FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2119341715> ?p ?o ?g. }

• W2119341715 endingPage "939" @default.
• W2119341715 startingPage "934" @default.
• W2119341715 abstract "Zomepirac is a nonsteroidal anti-inflammatory drug recently withdrawn from use because of an unexplained high incidence of immunological reactions. It is metabolized in humans to a reactive, unstable acyl glucuronide which accumulates in plasma. Because of the similarity of zomepirac glucuronide to bilirubin glucuronide in structure and stability and the documented irreversible binding of bilirubin to albumin through its acyl glucuronide, we studied the reaction of zomepirac acyl glucuronide with albumin in vitro from pH 5 to 9 and in vivo in six healthy human volunteers who had received a single 100-mg oral dose of zomepirac. Irreversible binding of zomepirac to protein was determined by exhaustive washing of protein, followed by hydrolysis of bound zomepirac-protein adduct with base, extraction of the liberated drug, and chromatographic measurement. Irreversible binding was observed both in vitro and in vivo. The extent of binding in vitro was time- and pH-dependent. In vitro drug binding was also observed for the isomers of zomepirac glucuronide which were formed by intramolecular acyl migration. Irreversible binding in vivo correlated with overall exposure to zomepirac glucuronide when exposure was expressed as the area under the plasma concentration vs. time curve. When probenecid (500 mg, twice daily), which decreases the plasma clearance of zomepirac glucuronide, was administered concurrently with zomepirac, irreversible binding of zomepirac was increased. The nature of the zomepirac protein binding is probably covalent. Formation of irreversibly protein-bound zomepirac occurs via the acyl glucuronide as previously shown for bilirubin glucuronide, and the reaction may be general for other drugs that are metabolized to acyl glucuronides." @default.
• W2119341715 created "2016-06-24" @default.
• W2119341715 creator A5015647281 @default.
• W2119341715 creator A5059292691 @default.
• W2119341715 creator A5075960682 @default.
• W2119341715 date "1986-03-01" @default.
• W2119341715 modified "2023-10-16" @default.
• W2119341715 title "Irreversible binding of zomepirac to plasma protein in vitro and in vivo." @default.
• W2119341715 cites W1233819292 @default.
• W2119341715 cites W1490909565 @default.
• W2119341715 cites W1575563617 @default.
• W2119341715 cites W1577347418 @default.
• W2119341715 cites W1582388915 @default.
• W2119341715 cites W1844237400 @default.
• W2119341715 cites W1860244422 @default.
• W2119341715 cites W1942189383 @default.
• W2119341715 cites W1955458585 @default.
• W2119341715 cites W1971077247 @default.
• W2119341715 cites W1976060163 @default.
• W2119341715 cites W2009028662 @default.
• W2119341715 cites W2013883554 @default.
• W2119341715 cites W2019908786 @default.
• W2119341715 cites W2036915173 @default.
• W2119341715 cites W2057719285 @default.
• W2119341715 cites W2063056012 @default.
• W2119341715 cites W2073620575 @default.
• W2119341715 cites W2094754630 @default.
• W2119341715 cites W2138902203 @default.
• W2119341715 cites W2316573024 @default.
• W2119341715 cites W2440050728 @default.
• W2119341715 cites W2468393708 @default.
• W2119341715 doi "https://doi.org/10.1172/jci112392" @default.
• W2119341715 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/423485" @default.
• W2119341715 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/3949982" @default.
• W2119341715 hasPublicationYear "1986" @default.
• W2119341715 type Work @default.
• W2119341715 sameAs 2119341715 @default.
• W2119341715 citedByCount "154" @default.
• W2119341715 countsByYear W21193417152012 @default.
• W2119341715 countsByYear W21193417152013 @default.
• W2119341715 countsByYear W21193417152014 @default.
• W2119341715 countsByYear W21193417152015 @default.
• W2119341715 countsByYear W21193417152016 @default.
• W2119341715 countsByYear W21193417152017 @default.
• W2119341715 countsByYear W21193417152019 @default.
• W2119341715 countsByYear W21193417152022 @default.
• W2119341715 countsByYear W21193417152023 @default.
• W2119341715 crossrefType "journal-article" @default.
• W2119341715 hasAuthorship W2119341715A5015647281 @default.
• W2119341715 hasAuthorship W2119341715A5059292691 @default.
• W2119341715 hasAuthorship W2119341715A5075960682 @default.
• W2119341715 hasBestOaLocation W21193417151 @default.
• W2119341715 hasConcept C126322002 @default.
• W2119341715 hasConcept C146543888 @default.
• W2119341715 hasConcept C150903083 @default.
• W2119341715 hasConcept C165616093 @default.
• W2119341715 hasConcept C185592680 @default.
• W2119341715 hasConcept C202751555 @default.
• W2119341715 hasConcept C207001950 @default.
• W2119341715 hasConcept C2776125364 @default.
• W2119341715 hasConcept C2777477808 @default.
• W2119341715 hasConcept C2777513400 @default.
• W2119341715 hasConcept C2778597219 @default.
• W2119341715 hasConcept C2779186261 @default.
• W2119341715 hasConcept C51639874 @default.
• W2119341715 hasConcept C55493867 @default.
• W2119341715 hasConcept C71924100 @default.
• W2119341715 hasConcept C86803240 @default.
• W2119341715 hasConceptScore W2119341715C126322002 @default.
• W2119341715 hasConceptScore W2119341715C146543888 @default.
• W2119341715 hasConceptScore W2119341715C150903083 @default.
• W2119341715 hasConceptScore W2119341715C165616093 @default.
• W2119341715 hasConceptScore W2119341715C185592680 @default.
• W2119341715 hasConceptScore W2119341715C202751555 @default.
• W2119341715 hasConceptScore W2119341715C207001950 @default.
• W2119341715 hasConceptScore W2119341715C2776125364 @default.
• W2119341715 hasConceptScore W2119341715C2777477808 @default.
• W2119341715 hasConceptScore W2119341715C2777513400 @default.
• W2119341715 hasConceptScore W2119341715C2778597219 @default.
• W2119341715 hasConceptScore W2119341715C2779186261 @default.
• W2119341715 hasConceptScore W2119341715C51639874 @default.
• W2119341715 hasConceptScore W2119341715C55493867 @default.
• W2119341715 hasConceptScore W2119341715C71924100 @default.
• W2119341715 hasConceptScore W2119341715C86803240 @default.
• W2119341715 hasIssue "3" @default.
• W2119341715 hasLocation W21193417151 @default.
• W2119341715 hasLocation W21193417152 @default.
• W2119341715 hasLocation W21193417153 @default.
• W2119341715 hasLocation W21193417154 @default.
• W2119341715 hasOpenAccess W2119341715 @default.
• W2119341715 hasPrimaryLocation W21193417151 @default.
• W2119341715 hasRelatedWork W1989672218 @default.
• W2119341715 hasRelatedWork W2024017193 @default.
• W2119341715 hasRelatedWork W2062528380 @default.
• W2119341715 hasRelatedWork W2092053794 @default.
• W2119341715 hasRelatedWork W2329697220 @default.
• W2119341715 hasRelatedWork W2408568198 @default.
• W2119341715 hasRelatedWork W2414398362 @default.

• next