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• W2119279523 abstract "The CDC37 gene is essential for the activity of p60 v-src when expressed in yeast cells. Since the activation pathway for p60 v-src and steroid hormone receptors is similar, the present study analyzed the hormone-dependent transactivation by androgen receptors and glucocorticoid receptors in yeast cells expressing a mutant version of the CDC37gene. In this mutant, hormone-dependent transactivation by androgen receptors was defective at both permissive and restrictive temperatures, although transactivation by glucocorticoid receptors was mildly defective only at the restrictive temperature. Cdc37p appears to function via the androgen receptor ligand-binding domain, although it does not influence receptor hormone-binding affinity. Models for Cdc37p regulation of steroid hormone receptors are discussed." @default.
• W2119279523 created "2016-06-24" @default.
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• W2119279523 date "1997-12-01" @default.
• W2119279523 modified "2023-10-14" @default.
• W2119279523 title "Differential In Vivo Regulation of Steroid Hormone Receptor Activation by Cdc37p" @default.
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• W2119279523 doi "https://doi.org/10.1091/mbc.8.12.2501" @default.
• W2119279523 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/25723" @default.
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