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• W2119344181 endingPage "2155" @default.
• W2119344181 startingPage "2145" @default.
• W2119344181 abstract "We have used the ciliate Euplotes to study the role of DNA polymerase in telomeric C strand synthesis. Euplotes provides a unique opportunity to study C strand synthesis without the complication of simultaneous DNA replication because millions of new telomeres are made at a stage in the life cycle when no general DNA replication takes place. Previously we showed that the C-strands of newly synthesized telomeres have a precisely controlled length while the G-strands are more heterogeneous. This finding suggested that, although synthesis of the G-strand (by telomerase) is the first step in telomere addition, a major regulatory step occurs during subsequent C strand synthesis. We have now examined whether G- and C strand synthesis might be regulated coordinately rather than by two independent mechanisms. We accomplished this by determining what happens to G- and C strand length if C strand synthesis is partially inhibited by aphidicolin. Aphidicolin treatment caused a general lengthening of the G-strands and a large increase in C strand heterogeneity. This concomitant change in both the G- and C strand length indicates that synthesis of the two strands is coordinated. Since aphidicolin is a very specific inhibitor of DNA pol alpha and pol delta, our results suggest that this coordinate length regulation is mediated by DNA polymerase." @default.
• W2119344181 created "2016-06-24" @default.
• W2119344181 creator A5029702728 @default.
• W2119344181 creator A5044181861 @default.
• W2119344181 date "1997-11-01" @default.
• W2119344181 modified "2023-09-25" @default.
• W2119344181 title "Coordinate Regulation of G- and C Strand Length during New Telomere Synthesis" @default.
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• W2119344181 doi "https://doi.org/10.1091/mbc.8.11.2145" @default.
• W2119344181 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/25698" @default.
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