Matches in SemOpenAlex for { <https://semopenalex.org/work/W2119467662> ?p ?o ?g. }
- W2119467662 endingPage "220" @default.
- W2119467662 startingPage "201" @default.
- W2119467662 abstract "Method: We injected two drugs that modify the epigenome, the DNA methyltransferase inhibitor 5-aza-2´-deoxycytidine (5-aza-dC) and the histone deacetylase inhibitor trichostatin A (TSA), alone or in combination, into C57Bl/6 mice subjected to amputation through the mid-second phalanx of the third digit. Wound-site tissue was collected. Results: We observed increased staining of the stem cell markers Rex1 (Zfp42) and stem cell antigen-1 at digit amputation sites from drug-treated mice. Samples from 5-aza-dC plus TSA and TSA treated mice also showed increased proliferating cell nuclear antigen staining, a measure of cell proliferation. Drug treatments increased Msx1, but not Cyp26a1 or ALDH1a2 (RALDH2) mRNA. Conclusion: 5-aza-dC and TSA treatments stimulated cell proliferation at the amputation site, possibly via increased expression of genes involved in digit development and regeneration." @default.
- W2119467662 created "2016-06-24" @default.
- W2119467662 creator A5027498069 @default.
- W2119467662 creator A5030921116 @default.
- W2119467662 creator A5055444971 @default.
- W2119467662 creator A5069636370 @default.
- W2119467662 creator A5073097748 @default.
- W2119467662 date "2010-03-01" @default.
- W2119467662 modified "2023-10-13" @default.
- W2119467662 title "The effects of DNA methyltransferase inhibitors and histone deacetylase inhibitors on digit regeneration in mice" @default.
- W2119467662 cites W1560371023 @default.
- W2119467662 cites W1653639829 @default.
- W2119467662 cites W1767456499 @default.
- W2119467662 cites W1831897558 @default.
- W2119467662 cites W1868176480 @default.
- W2119467662 cites W1970097521 @default.
- W2119467662 cites W1972609799 @default.
- W2119467662 cites W1976967609 @default.
- W2119467662 cites W1978961048 @default.
- W2119467662 cites W1984495434 @default.
- W2119467662 cites W1986228299 @default.
- W2119467662 cites W1986905781 @default.
- W2119467662 cites W1993226419 @default.
- W2119467662 cites W1997048827 @default.
- W2119467662 cites W1998970920 @default.
- W2119467662 cites W2001642371 @default.
- W2119467662 cites W2003742149 @default.
- W2119467662 cites W2006557479 @default.
- W2119467662 cites W2009861852 @default.
- W2119467662 cites W2011660168 @default.
- W2119467662 cites W2012959105 @default.
- W2119467662 cites W2016392505 @default.
- W2119467662 cites W2024174149 @default.
- W2119467662 cites W2025909669 @default.
- W2119467662 cites W2030098953 @default.
- W2119467662 cites W2030780470 @default.
- W2119467662 cites W2036297157 @default.
- W2119467662 cites W2036820557 @default.
- W2119467662 cites W2038439057 @default.
- W2119467662 cites W2044670492 @default.
- W2119467662 cites W2044874551 @default.
- W2119467662 cites W2046050732 @default.
- W2119467662 cites W2046507480 @default.
- W2119467662 cites W2047015004 @default.
- W2119467662 cites W2049327036 @default.
- W2119467662 cites W2053683897 @default.
- W2119467662 cites W2054651337 @default.
- W2119467662 cites W2057151805 @default.
- W2119467662 cites W2057921641 @default.
- W2119467662 cites W2059984300 @default.
- W2119467662 cites W2060119002 @default.
- W2119467662 cites W2062278718 @default.
- W2119467662 cites W2064825670 @default.
- W2119467662 cites W2067056216 @default.
- W2119467662 cites W2069023992 @default.
- W2119467662 cites W2071853996 @default.
- W2119467662 cites W2073299273 @default.
- W2119467662 cites W2079130098 @default.
- W2119467662 cites W2085293124 @default.
- W2119467662 cites W2086990980 @default.
- W2119467662 cites W2087390112 @default.
- W2119467662 cites W2088553641 @default.
- W2119467662 cites W2090800257 @default.
- W2119467662 cites W2091260939 @default.
- W2119467662 cites W2092415112 @default.
- W2119467662 cites W2094836768 @default.
- W2119467662 cites W2096771882 @default.
- W2119467662 cites W2096903993 @default.
- W2119467662 cites W2108075096 @default.
- W2119467662 cites W2108838725 @default.
- W2119467662 cites W2110000041 @default.
- W2119467662 cites W2113074426 @default.
- W2119467662 cites W2115256283 @default.
- W2119467662 cites W2121367410 @default.
- W2119467662 cites W2122059700 @default.
- W2119467662 cites W2130239724 @default.
- W2119467662 cites W2139477237 @default.
- W2119467662 cites W2139670264 @default.
- W2119467662 cites W2141310245 @default.
- W2119467662 cites W2142648383 @default.
- W2119467662 cites W2147307409 @default.
- W2119467662 cites W2150761291 @default.
- W2119467662 cites W2153335014 @default.
- W2119467662 cites W2154712506 @default.
- W2119467662 cites W2155265491 @default.
- W2119467662 cites W2158048826 @default.
- W2119467662 cites W2163583950 @default.
- W2119467662 cites W2164012688 @default.
- W2119467662 cites W2173497140 @default.
- W2119467662 cites W2184007568 @default.
- W2119467662 cites W2189430740 @default.
- W2119467662 cites W34668368 @default.
- W2119467662 cites W4295836001 @default.
- W2119467662 doi "https://doi.org/10.2217/rme.09.91" @default.
- W2119467662 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/20210581" @default.
- W2119467662 hasPublicationYear "2010" @default.
- W2119467662 type Work @default.
- W2119467662 sameAs 2119467662 @default.