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- W2119249181 abstract "<h3>Importance</h3> IgG4-related disease, which is newly recognized, is characterized by lymphoplasmacytic infiltration with increased IgG4-secreting plasma cells. Although a favorable response to steroids has previously been reported, the durations of follow-up to confirm the long-term benefits and clinical courses were limited. We describe long-term favorable response of oral methotrexate in a patient with IgG4-related pachymeningitis who was resistant to steroid therapy. <h3>Observations</h3> A patient in his mid-60s with pathologically proven IgG4-related pachymeningitis who was resistant to steroid therapy and experienced an exacerbation of symptoms 4 times is described. Low-dose oral methotrexate induced significant clinical and radiological improvement, with sustained remission of the disease over 2 years without complications. <h3>Conclusions and Relevance</h3> The long-term favorable response to oral methotrexate in the current patient suggests that methotrexate is a useful alternative treatment option in patients with IgG4-related pachymeningitis who are resistant to steroid therapy or who experience adverse effects from steroids." @default.
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- W2119249181 date "2014-02-01" @default.
- W2119249181 modified "2023-10-16" @default.
- W2119249181 title "Steroid-Resistant Relapsing IgG4-Related Pachymeningitis Treated With Methotrexate" @default.
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- W2119249181 doi "https://doi.org/10.1001/jamaneurol.2013.3950" @default.
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