FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2119252648> ?p ?o ?g. }

• W2119252648 endingPage "H1117" @default.
• W2119252648 startingPage "H1109" @default.
• W2119252648 abstract "The production of 20-hydroxyeicosatetraenoic acid (20-HETE) is increased during ischemia-reperfusion, and inhibition of 20-HETE production has been shown to reduce infarct size caused by ischemia. This study was aimed to discover the molecular mechanism underlying the action of 20-HETE in cardiac myocytes. The effect of 20-HETE on L-type Ca 2+ currents ( I Ca,L ) was examined in rat isolated cardiomyocytes by patch-clamp recording in the whole cell mode. Superfusion of cardiomyocytes with 20-HETE (10–100 nM) resulted in a concentration-dependent increase in I Ca,L , and this action of 20-HETE was attenuated by a specific NADPH oxidase inhibitor, gp91ds-tat (5 μM), or a superoxide scavenger, polyethylene glycol-superoxide dismutase (25 U/ml), suggesting that NADPH-oxidase-derived superoxide is involved in the stimulatory action of 20-HETE on I Ca,L . Treatment of cardiomyocytes with 20-HETE (100 nM) increased both NADPH oxidase activity and superoxide production by approximately twofold. To study the molecular mechanism mediating the 20-HETE-induced increase in NADPH oxidase activity, PKC activity was measured in cardiomyocytes. Incubation of the cells with 20-HETE (100 nM) significantly increased PKC activity, and pretreatment of cardiomyocytes with a selective PKC inhibitor, GF-109203 (1 μM), attenuated the 20-HETE-induced increases in I Ca,L and in NADPH oxidase activity. In summary, 20-HETE stimulates NADPH oxidase-derived superoxide production, which activates L-type Ca 2+ channels via a PKC-dependent mechanism in cardiomyocytes. 20-HETE and 20-HETE-producing enzymes could be novel targets for the treatment of cardiac ischemic diseases." @default.
• W2119252648 created "2016-06-24" @default.
• W2119252648 creator A5008684466 @default.
• W2119252648 creator A5017147831 @default.
• W2119252648 creator A5020741809 @default.
• W2119252648 creator A5024393450 @default.
• W2119252648 creator A5047397003 @default.
• W2119252648 creator A5053626139 @default.
• W2119252648 creator A5056101043 @default.
• W2119252648 creator A5058730856 @default.
• W2119252648 creator A5085892340 @default.
• W2119252648 creator A5087490613 @default.
• W2119252648 date "2010-10-01" @default.
• W2119252648 modified "2023-10-18" @default.
• W2119252648 title "20-HETE increases NADPH oxidase-derived ROS production and stimulates the L-type Ca²⁺ channel via a PKC-dependent mechanism in cardiomyocytes" @default.
• W2119252648 cites W161395021 @default.
• W2119252648 cites W1913730804 @default.
• W2119252648 cites W1969197079 @default.
• W2119252648 cites W1975569510 @default.
• W2119252648 cites W1976480176 @default.
• W2119252648 cites W1983820161 @default.
• W2119252648 cites W2017197026 @default.
• W2119252648 cites W2036674039 @default.
• W2119252648 cites W2036937904 @default.
• W2119252648 cites W2040815828 @default.
• W2119252648 cites W2050771112 @default.
• W2119252648 cites W2055793723 @default.
• W2119252648 cites W2061344850 @default.
• W2119252648 cites W2068939461 @default.
• W2119252648 cites W2076877595 @default.
• W2119252648 cites W2083065269 @default.
• W2119252648 cites W2086359022 @default.
• W2119252648 cites W2089630643 @default.
• W2119252648 cites W2108177961 @default.
• W2119252648 cites W2109686719 @default.
• W2119252648 cites W2117955834 @default.
• W2119252648 cites W2133344910 @default.
• W2119252648 cites W2143855170 @default.
• W2119252648 cites W2145558701 @default.
• W2119252648 cites W2148153039 @default.
• W2119252648 cites W2148525491 @default.
• W2119252648 cites W2149413938 @default.
• W2119252648 cites W2167117857 @default.
• W2119252648 cites W2168353728 @default.
• W2119252648 cites W4253456995 @default.
• W2119252648 cites W4253911545 @default.
• W2119252648 doi "https://doi.org/10.1152/ajpheart.00067.2010" @default.
• W2119252648 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2957347" @default.
• W2119252648 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/20675568" @default.
• W2119252648 hasPublicationYear "2010" @default.
• W2119252648 type Work @default.
• W2119252648 sameAs 2119252648 @default.
• W2119252648 citedByCount "52" @default.
• W2119252648 countsByYear W21192526482012 @default.
• W2119252648 countsByYear W21192526482013 @default.
• W2119252648 countsByYear W21192526482014 @default.
• W2119252648 countsByYear W21192526482015 @default.
• W2119252648 countsByYear W21192526482016 @default.
• W2119252648 countsByYear W21192526482017 @default.
• W2119252648 countsByYear W21192526482018 @default.
• W2119252648 countsByYear W21192526482019 @default.
• W2119252648 countsByYear W21192526482020 @default.
• W2119252648 countsByYear W21192526482021 @default.
• W2119252648 countsByYear W21192526482022 @default.
• W2119252648 countsByYear W21192526482023 @default.
• W2119252648 crossrefType "journal-article" @default.
• W2119252648 hasAuthorship W2119252648A5008684466 @default.
• W2119252648 hasAuthorship W2119252648A5017147831 @default.
• W2119252648 hasAuthorship W2119252648A5020741809 @default.
• W2119252648 hasAuthorship W2119252648A5024393450 @default.
• W2119252648 hasAuthorship W2119252648A5047397003 @default.
• W2119252648 hasAuthorship W2119252648A5053626139 @default.
• W2119252648 hasAuthorship W2119252648A5056101043 @default.
• W2119252648 hasAuthorship W2119252648A5058730856 @default.
• W2119252648 hasAuthorship W2119252648A5085892340 @default.
• W2119252648 hasAuthorship W2119252648A5087490613 @default.
• W2119252648 hasBestOaLocation W21192526482 @default.
• W2119252648 hasConcept C134018914 @default.
• W2119252648 hasConcept C181199279 @default.
• W2119252648 hasConcept C185592680 @default.
• W2119252648 hasConcept C195794163 @default.
• W2119252648 hasConcept C202751555 @default.
• W2119252648 hasConcept C207200792 @default.
• W2119252648 hasConcept C2775838275 @default.
• W2119252648 hasConcept C2776120743 @default.
• W2119252648 hasConcept C2776151105 @default.
• W2119252648 hasConcept C2779719074 @default.
• W2119252648 hasConcept C2780795997 @default.
• W2119252648 hasConcept C38485361 @default.
• W2119252648 hasConcept C48349386 @default.
• W2119252648 hasConcept C55493867 @default.
• W2119252648 hasConcept C86803240 @default.
• W2119252648 hasConceptScore W2119252648C134018914 @default.
• W2119252648 hasConceptScore W2119252648C181199279 @default.
• W2119252648 hasConceptScore W2119252648C185592680 @default.
• W2119252648 hasConceptScore W2119252648C195794163 @default.
• W2119252648 hasConceptScore W2119252648C202751555 @default.
• W2119252648 hasConceptScore W2119252648C207200792 @default.

• next