FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2119377931> ?p ?o ?g. }

• W2119377931 endingPage "813" @default.
• W2119377931 startingPage "806" @default.
• W2119377931 abstract "The human <i>ether-à-go-go</i>-related gene (hERG) encodes the pore-forming subunit of the rapidly activating delayed rectifier K⁺ current (<i>I</i>_Kr) important for cardiac repolarization. Dysfunction of the hERG channel causes long QT syndrome (LQTS). Although diverse compounds reduce the hERG current (<i>I</i>_hERG) by blocking the channel, probucol, a cholesterol-lowering drug that causes LQTS, reduces <i>I</i>_hERG by decreasing plasma-membrane hERG protein expression. Here, we investigated the mechanisms of probucol effects on hERG expression levels. Our data demonstrate that probucol accelerated the degradation of mature hERG channels, which associated with caveolin-1 (Cav1) in hERG-expressing HEK cells. In human embryonic kidney (HEK) cells without hERG expression, probucol promoted endogenous Cav1 degradation. In hERG-expressing HEK cells, overexpression of Cav1 enhanced, whereas knockdown of Cav1 impeded, probucol-induced reduction of mature hERG channels. Thus, probucol reduces hERG expression through accelerating Cav1 turnover. The effects of probucol on Cav1 and hERG result from probucol9s cholesterol-disrupting action, because low-density lipoprotein (LDL), a potent cholesterol carrier, effectively prevented probucol-induced reduction of <i>I</i>_hERG in hERG-expressing HEK cells and of <i>I</i>_Kr in neonatal rat cardiomyocytes. Our data provide evidence that targeting hERG-interacting protein caveolin represents a novel mechanism for drugs to decrease hERG expression and cause LQTS." @default.
• W2119377931 created "2016-06-24" @default.
• W2119377931 creator A5010145003 @default.
• W2119377931 creator A5011343099 @default.
• W2119377931 creator A5017379979 @default.
• W2119377931 creator A5023141434 @default.
• W2119377931 creator A5050508643 @default.
• W2119377931 creator A5061837237 @default.
• W2119377931 creator A5063382606 @default.
• W2119377931 creator A5069550460 @default.
• W2119377931 creator A5069846650 @default.
• W2119377931 creator A5083617730 @default.
• W2119377931 date "2011-01-28" @default.
• W2119377931 modified "2023-10-03" @default.
• W2119377931 title "Involvement of Caveolin in Probucol-Induced Reduction in hERG Plasma-Membrane Expression" @default.
• W2119377931 cites W1533747850 @default.
• W2119377931 cites W1564861448 @default.
• W2119377931 cites W1963869388 @default.
• W2119377931 cites W1968098810 @default.
• W2119377931 cites W1981088394 @default.
• W2119377931 cites W1989163072 @default.
• W2119377931 cites W2003676394 @default.
• W2119377931 cites W2003688961 @default.
• W2119377931 cites W2005303514 @default.
• W2119377931 cites W2009667219 @default.
• W2119377931 cites W2013229808 @default.
• W2119377931 cites W2021438486 @default.
• W2119377931 cites W2036988497 @default.
• W2119377931 cites W2040826404 @default.
• W2119377931 cites W2045610340 @default.
• W2119377931 cites W2052976216 @default.
• W2119377931 cites W2062315382 @default.
• W2119377931 cites W2065771385 @default.
• W2119377931 cites W2066291092 @default.
• W2119377931 cites W2069444054 @default.
• W2119377931 cites W2079521511 @default.
• W2119377931 cites W2085048839 @default.
• W2119377931 cites W2106383747 @default.
• W2119377931 cites W2108872041 @default.
• W2119377931 cites W2110581720 @default.
• W2119377931 cites W2111833940 @default.
• W2119377931 cites W2113089151 @default.
• W2119377931 cites W2117700932 @default.
• W2119377931 cites W2121936687 @default.
• W2119377931 cites W2122402164 @default.
• W2119377931 cites W2127942339 @default.
• W2119377931 cites W2131472696 @default.
• W2119377931 cites W2141367941 @default.
• W2119377931 cites W2148073507 @default.
• W2119377931 cites W2148302928 @default.
• W2119377931 cites W2153077614 @default.
• W2119377931 cites W2168590026 @default.
• W2119377931 cites W2185509072 @default.
• W2119377931 doi "https://doi.org/10.1124/mol.110.069419" @default.
• W2119377931 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/21278233" @default.
• W2119377931 hasPublicationYear "2011" @default.
• W2119377931 type Work @default.
• W2119377931 sameAs 2119377931 @default.
• W2119377931 citedByCount "42" @default.
• W2119377931 countsByYear W21193779312012 @default.
• W2119377931 countsByYear W21193779312013 @default.
• W2119377931 countsByYear W21193779312014 @default.
• W2119377931 countsByYear W21193779312015 @default.
• W2119377931 countsByYear W21193779312016 @default.
• W2119377931 countsByYear W21193779312017 @default.
• W2119377931 countsByYear W21193779312019 @default.
• W2119377931 countsByYear W21193779312020 @default.
• W2119377931 countsByYear W21193779312021 @default.
• W2119377931 countsByYear W21193779312022 @default.
• W2119377931 countsByYear W21193779312023 @default.
• W2119377931 crossrefType "journal-article" @default.
• W2119377931 hasAuthorship W2119377931A5010145003 @default.
• W2119377931 hasAuthorship W2119377931A5011343099 @default.
• W2119377931 hasAuthorship W2119377931A5017379979 @default.
• W2119377931 hasAuthorship W2119377931A5023141434 @default.
• W2119377931 hasAuthorship W2119377931A5050508643 @default.
• W2119377931 hasAuthorship W2119377931A5061837237 @default.
• W2119377931 hasAuthorship W2119377931A5063382606 @default.
• W2119377931 hasAuthorship W2119377931A5069550460 @default.
• W2119377931 hasAuthorship W2119377931A5069846650 @default.
• W2119377931 hasAuthorship W2119377931A5083617730 @default.
• W2119377931 hasConcept C118441451 @default.
• W2119377931 hasConcept C126322002 @default.
• W2119377931 hasConcept C170493617 @default.
• W2119377931 hasConcept C173396325 @default.
• W2119377931 hasConcept C174510640 @default.
• W2119377931 hasConcept C185592680 @default.
• W2119377931 hasConcept C190283241 @default.
• W2119377931 hasConcept C2776167589 @default.
• W2119377931 hasConcept C2778163477 @default.
• W2119377931 hasConcept C2779362680 @default.
• W2119377931 hasConcept C2779703243 @default.
• W2119377931 hasConcept C55493867 @default.
• W2119377931 hasConcept C71924100 @default.
• W2119377931 hasConcept C83743174 @default.
• W2119377931 hasConcept C86803240 @default.
• W2119377931 hasConcept C98274493 @default.
• W2119377931 hasConceptScore W2119377931C118441451 @default.

• next