FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2119500208> ?p ?o ?g. }

• W2119500208 endingPage "7568" @default.
• W2119500208 startingPage "7568" @default.
• W2119500208 abstract "Ulcerative colitis (UC) and Crohn's disease (CD) are the major forms of idiopathic inflammatory bowel disease (IBD). Both UC and CD are debilitating chronic disorders that afflict millions of individuals throughout the world with symptoms which impair function and quality of life. The etiology of IBD is inadequately understood and therefore, drug therapy has been empirical instead of being based on sound understanding of IBD pathogenesis. This is a major factor for poor drug efficacy and drug related side effects that often add to the disease complexity. The development of biologicals notably infliximab to intercept tumor necrosis factor (TNF)-alpha reflects some progress, albeit major concern about their side effects and lack of long-term safety and efficacy profiles. However, IBD seems to be perpetuated by inflammatory cytokines like TNF-alpha, interleukin (IL)-1beta, IL-6 and IL-8 for which activated peripheral granulocytes and monocytes/macrophages (GM) are major sources. Further, in IBD, peripheral GMs are elevated with activation behavior, increased survival time and are found in vast numbers within the inflamed intestinal mucosa; they are suspected to be major factors in the immunopathogenesis of IBD. Hence, peripheral blood GMs should be appropriate targets of therapy. The Adacolumn is a medical device developed for selective depletion of GM by receptor-mediated adsorption (GMA). Clinical data show GMA, in patients with steroid dependent or steroid refractory UC, is associated with up to 85% efficacy and tapering or discontinuation of steroids, while in steroid naive patients (the best responders), GMA spares patients from exposure to steroids. Likewise, GMA at appropriate intervals in patients at a high risk of clinical relapse suppresses relapse thus sparing the patients from the morbidity associated with IBD relapse. Further, GMA appears to reduce the number of patients being submitted to colectomy or exposure to unsafe immunosupressants. First UC episode, steroid naivety and short disease duration appear good predictors of response to GMA and based on the available data, GMA seems to have an excellent safety profile." @default.
• W2119500208 created "2016-06-24" @default.
• W2119500208 creator A5062910921 @default.
• W2119500208 date "2006-01-01" @default.
• W2119500208 modified "2023-10-18" @default.
• W2119500208 title "Positions of selective leukocytapheresis in the medical therapy of ulcerative colitis" @default.
• W2119500208 cites W1501069386 @default.
• W2119500208 cites W1513433299 @default.
• W2119500208 cites W1539312716 @default.
• W2119500208 cites W155529673 @default.
• W2119500208 cites W1593679868 @default.
• W2119500208 cites W1600501096 @default.
• W2119500208 cites W1628031477 @default.
• W2119500208 cites W1964593079 @default.
• W2119500208 cites W1967970880 @default.
• W2119500208 cites W1969511625 @default.
• W2119500208 cites W1972640453 @default.
• W2119500208 cites W1977554333 @default.
• W2119500208 cites W1977926034 @default.
• W2119500208 cites W1980274986 @default.
• W2119500208 cites W1987064800 @default.
• W2119500208 cites W1987925515 @default.
• W2119500208 cites W1989347679 @default.
• W2119500208 cites W1989658278 @default.
• W2119500208 cites W1990909429 @default.
• W2119500208 cites W1991340166 @default.
• W2119500208 cites W1992650609 @default.
• W2119500208 cites W1996981713 @default.
• W2119500208 cites W1998577012 @default.
• W2119500208 cites W1998669743 @default.
• W2119500208 cites W2001674255 @default.
• W2119500208 cites W2003492229 @default.
• W2119500208 cites W2003888527 @default.
• W2119500208 cites W2008058202 @default.
• W2119500208 cites W2010753554 @default.
• W2119500208 cites W2012083687 @default.
• W2119500208 cites W2013829686 @default.
• W2119500208 cites W2017059356 @default.
• W2119500208 cites W2025207379 @default.
• W2119500208 cites W2027179536 @default.
• W2119500208 cites W2037060043 @default.
• W2119500208 cites W2041847139 @default.
• W2119500208 cites W2043530745 @default.
• W2119500208 cites W2049830622 @default.
• W2119500208 cites W2050011892 @default.
• W2119500208 cites W2052435488 @default.
• W2119500208 cites W2057264565 @default.
• W2119500208 cites W2057751431 @default.
• W2119500208 cites W2060081626 @default.
• W2119500208 cites W2061002171 @default.
• W2119500208 cites W2064305620 @default.
• W2119500208 cites W2064397952 @default.
• W2119500208 cites W2075836508 @default.
• W2119500208 cites W2080555804 @default.
• W2119500208 cites W2081100902 @default.
• W2119500208 cites W2081134502 @default.
• W2119500208 cites W2086203819 @default.
• W2119500208 cites W2087461697 @default.
• W2119500208 cites W2088770096 @default.
• W2119500208 cites W2093514179 @default.
• W2119500208 cites W2102973745 @default.
• W2119500208 cites W2111045741 @default.
• W2119500208 cites W2113990199 @default.
• W2119500208 cites W2123537724 @default.
• W2119500208 cites W2127281820 @default.
• W2119500208 cites W2129810681 @default.
• W2119500208 cites W2131882149 @default.
• W2119500208 cites W2140453226 @default.
• W2119500208 cites W2141083324 @default.
• W2119500208 cites W2143904760 @default.
• W2119500208 cites W2146906769 @default.
• W2119500208 cites W2153627052 @default.
• W2119500208 cites W2155438550 @default.
• W2119500208 cites W2156784778 @default.
• W2119500208 cites W2157279567 @default.
• W2119500208 cites W2157361915 @default.
• W2119500208 cites W2160889746 @default.
• W2119500208 cites W2165655699 @default.
• W2119500208 cites W2166930089 @default.
• W2119500208 cites W2171297959 @default.
• W2119500208 cites W2171341132 @default.
• W2119500208 cites W2171435013 @default.
• W2119500208 cites W229107160 @default.
• W2119500208 cites W2319895888 @default.
• W2119500208 cites W2321453230 @default.
• W2119500208 cites W2396365631 @default.
• W2119500208 cites W2397841334 @default.
• W2119500208 cites W2414234699 @default.
• W2119500208 cites W26342267 @default.
• W2119500208 cites W363863757 @default.
• W2119500208 cites W4237097915 @default.
• W2119500208 cites W4292198229 @default.
• W2119500208 doi "https://doi.org/10.3748/wjg.v12.i47.7568" @default.
• W2119500208 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4088036" @default.
• W2119500208 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/17171783" @default.
• W2119500208 hasPublicationYear "2006" @default.
• W2119500208 type Work @default.
• W2119500208 sameAs 2119500208 @default.

• next