.01.159" @default.
• W2119248051 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/19285017" @default.
• W2119248051 hasPublicationYear "2009" @default.
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