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• W2119273485 abstract "Substantial evidence indicate that growth factors such as platelet-derived growth factor (PDGF) exert their effect, at least in part, through reactive oxygen species (ROS) generated via NAD(P)H oxidase. In this work, the role of p47phox, a key component of the phagocytic NAD(P)H oxidase in cell proliferation, was addressed. The authors show that diphenylene iodonium (DPI) and apocynin, but not NG-nitro-L-arginine methyl esterL-NAME, reduced PDGF-induced ROS generation and proliferation in human umbilical vein endothelial cells (HUVECs). Pharmacological inhibition of protein kinase C (PKC) as well as dominant-negative mutants of p47phox directed to PKC-dependent phosphorylation targets inhibited PDGF-stimulated ROS production and cell proliferation. Hydrogen peroxide restored PDGF-stimulated proliferation in cells that was inhibited by apocynin, DPI, or by the dominant-negative mutants. PDGF-induced proliferation was reduced in the HUVEC-derived cell line E.A.hy926 overexpressing catalase. On the contrary, cells overexpressing superoxide dismutase 1 exhibited increased proliferation. These results demonstrate that PKC-dependent phosphorylation of p47phox is essential for PDGF-stimulated ROS generation and proliferation in HUVECs. More relevant, H2O2 is identified as the key molecule that signals proliferation in the systems studied." @default.
• W2119273485 created "2016-06-24" @default.
• W2119273485 creator A5050873414 @default.
• W2119273485 creator A5089650406 @default.
• W2119273485 date "2008-01-01" @default.
• W2119273485 modified "2023-10-16" @default.
• W2119273485 title "Protein Kinase C–Mediated Phosphorylation of p47^<b>phox</b>Modulates Platelet-Derived Growth Factor–Induced H_<b>2</b>O_<b>2</b>Generation and Cell Proliferation in Human Umbilical Vein Endothelial Cells" @default.
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• W2119273485 doi "https://doi.org/10.1080/10623320802174480" @default.
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• W2119273485 hasPublicationYear "2008" @default.
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