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• W2119514257 abstract "Tocotrienols, members of the vitamin E family, are natural compounds found in a number of vegetable oils, wheat germ, barley, and certain types of nuts and grains. Like tocopherols, tocotrienols are also of four types viz. alpha, beta, gamma and delta. Unlike tocopherols, tocotrienols are unsaturated and possess an isoprenoid side chain. Tocopherols are lipophilic in nature and are found in association with lipoproteins, fat deposits and cellular membranes and protect the polyunsaturated fatty acids from peroxidation reactions. The unsaturated chain of tocotrienol allows an efficient penetration into tissues that have saturated fatty layers such as the brain and liver. Recent mechanistic studies indicate that other forms of vitamin E, such as γ-tocopherol, δ-tocopherol, and γ-tocotrienol, have unique antioxidant and anti-inflammatory properties that are superior to those of α-tocopherol against chronic diseases. These forms scavenge reactive nitrogen species, inhibit cyclooxygenase- and 5-lipoxygenase-catalyzed eicosanoids and suppress proinflammatory signalling, such as NF-κB and STAT. The animal and human studies show tocotrienols may be useful against inflammation-associated diseases. Many of the functions of tocotrienols are related to its antioxidant properties and its varied effects are due to it behaving as a signalling molecule. Tocotrienols exhibit biological activities that are also exhibited by tocopherols, such as neuroprotective, anti-cancer, anti-inflammatory and cholesterol lowering properties. Hence, effort has been made to compile the different functions and properties of tocotrienols in experimental model systems and humans. This article constitutes an in-depth review of the pharmacology, metabolism, toxicology and biosafety aspects of tocotrienols. Tocotrienols are detectable at appreciable levels in the plasma after supplementations. However, there is inadequate data on the plasma concentrations of tocotrienols that are sufficient to demonstrate significant physiological effect and biodistribution studies show their accumulation in vital organs of the body. Considering the wide range of benefits that tocotrienols possesses against some common human ailments and having a promising potential, the experimental analysis accounts for about a small fraction of all vitamin E research. The current state of knowledge deserves further investigation into this lesser known form of vitamin E." @default.
• W2119514257 created "2016-06-24" @default.
• W2119514257 creator A5011246605 @default.
• W2119514257 creator A5035333297 @default.
• W2119514257 creator A5042446340 @default.
• W2119514257 creator A5065099206 @default.
• W2119514257 date "2014-11-12" @default.
• W2119514257 modified "2023-10-11" @default.
• W2119514257 title "Pharmacological potential of tocotrienols: a review" @default.
• W2119514257 cites W10495483 @default.
• W2119514257 cites W113575783 @default.
• W2119514257 cites W1535472961 @default.
• W2119514257 cites W1541711964 @default.
• W2119514257 cites W1559597940 @default.
• W2119514257 cites W1565499480 @default.
• W2119514257 cites W1565959930 @default.
• W2119514257 cites W1577666478 @default.
• W2119514257 cites W1587007485 @default.
• W2119514257 cites W1612952173 @default.
• W2119514257 cites W1678920698 @default.
• W2119514257 cites W1763666518 @default.
• W2119514257 cites W1765361683 @default.
• W2119514257 cites W1782490506 @default.
• W2119514257 cites W1824614065 @default.
• W2119514257 cites W1835622051 @default.
• W2119514257 cites W1859647582 @default.
• W2119514257 cites W1865284955 @default.
• W2119514257 cites W1880335557 @default.
• W2119514257 cites W1905706123 @default.
• W2119514257 cites W1920904246 @default.
• W2119514257 cites W1935855454 @default.
• W2119514257 cites W1941294128 @default.
• W2119514257 cites W1963682394 @default.
• W2119514257 cites W1964537939 @default.
• W2119514257 cites W1964867222 @default.
• W2119514257 cites W1965009189 @default.
• W2119514257 cites W1965158780 @default.
• W2119514257 cites W1965809953 @default.
• W2119514257 cites W1966215425 @default.
• W2119514257 cites W1967513458 @default.
• W2119514257 cites W1968076621 @default.
• W2119514257 cites W1968405804 @default.
• W2119514257 cites W1968699748 @default.
• W2119514257 cites W1971618316 @default.
• W2119514257 cites W1974127432 @default.
• W2119514257 cites W1974408096 @default.
• W2119514257 cites W1974992441 @default.
• W2119514257 cites W1975967573 @default.
• W2119514257 cites W1976450853 @default.
• W2119514257 cites W1980599464 @default.
• W2119514257 cites W1981013304 @default.
• W2119514257 cites W1982346714 @default.
• W2119514257 cites W1983042517 @default.
• W2119514257 cites W1983324850 @default.
• W2119514257 cites W1986323030 @default.
• W2119514257 cites W1989604654 @default.
• W2119514257 cites W1989900621 @default.
• W2119514257 cites W1990462052 @default.
• W2119514257 cites W1990803139 @default.
• W2119514257 cites W1991224714 @default.
• W2119514257 cites W1991665174 @default.
• W2119514257 cites W1992334757 @default.
• W2119514257 cites W1994064108 @default.
• W2119514257 cites W1995246301 @default.
• W2119514257 cites W1997432357 @default.
• W2119514257 cites W1998120765 @default.
• W2119514257 cites W2001261909 @default.
• W2119514257 cites W2002378340 @default.
• W2119514257 cites W2003508482 @default.
• W2119514257 cites W2004651934 @default.
• W2119514257 cites W2004808149 @default.
• W2119514257 cites W2005877555 @default.
• W2119514257 cites W2006919791 @default.
• W2119514257 cites W2008664751 @default.
• W2119514257 cites W2008836533 @default.
• W2119514257 cites W2009655951 @default.
• W2119514257 cites W2011522235 @default.
• W2119514257 cites W2012795254 @default.
• W2119514257 cites W2012810997 @default.
• W2119514257 cites W2013837833 @default.
• W2119514257 cites W2014443826 @default.
• W2119514257 cites W2015187968 @default.
• W2119514257 cites W2015319106 @default.
• W2119514257 cites W2016000854 @default.
• W2119514257 cites W2017729853 @default.
• W2119514257 cites W2017802456 @default.
• W2119514257 cites W2020493351 @default.
• W2119514257 cites W2020861040 @default.
• W2119514257 cites W2020994403 @default.
• W2119514257 cites W2023403894 @default.
• W2119514257 cites W2024768816 @default.
• W2119514257 cites W2026037353 @default.
• W2119514257 cites W2026403788 @default.
• W2119514257 cites W2026482598 @default.
• W2119514257 cites W2029906657 @default.
• W2119514257 cites W2030094288 @default.
• W2119514257 cites W2030140331 @default.
• W2119514257 cites W2034374426 @default.
• W2119514257 cites W2034895966 @default.
• W2119514257 cites W2035261223 @default.

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