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• W2119501325 abstract "Alterations in inflammatory process, neuronal death, and glia response have been observed under manipulation of interleukin-1 (IL-1) and subsequent signaling through the type 1 IL-1 receptor (IL-1R1). To investigate the influence of IL-1R1 activation in the pathophysiology of a chemical-induced injury to the murine hippocampus, we examined the level and pattern of neuronal death and neuroinflammation in male weanling mice exposed to trimethyltin hydroxide (2.0 mg TMT/kg, i.p.). Dentate granule cell death occurred at 6 h post-TMT as detected by active caspase 3 immunostaining and presence of lectin positive microglia. The severity of neuronal death and microglia response increased by 12-24 h with elevations in mRNA levels for TNFalpha and IL-1alpha. In IL-1R1 null (IL-1R1-/-) mice, the pattern and severity of neuronal death at 24 or 72 h post-TMT was similar as compared to wildtype (WT) mice. In both groups, mRNA levels for TNFalpha and MIP-1alpha were elevated, no significant change was seen in either IL-1alpha or IL-1beta, and the early activation of microglia, including their ability to progress to a phagocytic phenotype, was maintained. Compared to WT mice, IL-1R1-/- mice displayed a limited glial fibrillary acidic protein (GFAP) astrocytic response, as well as a preferential induction in mRNA levels of Fas signaling components. Cumulatively, these results indicate that IL-1R1 activation is not necessary for TMT-induced death of dentate granule neurons or local activation of microglia; however, IL-1R1 signaling is involved in mediating the structural response of astrocytes to injury and may regulate apoptotic mechanisms via Fas signaling components." @default.
• W2119501325 created "2016-06-24" @default.
• W2119501325 creator A5043170116 @default.
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• W2119501325 creator A5079258467 @default.
• W2119501325 creator A5082359670 @default.
• W2119501325 creator A5088686533 @default.
• W2119501325 date "2008-02-01" @default.
• W2119501325 modified "2023-10-16" @default.
• W2119501325 title "The type 1 interleukin 1 receptor is not required for the death of murine hippocampal dentate granule cells and microglia activation" @default.
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• W2119501325 doi "https://doi.org/10.1016/j.brainres.2007.11.076" @default.
• W2119501325 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2274920" @default.
• W2119501325 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/18191113" @default.
• W2119501325 hasPublicationYear "2008" @default.
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