FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2119384581> ?p ?o ?g. }

• W2119384581 endingPage "5237" @default.
• W2119384581 startingPage "5222" @default.
• W2119384581 abstract "The precise localization of D1 and D2 dopamine receptors within striatal neurons and circuits is crucial information for further understanding dopamine pharmacology. We have used subtype specific polyclonal and monoclonal antibodies against D1 and D2 dopamine receptors to determine their cellular and subcellular distributions, their colocalization, and their differential connectivity with motor cortical afferents labeled either by lesion-induced degeneration or by anterograde transport of biotinylated dextrans. D1 and D2 are primarily expressed in medium-sized neurons and spiny dendrites. Axon terminals containing D1 were rare whereas D2-immunoreactive axon terminals forming symmetrical synapses with dendrites and spines were common. In 2 microns sections, D1 was localized to 53% of neurons, and D2 to 48% of neurons, while mixing D1 and D2 antibodies labeled 78%. By electron microscopy, D1 was localized to 43% of dendrites and 38% of spines while D2 was localized to 38% of dendrites and 48% of spines. Combining D1 and D2 antibodies resulted in the labeling of 88.5% of dendrites and 92.6% of spines. Using different chromogens for D1 and D2, colocalization was not observed. Ipsilateral motor corticostriatal afferents were primarily axospinous and significantly more synapsed with D1 than D2-positive spines (65% vs 47%). Contralateral motor corticostriatal afferents were frequently axodendritic and no difference in their frequency of synapses with D1 and D2 dendrites and spines was observed. These findings demonstrate differential patterns of expression of D1 and D2 receptors in striatal neurons and axon terminals and their differential involvement in motor corticostriatal circuits." @default.
• W2119384581 created "2016-06-24" @default.
• W2119384581 creator A5004731575 @default.
• W2119384581 creator A5023920651 @default.
• W2119384581 creator A5032351341 @default.
• W2119384581 creator A5036399957 @default.
• W2119384581 creator A5037008515 @default.
• W2119384581 creator A5044906953 @default.
• W2119384581 creator A5051418301 @default.
• W2119384581 creator A5055898116 @default.
• W2119384581 creator A5060939637 @default.
• W2119384581 creator A5064303676 @default.
• W2119384581 date "1995-07-01" @default.
• W2119384581 modified "2023-10-18" @default.
• W2119384581 title "Electron microscopic analysis of D1 and D2 dopamine receptor proteins in the dorsal striatum and their synaptic relationships with motor corticostriatal afferents" @default.
• W2119384581 cites W1582882965 @default.
• W2119384581 cites W1612954914 @default.
• W2119384581 cites W1625996387 @default.
• W2119384581 cites W1856503606 @default.
• W2119384581 cites W1934062495 @default.
• W2119384581 cites W1964235419 @default.
• W2119384581 cites W1966385306 @default.
• W2119384581 cites W1969743652 @default.
• W2119384581 cites W1970374596 @default.
• W2119384581 cites W1974183957 @default.
• W2119384581 cites W1980921936 @default.
• W2119384581 cites W1983035864 @default.
• W2119384581 cites W1986478158 @default.
• W2119384581 cites W1991603311 @default.
• W2119384581 cites W1991913837 @default.
• W2119384581 cites W1996535168 @default.
• W2119384581 cites W1999130304 @default.
• W2119384581 cites W2001600462 @default.
• W2119384581 cites W2005235262 @default.
• W2119384581 cites W2014727433 @default.
• W2119384581 cites W2025170140 @default.
• W2119384581 cites W2026083165 @default.
• W2119384581 cites W2026306356 @default.
• W2119384581 cites W2028466783 @default.
• W2119384581 cites W2031422121 @default.
• W2119384581 cites W2031444503 @default.
• W2119384581 cites W2034539562 @default.
• W2119384581 cites W2036398765 @default.
• W2119384581 cites W2038054494 @default.
• W2119384581 cites W2038359785 @default.
• W2119384581 cites W2038991173 @default.
• W2119384581 cites W2039732315 @default.
• W2119384581 cites W2042369174 @default.
• W2119384581 cites W2045863504 @default.
• W2119384581 cites W2052566938 @default.
• W2119384581 cites W2053959292 @default.
• W2119384581 cites W2055681098 @default.
• W2119384581 cites W2056923358 @default.
• W2119384581 cites W2058703825 @default.
• W2119384581 cites W2065241932 @default.
• W2119384581 cites W2073325183 @default.
• W2119384581 cites W2076635082 @default.
• W2119384581 cites W2080914638 @default.
• W2119384581 cites W2087688448 @default.
• W2119384581 cites W2089924985 @default.
• W2119384581 cites W2091541450 @default.
• W2119384581 cites W2091547330 @default.
• W2119384581 cites W2094664644 @default.
• W2119384581 cites W2094886743 @default.
• W2119384581 cites W2101108802 @default.
• W2119384581 cites W2101473364 @default.
• W2119384581 cites W2104302486 @default.
• W2119384581 cites W2120008715 @default.
• W2119384581 cites W2145151967 @default.
• W2119384581 cites W2155599139 @default.
• W2119384581 cites W2157867342 @default.
• W2119384581 cites W2163815564 @default.
• W2119384581 cites W2300562612 @default.
• W2119384581 cites W2444051393 @default.
• W2119384581 cites W270624818 @default.
• W2119384581 cites W2884559245 @default.
• W2119384581 cites W2410390163 @default.
• W2119384581 doi "https://doi.org/10.1523/jneurosci.15-07-05222.1995" @default.
• W2119384581 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6577913" @default.
• W2119384581 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/7623147" @default.
• W2119384581 hasPublicationYear "1995" @default.
• W2119384581 type Work @default.
• W2119384581 sameAs 2119384581 @default.
• W2119384581 citedByCount "458" @default.
• W2119384581 countsByYear W21193845812012 @default.
• W2119384581 countsByYear W21193845812013 @default.
• W2119384581 countsByYear W21193845812014 @default.
• W2119384581 countsByYear W21193845812015 @default.
• W2119384581 countsByYear W21193845812016 @default.
• W2119384581 countsByYear W21193845812017 @default.
• W2119384581 countsByYear W21193845812018 @default.
• W2119384581 countsByYear W21193845812019 @default.
• W2119384581 countsByYear W21193845812020 @default.
• W2119384581 countsByYear W21193845812021 @default.
• W2119384581 countsByYear W21193845812022 @default.
• W2119384581 countsByYear W21193845812023 @default.
• W2119384581 crossrefType "journal-article" @default.
• W2119384581 hasAuthorship W2119384581A5004731575 @default.

• next