FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2119367007> ?p ?o ?g. }

• W2119367007 endingPage "e12305" @default.
• W2119367007 startingPage "e12305" @default.
• W2119367007 abstract "Autosomal Dominant Polycystic Kidney Disease (ADPKD) is a genetic disorder resulting in large kidney cysts and eventual kidney failure. Mutations in either the PKD1 or PKD2/TRPP2 genes and their respective protein products, polycystin-1 (PC1) and polycystin-2 (PC2) result in ADPKD. PC2 is known to function as a non-selective cation channel, but PC1's function and the function of PC1 cleavage products are not well understood. Here we identify an endogenous PC1 cleavage product, P100, a 100 kDa fragment found in both wild type and epitope tagged PKD1 knock-in mice. Expression of full length human PC1 (FL PC1) and the resulting P100 and C-Terminal Fragment (CTF) cleavage products in both MDCK and CHO cells significantly reduces the store operated Ca2+ entry (SOCE) resulting from thapsigargin induced store depletion. Exploration into the roles of P100 and CTF in SOCE inhibition reveal that P100, when expressed in Xenopus laevis oocytes, directly inhibits the SOCE currents but CTF does not, nor does P100 when containing the disease causing R4227X mutation. Interestingly, we also found that in PC1 expressing MDCK cells, translocation of the ER Ca2+ sensor protein STIM1 to the cell periphery was significantly altered. In addition, P100 Co-immunoprecipitates with STIM1 but CTF does not. The expression of P100 in CHO cells recapitulates the STIM1 translocation inhibition seen with FL PC1. These data describe a novel polycystin-1 cleavage product, P100, which functions to reduce SOCE via direct inhibition of STIM1 translocation; a function with consequences for ADPKD." @default.
• W2119367007 created "2016-06-24" @default.
• W2119367007 creator A5003067418 @default.
• W2119367007 creator A5027931606 @default.
• W2119367007 creator A5029220053 @default.
• W2119367007 creator A5032020402 @default.
• W2119367007 creator A5032526310 @default.
• W2119367007 creator A5036786138 @default.
• W2119367007 creator A5080710980 @default.
• W2119367007 creator A5086600941 @default.
• W2119367007 date "2010-08-23" @default.
• W2119367007 modified "2023-09-26" @default.
• W2119367007 title "Identification of a Polycystin-1 Cleavage Product, P100, That Regulates Store Operated Ca2+ Entry through Interactions with STIM1" @default.
• W2119367007 cites W1492104840 @default.
• W2119367007 cites W1607531254 @default.
• W2119367007 cites W1988523658 @default.
• W2119367007 cites W1991947898 @default.
• W2119367007 cites W2002218554 @default.
• W2119367007 cites W2005026678 @default.
• W2119367007 cites W2013002334 @default.
• W2119367007 cites W2013681980 @default.
• W2119367007 cites W2018547785 @default.
• W2119367007 cites W2019023589 @default.
• W2119367007 cites W2020708758 @default.
• W2119367007 cites W2025221100 @default.
• W2119367007 cites W2041474455 @default.
• W2119367007 cites W2047052174 @default.
• W2119367007 cites W2048162979 @default.
• W2119367007 cites W2050780119 @default.
• W2119367007 cites W2057111142 @default.
• W2119367007 cites W2063191450 @default.
• W2119367007 cites W2068571139 @default.
• W2119367007 cites W2068642486 @default.
• W2119367007 cites W2070988383 @default.
• W2119367007 cites W2071001965 @default.
• W2119367007 cites W2075777351 @default.
• W2119367007 cites W2095869636 @default.
• W2119367007 cites W2097214606 @default.
• W2119367007 cites W2110248507 @default.
• W2119367007 cites W2112900504 @default.
• W2119367007 cites W2120146971 @default.
• W2119367007 cites W2120487258 @default.
• W2119367007 cites W2126535828 @default.
• W2119367007 cites W2130610065 @default.
• W2119367007 cites W2133603157 @default.
• W2119367007 cites W2135589742 @default.
• W2119367007 cites W2138061240 @default.
• W2119367007 cites W2150136880 @default.
• W2119367007 cites W2153155610 @default.
• W2119367007 cites W2153360576 @default.
• W2119367007 cites W2154643490 @default.
• W2119367007 cites W2158652398 @default.
• W2119367007 cites W2164612151 @default.
• W2119367007 doi "https://doi.org/10.1371/journal.pone.0012305" @default.
• W2119367007 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2925899" @default.
• W2119367007 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/20808796" @default.
• W2119367007 hasPublicationYear "2010" @default.
• W2119367007 type Work @default.
• W2119367007 sameAs 2119367007 @default.
• W2119367007 citedByCount "64" @default.
• W2119367007 countsByYear W21193670072012 @default.
• W2119367007 countsByYear W21193670072013 @default.
• W2119367007 countsByYear W21193670072014 @default.
• W2119367007 countsByYear W21193670072015 @default.
• W2119367007 countsByYear W21193670072016 @default.
• W2119367007 countsByYear W21193670072017 @default.
• W2119367007 countsByYear W21193670072018 @default.
• W2119367007 countsByYear W21193670072019 @default.
• W2119367007 countsByYear W21193670072020 @default.
• W2119367007 countsByYear W21193670072021 @default.
• W2119367007 countsByYear W21193670072022 @default.
• W2119367007 countsByYear W21193670072023 @default.
• W2119367007 crossrefType "journal-article" @default.
• W2119367007 hasAuthorship W2119367007A5003067418 @default.
• W2119367007 hasAuthorship W2119367007A5027931606 @default.
• W2119367007 hasAuthorship W2119367007A5029220053 @default.
• W2119367007 hasAuthorship W2119367007A5032020402 @default.
• W2119367007 hasAuthorship W2119367007A5032526310 @default.
• W2119367007 hasAuthorship W2119367007A5036786138 @default.
• W2119367007 hasAuthorship W2119367007A5080710980 @default.
• W2119367007 hasAuthorship W2119367007A5086600941 @default.
• W2119367007 hasBestOaLocation W21193670071 @default.
• W2119367007 hasConcept C100773827 @default.
• W2119367007 hasConcept C104317684 @default.
• W2119367007 hasConcept C150194340 @default.
• W2119367007 hasConcept C151730666 @default.
• W2119367007 hasConcept C153911025 @default.
• W2119367007 hasConcept C158617107 @default.
• W2119367007 hasConcept C162740809 @default.
• W2119367007 hasConcept C174510640 @default.
• W2119367007 hasConcept C175156509 @default.
• W2119367007 hasConcept C185592680 @default.
• W2119367007 hasConcept C195286587 @default.
• W2119367007 hasConcept C2776266639 @default.
• W2119367007 hasConcept C2776610495 @default.
• W2119367007 hasConcept C2777146706 @default.
• W2119367007 hasConcept C2779535977 @default.
• W2119367007 hasConcept C2780091579 @default.

• next