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• W2119291330 endingPage "520" @default.
• W2119291330 startingPage "509" @default.
• W2119291330 abstract "Stem cells are classically defined by their multipotent, long-term proliferation, and self-renewal capabilities. Here, we show that increased antioxidant capacity represents an additional functional characteristic of muscle-derived stem cells (MDSCs). Seeking to understand the superior regenerative capacity of MDSCs compared with myoblasts in cardiac and skeletal muscle transplantation, our group hypothesized that survival of the oxidative and inflammatory stress inherent to transplantation may play an important role. Evidence of increased enzymatic and nonenzymatic antioxidant capacity of MDSCs were observed in terms of higher levels of superoxide dismutase and glutathione, which appears to confer a differentiation and survival advantage. Further when glutathione levels of the MDSCs are lowered to that of myoblasts, the transplantation advantage of MDSCs over myoblasts is lost when transplanted into both skeletal and cardiac muscles. These findings elucidate an important cause for the superior regenerative capacity of MDSCs, and provide functional evidence for the emerging role of antioxidant capacity as a critical property for MDSC survival post-transplantation." @default.
• W2119291330 created "2016-06-24" @default.
• W2119291330 creator A5002448467 @default.
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• W2119291330 creator A5079296516 @default.
• W2119291330 creator A5084220653 @default.
• W2119291330 date "2009-01-01" @default.
• W2119291330 modified "2023-09-23" @default.
• W2119291330 title "Antioxidant Levels Represent a Major Determinant in the Regenerative Capacity of Muscle Stem Cells" @default.
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• W2119291330 doi "https://doi.org/10.1091/mbc.e08-03-0274" @default.
• W2119291330 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2613087" @default.
• W2119291330 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/19005220" @default.
• W2119291330 hasPublicationYear "2009" @default.
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