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• W2119451435 abstract "Human immunodeficiency virus Rev facilitates the cytoplasmic accumulation of viral RNAs that contain a Rev binding site. A human Rev-interacting protein (hRIP) was originally identified based on its ability to interact with the Rev nuclear export signal (NES) in yeast two-hybrid assays. To date, however, the function of hRIP and a role for hRIP in Rev-directed RNA export have remained elusive. Here we ablate hRIP activity with a dominant-negative mutant or RNA interference and analyze Rev function by RNA in situ hybridization. We find, unexpectedly, that in the absence of functional hRIP, Rev-directed RNAs mislocalize and aberrantly accumulate at the nuclear periphery, where hRIP is localized. In contrast, in the absence of Rev or the Rev cofactor CRM1, Rev-directed RNAs remain nuclear. We further show that the RNA mislocalization pattern resulting from loss of hRIP activity is highly specific to Rev function: the intracellular distribution of cellular poly(A) + mRNA, nuclear proteins, and, most important, NES-containing proteins, are unaffected. Thus, hRIP is an essential cellular Rev cofactor, which acts at a previously unanticipated step in HIV-1 RNA export: movement of RNAs from the nuclear periphery to the cytoplasm." @default.
• W2119451435 created "2016-06-24" @default.
• W2119451435 creator A5015893837 @default.
• W2119451435 creator A5067483520 @default.
• W2119451435 creator A5081542513 @default.
• W2119451435 creator A5084693345 @default.
• W2119451435 date "2003-12-30" @default.
• W2119451435 modified "2023-09-30" @default.
• W2119451435 title "hRIP, a cellular cofactor for Rev function, promotes release of HIV RNAs from the perinuclear region" @default.
• W2119451435 cites W13631346 @default.
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• W2119451435 cites W1491787713 @default.
• W2119451435 cites W1508323061 @default.
• W2119451435 cites W1546652468 @default.
• W2119451435 cites W1563529848 @default.
• W2119451435 cites W1566430503 @default.
• W2119451435 cites W1611419331 @default.
• W2119451435 cites W1681103111 @default.
• W2119451435 cites W1964400951 @default.
• W2119451435 cites W1964916693 @default.
• W2119451435 cites W1965448789 @default.
• W2119451435 cites W1968339979 @default.
• W2119451435 cites W1971531897 @default.
• W2119451435 cites W1972865566 @default.
• W2119451435 cites W1975631260 @default.
• W2119451435 cites W1976324670 @default.
• W2119451435 cites W1976579206 @default.
• W2119451435 cites W1977013948 @default.
• W2119451435 cites W1980255102 @default.
• W2119451435 cites W1982526666 @default.
• W2119451435 cites W1985288736 @default.
• W2119451435 cites W1986571649 @default.
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• W2119451435 cites W1990695832 @default.
• W2119451435 cites W1991548997 @default.
• W2119451435 cites W2003498148 @default.
• W2119451435 cites W2005927886 @default.
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• W2119451435 cites W2045186821 @default.
• W2119451435 cites W2048397315 @default.
• W2119451435 cites W2049277771 @default.
• W2119451435 cites W2055039476 @default.
• W2119451435 cites W2061120310 @default.
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• W2119451435 doi "https://doi.org/10.1101/gad.1149704" @default.
• W2119451435 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/314270" @default.
• W2119451435 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/14701878" @default.
• W2119451435 hasPublicationYear "2003" @default.
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