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• W2119495153 abstract "The mouse mutant curly-tail is an animal model for human neural tube defects (NTD). Around 60% spontaneously have NTD. It has been found that maternal administration of hydroxyurea, mitomycin C, or 5-fluorouracil on day 9 of pregnancy, that is, when the fetal neural tube is in the final stages of closure, leads to a significant reduction in the proportion of NTD (to 15 to 20%) in the offspring, while total litter size is unaffected. All these substances are inhibitors of DNA synthesis, yet are apparently beneficial to subjects predisposed to NTD. As a consequence, it is suggested that the underlying mechanism causing NTD in the mice, and also in man, is a basic metabolic defect in DNA synthesis which affects cell replication and results in abnormal morphogenesis of the neuraxis." @default.
• W2119495153 created "2016-06-24" @default.
• W2119495153 creator A5086049639 @default.
• W2119495153 date "1983-06-01" @default.
• W2119495153 modified "2023-10-14" @default.
• W2119495153 title "The cause of neural tube defects: some experiments and a hypothesis." @default.
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• W2119495153 doi "https://doi.org/10.1136/jmg.20.3.164" @default.
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