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- W2119281301 abstract "We investigated the antileukemia effects and molecular mechanisms of apoptosis induction by simultaneous blockade of PI3K and mutant FLT3 in AML cells grown under hypoxia in co-cultures with bone marrow stromal cells. Combined treatment with selective class I PI3K inhibitor GDC-0941 and sorafenib reversed the protective effects of bone marrow stromal cells on FLT3-mutant AML cells in hypoxia, which was associated with downregulation of Pim-1 and Mcl-1 expression levels. These findings suggest that combined inhibition of PI3K and FLT3-ITD may constitute a targeted approach to eradicating chemoresistant AML cells sequestered in hypoxic bone marrow niches." @default.
- W2119281301 created "2016-06-24" @default.
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- W2119281301 date "2013-02-01" @default.
- W2119281301 modified "2023-09-30" @default.
- W2119281301 title "Mechanisms of apoptosis induction by simultaneous inhibition of PI3K and FLT3-ITD in AML cells in the hypoxic bone marrow microenvironment" @default.
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- W2119281301 doi "https://doi.org/10.1016/j.canlet.2012.09.020" @default.
- W2119281301 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3572533" @default.
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