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- W2119275238 abstract "Angina pectoris resulting from myocardial ischemia afflicts half of all patients with coronary heart disease (CHD). Chronic angina remains a major public health burden despite state-of-the-art therapies, and improvement in survival from myocardial infarction and CHD has only increased its prevalence. There is growing experimental and clinical evidence pointing to the anti-ischemic and anti-anginal properties of statins. Some data suggest that the degree of anti-ischemic efficacy of statins may be comparable to the current standard pharmacologic and mechanical strategies. The pleiotropic effects of statins are postulated to be primarily responsible for their anti-ischemic and anti-anginal properties. These include improvement of endothelial function, enhancement of the ischemic vasodilatory response, modulation of inflammation, and protection from ischemia-reperfusion injury. The anti-ischemic effects of statins further strengthen their role as a crucial component of the optimal medical therapy for CHD." @default.
- W2119275238 created "2016-06-24" @default.
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- W2119275238 date "2010-11-24" @default.
- W2119275238 modified "2023-09-26" @default.
- W2119275238 title "The Anti-Ischemic and Anti-Anginal Properties of Statins" @default.
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- W2119275238 doi "https://doi.org/10.1007/s11883-010-0147-y" @default.
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