FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2119413295> ?p ?o ?g. }

• W2119413295 endingPage "34" @default.
• W2119413295 startingPage "34" @default.
• W2119413295 abstract "Loss of retinal ganglion cells (RGCs) is a hallmark of various retinal diseases including glaucoma, retinal ischemia, and diabetic retinopathy. N-methyl-D-aspartate (NMDA)-type glutamate receptor (NMDAR)-mediated excitotoxicity is thought to be an important contributor to RGC death in these diseases. Native NMDARs are heterotetramers that consist of GluN1 and GluN2 subunits, and GluN2 subunits (GluN2A-D) are major determinants of the pharmacological and biophysical properties of NMDARs. All NMDAR subunits are expressed in RGCs in the retina. However, the relative contribution of the different GluN2 subunits to RGC death by excitotoxicity remains unclear.GluN2B- and GluN2D-deficiency protected RGCs from NMDA-induced excitotoxic retinal cell death. Pharmacological inhibition of the GluN2B subunit attenuated RGC loss in glutamate aspartate transporter deficient mice.Our data suggest that GluN2B- and GluN2D-containing NMDARs play a critical role in NMDA-induced excitotoxic retinal cell death and RGC degeneration in glutamate aspartate transporter deficient mice. Inhibition of GluN2B and GluN2D activity is a potential therapeutic strategy for the treatment of several retinal diseases." @default.
• W2119413295 created "2016-06-24" @default.
• W2119413295 creator A5018186082 @default.
• W2119413295 creator A5034434808 @default.
• W2119413295 creator A5036030626 @default.
• W2119413295 creator A5038633165 @default.
• W2119413295 creator A5047849556 @default.
• W2119413295 creator A5048397528 @default.
• W2119413295 creator A5061509682 @default.
• W2119413295 date "2013-01-01" @default.
• W2119413295 modified "2023-09-23" @default.
• W2119413295 title "NMDA receptor subunits have different roles in NMDA-induced neurotoxicity in the retina" @default.
• W2119413295 cites W1966556202 @default.
• W2119413295 cites W1970929051 @default.
• W2119413295 cites W1973199799 @default.
• W2119413295 cites W1991720631 @default.
• W2119413295 cites W1994732950 @default.
• W2119413295 cites W1995061391 @default.
• W2119413295 cites W1995681441 @default.
• W2119413295 cites W2016575029 @default.
• W2119413295 cites W2025634687 @default.
• W2119413295 cites W2025669261 @default.
• W2119413295 cites W2034219417 @default.
• W2119413295 cites W2034738190 @default.
• W2119413295 cites W2036650593 @default.
• W2119413295 cites W2044818530 @default.
• W2119413295 cites W2044861937 @default.
• W2119413295 cites W2045562608 @default.
• W2119413295 cites W2056305593 @default.
• W2119413295 cites W2059710790 @default.
• W2119413295 cites W2060944001 @default.
• W2119413295 cites W2062051253 @default.
• W2119413295 cites W2064758852 @default.
• W2119413295 cites W2064951237 @default.
• W2119413295 cites W2068265875 @default.
• W2119413295 cites W2075205619 @default.
• W2119413295 cites W2086656695 @default.
• W2119413295 cites W2087310348 @default.
• W2119413295 cites W2088396961 @default.
• W2119413295 cites W2090923339 @default.
• W2119413295 cites W2097693778 @default.
• W2119413295 cites W2104135721 @default.
• W2119413295 cites W2116635659 @default.
• W2119413295 cites W2127810309 @default.
• W2119413295 cites W2128645913 @default.
• W2119413295 cites W2145273997 @default.
• W2119413295 cites W2153315387 @default.
• W2119413295 cites W2154582084 @default.
• W2119413295 cites W2168991961 @default.
• W2119413295 cites W2174668858 @default.
• W2119413295 doi "https://doi.org/10.1186/1756-6606-6-34" @default.
• W2119413295 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3733768" @default.
• W2119413295 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/23902942" @default.
• W2119413295 hasPublicationYear "2013" @default.
• W2119413295 type Work @default.
• W2119413295 sameAs 2119413295 @default.
• W2119413295 citedByCount "54" @default.
• W2119413295 countsByYear W21194132952013 @default.
• W2119413295 countsByYear W21194132952014 @default.
• W2119413295 countsByYear W21194132952015 @default.
• W2119413295 countsByYear W21194132952016 @default.
• W2119413295 countsByYear W21194132952017 @default.
• W2119413295 countsByYear W21194132952018 @default.
• W2119413295 countsByYear W21194132952019 @default.
• W2119413295 countsByYear W21194132952020 @default.
• W2119413295 countsByYear W21194132952021 @default.
• W2119413295 countsByYear W21194132952022 @default.
• W2119413295 countsByYear W21194132952023 @default.
• W2119413295 crossrefType "journal-article" @default.
• W2119413295 hasAuthorship W2119413295A5018186082 @default.
• W2119413295 hasAuthorship W2119413295A5034434808 @default.
• W2119413295 hasAuthorship W2119413295A5036030626 @default.
• W2119413295 hasAuthorship W2119413295A5038633165 @default.
• W2119413295 hasAuthorship W2119413295A5047849556 @default.
• W2119413295 hasAuthorship W2119413295A5048397528 @default.
• W2119413295 hasAuthorship W2119413295A5061509682 @default.
• W2119413295 hasBestOaLocation W21194132951 @default.
• W2119413295 hasConcept C169760540 @default.
• W2119413295 hasConcept C170493617 @default.
• W2119413295 hasConcept C185592680 @default.
• W2119413295 hasConcept C2777093970 @default.
• W2119413295 hasConcept C2777624874 @default.
• W2119413295 hasConcept C2779484449 @default.
• W2119413295 hasConcept C2780827179 @default.
• W2119413295 hasConcept C2781012912 @default.
• W2119413295 hasConcept C55493867 @default.
• W2119413295 hasConcept C61174792 @default.
• W2119413295 hasConcept C67018056 @default.
• W2119413295 hasConcept C86803240 @default.
• W2119413295 hasConcept C95444343 @default.
• W2119413295 hasConceptScore W2119413295C169760540 @default.
• W2119413295 hasConceptScore W2119413295C170493617 @default.
• W2119413295 hasConceptScore W2119413295C185592680 @default.
• W2119413295 hasConceptScore W2119413295C2777093970 @default.
• W2119413295 hasConceptScore W2119413295C2777624874 @default.
• W2119413295 hasConceptScore W2119413295C2779484449 @default.
• W2119413295 hasConceptScore W2119413295C2780827179 @default.
• W2119413295 hasConceptScore W2119413295C2781012912 @default.

• next